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RAG2-/- gamma(c)-/- mice transplanted with CD34+ cells from human cord blood show low levels of intestinal engraftment and are resistant to rectal transmission of human immunodeficiency virus.

Hofer U, Baenziger S, Heikenwalder M, Schlaepfer E, Gehre N, Regenass S, Brunner T, Speck RF.

J Virol. 2008 Dec;82(24):12145-53. doi: 10.1128/JVI.01105-08. Epub 2008 Oct 8.


Mucosal transmission of R5 and X4 tropic HIV-1 via vaginal and rectal routes in humanized Rag2-/- gammac -/- (RAG-hu) mice.

Berges BK, Akkina SR, Folkvord JM, Connick E, Akkina R.

Virology. 2008 Apr 10;373(2):342-51. doi: 10.1016/j.virol.2007.11.020. Epub 2008 Jan 18.


Disseminated and sustained HIV infection in CD34+ cord blood cell-transplanted Rag2-/-gamma c-/- mice.

Baenziger S, Tussiwand R, Schlaepfer E, Mazzucchelli L, Heikenwalder M, Kurrer MO, Behnke S, Frey J, Oxenius A, Joller H, Aguzzi A, Manz MG, Speck RF.

Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15951-6. Epub 2006 Oct 12.


Human immunodeficiency virus type 1 pathobiology studied in humanized BALB/c-Rag2-/-gammac-/- mice.

Gorantla S, Sneller H, Walters L, Sharp JG, Pirruccello SJ, West JT, Wood C, Dewhurst S, Gendelman HE, Poluektova L.

J Virol. 2007 Mar;81(6):2700-12. Epub 2006 Dec 20.


Reconstitution of human lymphocytes following ex vivo expansion of human umbilical cord blood CD34+ cells and transplantation in Rag2-/- gamma c-/- mice model.

Choi BK, Joo SY, Moon C, Park KS, Kim SH, Park JB, Jung GO, Choi GS, Kwon CH, Chun JM, Joh JW, Lee SK, Kim SJ.

Transplant Proc. 2008 Oct;40(8):2655-60. doi: 10.1016/j.transproceed.2008.08.011.


An improved protocol for efficient engraftment in NOD/LTSZ-SCIDIL-2Rγnull mice allows HIV replication and development of anti-HIV immune responses.

Singh M, Singh P, Gaudray G, Musumeci L, Thielen C, Vaira D, Vandergeeten C, Delacroix L, Van Gulck E, Vanham G, de Leval L, Rahmouni S, Moutschen M.

PLoS One. 2012;7(6):e38491. doi: 10.1371/journal.pone.0038491. Epub 2012 Jun 4.


CD34+ cord blood cell-transplanted Rag2-/- gamma(c)-/- mice as a model for Epstein-Barr virus infection.

Cocco M, Bellan C, Tussiwand R, Corti D, Traggiai E, Lazzi S, Mannucci S, Bronz L, Palummo N, Ginanneschi C, Tosi P, Lanzavecchia A, Manz MG, Leoncini L.

Am J Pathol. 2008 Nov;173(5):1369-78. doi: 10.2353/ajpath.2008.071186. Epub 2008 Oct 9.


Humanized Rag1-/- γc-/- mice support multilineage hematopoiesis and are susceptible to HIV-1 infection via systemic and vaginal routes.

Akkina R, Berges BK, Palmer BE, Remling L, Neff CP, Kuruvilla J, Connick E, Folkvord J, Gagliardi K, Kassu A, Akkina SR.

PLoS One. 2011;6(6):e20169. doi: 10.1371/journal.pone.0020169. Epub 2011 Jun 14.


Prevention of SIV rectal transmission and priming of T cell responses in macaques after local pre-exposure application of tenofovir gel.

Cranage M, Sharpe S, Herrera C, Cope A, Dennis M, Berry N, Ham C, Heeney J, Rezk N, Kashuba A, Anton P, McGowan I, Shattock R.

PLoS Med. 2008 Aug 5;5(8):e157; discussion e157. doi: 10.1371/journal.pmed.0050157.


HIV-1 infection and CD4 T cell depletion in the humanized Rag2-/-gamma c-/- (RAG-hu) mouse model.

Berges BK, Wheat WH, Palmer BE, Connick E, Akkina R.

Retrovirology. 2006 Nov 1;3:76.


FoxP3+CD4+ regulatory T cells play an important role in acute HIV-1 infection in humanized Rag2-/-gammaC-/- mice in vivo.

Jiang Q, Zhang L, Wang R, Jeffrey J, Washburn ML, Brouwer D, Barbour S, Kovalev GI, Unutmaz D, Su L.

Blood. 2008 Oct 1;112(7):2858-68. doi: 10.1182/blood-2008-03-145946. Epub 2008 Jun 10.


Development of human B cells and antibodies following human hematopoietic stem cell transplantation to Rag2(-/-)γc(-/-) mice.

Tanner A, Hallam SJ, Nielsen SJ, Cuadra GI, Berges BK.

Transpl Immunol. 2015 Jun;32(3):144-50. doi: 10.1016/j.trim.2015.03.002. Epub 2015 Apr 2.


Characterization of HIV-1 infection in the humanized Rag2-/-γc-/- mouse model.

Sanchez FM, Berges BK.

Methods Mol Biol. 2013;1031:215-22. doi: 10.1007/978-1-62703-481-4_24.


Intrarectal transmission, systemic infection, and CD4+ T cell depletion in humanized mice infected with HIV-1.

Sun Z, Denton PW, Estes JD, Othieno FA, Wei BL, Wege AK, Melkus MW, Padgett-Thomas A, Zupancic M, Haase AT, Garcia JV.

J Exp Med. 2007 Apr 16;204(4):705-14. Epub 2007 Mar 26.


Use of a novel chimeric mouse model with a functionally active human immune system to study human immunodeficiency virus type 1 infection.

An DS, Poon B, Ho Tsong Fang R, Weijer K, Blom B, Spits H, Chen IS, Uittenbogaart CH.

Clin Vaccine Immunol. 2007 Apr;14(4):391-6. Epub 2007 Feb 21.


Rectal transmission of human immunodeficiency virus type 1 to chimpanzees.

Fultz PN, Wei Q, Yue L.

J Infect Dis. 1999 May;179 Suppl 3:S418-21.


Humanized Rag2(-/-)gammac(-/-) (RAG-hu) mice can sustain long-term chronic HIV-1 infection lasting more than a year.

Berges BK, Akkina SR, Remling L, Akkina R.

Virology. 2010 Feb 5;397(1):100-3. doi: 10.1016/j.virol.2009.10.034. Epub 2009 Nov 18.


Development of functional human immune system with the transplantations of human fetal liver/thymus tissues and expanded hematopoietic stem cells in RAG2-/-gamma(c)-/- MICE.

Joo SY, Choi BK, Kang MJ, Jung DY, Park KS, Park JB, Choi GS, Joh J, Kwon CH, Jung GO, Lee SK, Kim SJ.

Transplant Proc. 2009 Jun;41(5):1885-90. doi: 10.1016/j.transproceed.2009.02.074.


Hematopoietic stem cell-engrafted NOD/SCID/IL2Rgamma null mice develop human lymphoid systems and induce long-lasting HIV-1 infection with specific humoral immune responses.

Watanabe S, Terashima K, Ohta S, Horibata S, Yajima M, Shiozawa Y, Dewan MZ, Yu Z, Ito M, Morio T, Shimizu N, Honda M, Yamamoto N.

Blood. 2007 Jan 1;109(1):212-8. Epub 2006 Sep 5.

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