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Solution conformation and thermodynamic characteristics of RNA binding by the splicing factor U2AF65.

Jenkins JL, Shen H, Green MR, Kielkopf CL.

J Biol Chem. 2008 Nov 28;283(48):33641-9. doi: 10.1074/jbc.M806297200. Epub 2008 Oct 8.


U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs.

Jenkins JL, Agrawal AA, Gupta A, Green MR, Kielkopf CL.

Nucleic Acids Res. 2013 Apr 1;41(6):3859-73. doi: 10.1093/nar/gkt046. Epub 2013 Feb 1.


Multiple U2AF65 binding sites within SF3b155: thermodynamic and spectroscopic characterization of protein-protein interactions among pre-mRNA splicing factors.

Thickman KR, Swenson MC, Kabogo JM, Gryczynski Z, Kielkopf CL.

J Mol Biol. 2006 Feb 24;356(3):664-83. Epub 2005 Dec 7.


Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF.

Mackereth CD, Madl T, Bonnal S, Simon B, Zanier K, Gasch A, Rybin V, Valcárcel J, Sattler M.

Nature. 2011 Jul 13;475(7356):408-11. doi: 10.1038/nature10171.


An extended U2AF(65)-RNA-binding domain recognizes the 3' splice site signal.

Agrawal AA, Salsi E, Chatrikhi R, Henderson S, Jenkins JL, Green MR, Ermolenko DN, Kielkopf CL.

Nat Commun. 2016 Mar 8;7:10950. doi: 10.1038/ncomms10950.


Structure, phosphorylation and U2AF65 binding of the N-terminal domain of splicing factor 1 during 3'-splice site recognition.

Zhang Y, Madl T, Bagdiul I, Kern T, Kang HS, Zou P, Mäusbacher N, Sieber SA, Krämer A, Sattler M.

Nucleic Acids Res. 2013 Jan;41(2):1343-54. doi: 10.1093/nar/gks1097. Epub 2012 Nov 21.


Alternative conformations at the RNA-binding surface of the N-terminal U2AF(65) RNA recognition motif.

Thickman KR, Sickmier EA, Kielkopf CL.

J Mol Biol. 2007 Feb 23;366(3):703-10. Epub 2006 Dec 2.


RNA induces conformational changes in the SF1/U2AF65 splicing factor complex.

Gupta A, Jenkins JL, Kielkopf CL.

J Mol Biol. 2011 Feb 4;405(5):1128-38. doi: 10.1016/j.jmb.2010.11.054. Epub 2010 Dec 10.


Crystallization and preliminary X-ray analysis of a U2AF65 variant in complex with a polypyrimidine-tract analogue by use of protein engineering.

Sickmier EA, Frato KE, Kielkopf CL.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 May 1;62(Pt 5):457-9. Epub 2006 Apr 12.


Functional recognition of the 3' splice site AG by the splicing factor U2AF35.

Wu S, Romfo CM, Nilsen TW, Green MR.

Nature. 1999 Dec 16;402(6763):832-5.


Biochemical and NMR analyses of an SF3b155-p14-U2AF-RNA interaction network involved in branch point definition during pre-mRNA splicing.

Spadaccini R, Reidt U, Dybkov O, Will C, Frank R, Stier G, Corsini L, Wahl MC, Lührmann R, Sattler M.

RNA. 2006 Mar;12(3):410-25.


The SF3b155 N-terminal domain is a scaffold important for splicing.

Cass DM, Berglund JA.

Biochemistry. 2006 Aug 22;45(33):10092-101.


A Broad range of conformations contribute to the solution ensemble of the essential splicing factor U2AF(65).

Jenkins JL, Laird KM, Kielkopf CL.

Biochemistry. 2012 Jul 3;51(26):5223-5. Epub 2012 Jun 19.


Interaction of U2AF65 RS region with pre-mRNA branch point and promotion of base pairing with U2 snRNA [corrected].

Valcárcel J, Gaur RK, Singh R, Green MR.

Science. 1996 Sep 20;273(5282):1706-9. Erratum in: Science 1996 Oct 4;274(5284):21.


hnRNP A1 proofreads 3' splice site recognition by U2AF.

Tavanez JP, Madl T, Kooshapur H, Sattler M, Valcárcel J.

Mol Cell. 2012 Feb 10;45(3):314-29. doi: 10.1016/j.molcel.2011.11.033.


A novel peptide recognition mode revealed by the X-ray structure of a core U2AF35/U2AF65 heterodimer.

Kielkopf CL, Rodionova NA, Green MR, Burley SK.

Cell. 2001 Sep 7;106(5):595-605.


Induced folding of the U2AF35 RRM upon binding to U2AF65.

Kellenberger E, Stier G, Sattler M.

FEBS Lett. 2002 Sep 25;528(1-3):171-6.


Structural basis for polypyrimidine tract recognition by the essential pre-mRNA splicing factor U2AF65.

Sickmier EA, Frato KE, Shen H, Paranawithana SR, Green MR, Kielkopf CL.

Mol Cell. 2006 Jul 7;23(1):49-59.


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