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DNA double-strand breaks activate a multi-functional genetic program in developing lymphocytes.

Bredemeyer AL, Helmink BA, Innes CL, Calderon B, McGinnis LM, Mahowald GK, Gapud EJ, Walker LM, Collins JB, Weaver BK, Mandik-Nayak L, Schreiber RD, Allen PM, May MJ, Paules RS, Bassing CH, Sleckman BP.

Nature. 2008 Dec 11;456(7223):819-23. doi: 10.1038/nature07392. Epub 2008 Oct 12.


Integrated signaling in developing lymphocytes: the role of DNA damage responses.

Bednarski JJ, Sleckman BP.

Cell Cycle. 2012 Nov 15;11(22):4129-34. doi: 10.4161/cc.22021. Epub 2012 Oct 3.


DNA damage activates a complex transcriptional response in murine lymphocytes that includes both physiological and cancer-predisposition programs.

Innes CL, Hesse JE, Palii SS, Helmink BA, Holub AJ, Sleckman BP, Paules RS.

BMC Genomics. 2013 Mar 12;14:163. doi: 10.1186/1471-2164-14-163.


Aberrantly resolved RAG-mediated DNA breaks in Atm-deficient lymphocytes target chromosomal breakpoints in cis.

Mahowald GK, Baron JM, Mahowald MA, Kulkarni S, Bredemeyer AL, Bassing CH, Sleckman BP.

Proc Natl Acad Sci U S A. 2009 Oct 27;106(43):18339-44. doi: 10.1073/pnas.0902545106. Epub 2009 Oct 9.


MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks.

Helmink BA, Bredemeyer AL, Lee BS, Huang CY, Sharma GG, Walker LM, Bednarski JJ, Lee WL, Pandita TK, Bassing CH, Sleckman BP.

J Exp Med. 2009 Mar 16;206(3):669-79. doi: 10.1084/jem.20081326. Epub 2009 Feb 16.


RAG-mediated DNA double-strand breaks activate a cell type-specific checkpoint to inhibit pre-B cell receptor signals.

Bednarski JJ, Pandey R, Schulte E, White LS, Chen BR, Sandoval GJ, Kohyama M, Haldar M, Nickless A, Trott A, Cheng G, Murphy KM, Bassing CH, Payton JE, Sleckman BP.

J Exp Med. 2016 Feb 8;213(2):209-23. doi: 10.1084/jem.20151048. Epub 2016 Feb 1.


ATM and p53 are essential in the cell-cycle containment of DNA breaks during V(D)J recombination in vivo.

Dujka ME, Puebla-Osorio N, Tavana O, Sang M, Zhu C.

Oncogene. 2010 Feb 18;29(7):957-65. doi: 10.1038/onc.2009.394. Epub 2009 Nov 16.


Aberrant V(D)J recombination in ataxia telangiectasia mutated-deficient lymphocytes is dependent on nonhomologous DNA end joining.

Bredemeyer AL, Huang CY, Walker LM, Bassing CH, Sleckman BP.

J Immunol. 2008 Aug 15;181(4):2620-5.


B-cell differentiation stimulated by physiologic DNA double strand breaks.

Walsh NC, Teitell M.

Cell Cycle. 2011 Jan 15;10(2):176-7. Epub 2011 Jan 15. No abstract available.


AID-induced genotoxic stress promotes B cell differentiation in the germinal center via ATM and LKB1 signaling.

Sherman MH, Kuraishy AI, Deshpande C, Hong JS, Cacalano NA, Gatti RA, Manis JP, Damore MA, Pellegrini M, Teitell MA.

Mol Cell. 2010 Sep 24;39(6):873-85. doi: 10.1016/j.molcel.2010.08.019.


Rapid activation of ATM on DNA flanking double-strand breaks.

You Z, Bailis JM, Johnson SA, Dilworth SM, Hunter T.

Nat Cell Biol. 2007 Nov;9(11):1311-8. Epub 2007 Oct 21.


The ataxia telangiectasia mutated kinase controls Igκ allelic exclusion by inhibiting secondary Vκ-to-Jκ rearrangements.

Steinel NC, Lee BS, Tubbs AT, Bednarski JJ, Schulte E, Yang-Iott KS, Schatz DG, Sleckman BP, Bassing CH.

J Exp Med. 2013 Feb 11;210(2):233-9. doi: 10.1084/jem.20121605. Epub 2013 Feb 4.


ATM stabilizes DNA double-strand-break complexes during V(D)J recombination.

Bredemeyer AL, Sharma GG, Huang CY, Helmink BA, Walker LM, Khor KC, Nuskey B, Sullivan KE, Pandita TK, Bassing CH, Sleckman BP.

Nature. 2006 Jul 27;442(7101):466-70. Epub 2006 Jun 14.


Repair of chromosomal RAG-mediated DNA breaks by mutant RAG proteins lacking phosphatidylinositol 3-like kinase consensus phosphorylation sites.

Gapud EJ, Lee BS, Mahowald GK, Bassing CH, Sleckman BP.

J Immunol. 2011 Aug 15;187(4):1826-34. doi: 10.4049/jimmunol.1101388. Epub 2011 Jul 8.


H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes.

Helmink BA, Tubbs AT, Dorsett Y, Bednarski JJ, Walker LM, Feng Z, Sharma GG, McKinnon PJ, Zhang J, Bassing CH, Sleckman BP.

Nature. 2011 Jan 13;469(7329):245-9. doi: 10.1038/nature09585. Epub 2010 Dec 15. Erratum in: Nature. 2011 Apr 14;472(7342):247.


Artemis-independent functions of DNA-dependent protein kinase in Ig heavy chain class switch recombination and development.

Rooney S, Alt FW, Sekiguchi J, Manis JP.

Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2471-5. Epub 2005 Feb 7.


Pharmacological inhibition of ATM by KU55933 stimulates ATM transcription.

Khalil HS, Tummala H, Hupp TR, Zhelev N.

Exp Biol Med (Maywood). 2012 Jun;237(6):622-34. doi: 10.1258/ebm.2012.011378. Epub 2012 Jun 22.


Persistence of unrepaired DNA double strand breaks caused by inhibition of ATM does not lead to radio-sensitisation in the absence of NF-κB activation.

Veuger SJ, Durkacz BW.

DNA Repair (Amst). 2011 Feb 7;10(2):235-44. doi: 10.1016/j.dnarep.2010.11.005. Epub 2010 Dec 8.


Regulation of reactive oxygen species by Atm is essential for proper response to DNA double-strand breaks in lymphocytes.

Ito K, Takubo K, Arai F, Satoh H, Matsuoka S, Ohmura M, Naka K, Azuma M, Miyamoto K, Hosokawa K, Ikeda Y, Mak TW, Suda T, Hirao A.

J Immunol. 2007 Jan 1;178(1):103-10.


ATM deficiency impairs thymocyte maturation because of defective resolution of T cell receptor alpha locus coding end breaks.

Vacchio MS, Olaru A, Livak F, Hodes RJ.

Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6323-8. Epub 2007 Apr 3.

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