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Items: 1 to 20 of 143


Lrp4 is a receptor for Agrin and forms a complex with MuSK.

Kim N, Stiegler AL, Cameron TO, Hallock PT, Gomez AM, Huang JH, Hubbard SR, Dustin ML, Burden SJ.

Cell. 2008 Oct 17;135(2):334-42. doi: 10.1016/j.cell.2008.10.002. Epub 2008 Oct 9.


The MuSK activator agrin has a separate role essential for postnatal maintenance of neuromuscular synapses.

Tezuka T, Inoue A, Hoshi T, Weatherbee SD, Burgess RW, Ueta R, Yamanashi Y.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16556-61. doi: 10.1073/pnas.1408409111. Epub 2014 Nov 3.


LRP4 serves as a coreceptor of agrin.

Zhang B, Luo S, Wang Q, Suzuki T, Xiong WC, Mei L.

Neuron. 2008 Oct 23;60(2):285-97. doi: 10.1016/j.neuron.2008.10.006.


Agrin binds to the N-terminal region of Lrp4 protein and stimulates association between Lrp4 and the first immunoglobulin-like domain in muscle-specific kinase (MuSK).

Zhang W, Coldefy AS, Hubbard SR, Burden SJ.

J Biol Chem. 2011 Nov 25;286(47):40624-30. doi: 10.1074/jbc.M111.279307. Epub 2011 Oct 3.


LRP4 third β-propeller domain mutations cause novel congenital myasthenia by compromising agrin-mediated MuSK signaling in a position-specific manner.

Ohkawara B, Cabrera-Serrano M, Nakata T, Milone M, Asai N, Ito K, Ito M, Masuda A, Ito Y, Engel AG, Ohno K.

Hum Mol Genet. 2014 Apr 1;23(7):1856-68. doi: 10.1093/hmg/ddt578. Epub 2013 Nov 13.


Lrp4 is a retrograde signal for presynaptic differentiation at neuromuscular synapses.

Yumoto N, Kim N, Burden SJ.

Nature. 2012 Sep 20;489(7416):438-42. doi: 10.1038/nature11348. Epub 2012 Aug 1.


The extracellular region of Lrp4 is sufficient to mediate neuromuscular synapse formation.

Gomez AM, Burden SJ.

Dev Dyn. 2011 Dec;240(12):2626-33. doi: 10.1002/dvdy.22772. Epub 2011 Oct 28.


Structural basis of agrin-LRP4-MuSK signaling.

Zong Y, Zhang B, Gu S, Lee K, Zhou J, Yao G, Figueiredo D, Perry K, Mei L, Jin R.

Genes Dev. 2012 Feb 1;26(3):247-58. doi: 10.1101/gad.180885.111.


Structure and activation of MuSK, a receptor tyrosine kinase central to neuromuscular junction formation.

Hubbard SR, Gnanasambandan K.

Biochim Biophys Acta. 2013 Oct;1834(10):2166-9. doi: 10.1016/j.bbapap.2013.02.034. Epub 2013 Mar 5. Review.


New dogs in the dogma: Lrp4 and Tid1 in neuromuscular synapse formation.

Song Y, Balice-Gordon R.

Neuron. 2008 Nov 26;60(4):526-8. doi: 10.1016/j.neuron.2008.11.003. Review.


Mutations in MUSK causing congenital myasthenic syndrome impair MuSK-Dok-7 interaction.

Maselli RA, Arredondo J, Cagney O, Ng JJ, Anderson JA, Williams C, Gerke BJ, Soliven B, Wollmann RL.

Hum Mol Genet. 2010 Jun 15;19(12):2370-9. doi: 10.1093/hmg/ddq110. Epub 2010 Apr 6.


APP interacts with LRP4 and agrin to coordinate the development of the neuromuscular junction in mice.

Choi HY, Liu Y, Tennert C, Sugiura Y, Karakatsani A, Kröger S, Johnson EB, Hammer RE, Lin W, Herz J.

Elife. 2013 Aug 20;2:e00220. doi: 10.7554/eLife.00220.


Differential regulation of AChR clustering in the polar and equatorial region of murine muscle spindles.

Zhang Y, Lin S, Karakatsani A, Rüegg MA, Kröger S.

Eur J Neurosci. 2015 Jan;41(1):69-78. doi: 10.1111/ejn.12768. Epub 2014 Nov 6.


Dok-7 regulates neuromuscular synapse formation by recruiting Crk and Crk-L.

Hallock PT, Xu CF, Park TJ, Neubert TA, Curran T, Burden SJ.

Genes Dev. 2010 Nov 1;24(21):2451-61. doi: 10.1101/gad.1977710.


Collagen Q and anti-MuSK autoantibody competitively suppress agrin/LRP4/MuSK signaling.

Otsuka K, Ito M, Ohkawara B, Masuda A, Kawakami Y, Sahashi K, Nishida H, Mabuchi N, Takano A, Engel AG, Ohno K.

Sci Rep. 2015 Sep 10;5:13928. doi: 10.1038/srep13928.


The role of MuSK in synapse formation and neuromuscular disease.

Burden SJ, Yumoto N, Zhang W.

Cold Spring Harb Perspect Biol. 2013 May 1;5(5):a009167. doi: 10.1101/cshperspect.a009167. Review.


Mesdc2 plays a key role in cell-surface expression of Lrp4 and postsynaptic specialization in myotubes.

Hoshi T, Tezuka T, Yokoyama K, Iemura S, Natsume T, Yamanashi Y.

FEBS Lett. 2013 Nov 29;587(23):3749-54. doi: 10.1016/j.febslet.2013.10.001. Epub 2013 Oct 15.


A novel pathway for MuSK to induce key genes in neuromuscular synapse formation.

Lacazette E, Le Calvez S, Gajendran N, Brenner HR.

J Cell Biol. 2003 May 26;161(4):727-36. Epub 2003 May 19.


Developmental consequences of the ColQ/MuSK interactions.

Karmouch J, Dobbertin A, Sigoillot S, Legay C.

Chem Biol Interact. 2013 Mar 25;203(1):287-91. doi: 10.1016/j.cbi.2012.10.006. Epub 2012 Oct 23. Review.


Postsynaptic requirement for Abl kinases in assembly of the neuromuscular junction.

Finn AJ, Feng G, Pendergast AM.

Nat Neurosci. 2003 Jul;6(7):717-23.


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