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Mutations define cross-talk between the N-terminal nucleotide-binding domain and transmembrane helix-2 of the yeast multidrug transporter Pdr5: possible conservation of a signaling interface for coupling ATP hydrolysis to drug transport.

Sauna ZE, Bohn SS, Rutledge R, Dougherty MP, Cronin S, May L, Xia D, Ambudkar SV, Golin J.

J Biol Chem. 2008 Dec 12;283(50):35010-22. doi: 10.1074/jbc.M806446200. Epub 2008 Oct 8.


The signaling interface of the yeast multidrug transporter Pdr5 adopts a cis conformation, and there are functional overlap and equivalence of the deviant and canonical Q-loop residues.

Ananthaswamy N, Rutledge R, Sauna ZE, Ambudkar SV, Dine E, Nelson E, Xia D, Golin J.

Biochemistry. 2010 Jun 1;49(21):4440-9. doi: 10.1021/bi100394j.


Evidence for a molecular diode-based mechanism in a multispecific ATP-binding cassette (ABC) exporter: SER-1368 as a gatekeeping residue in the yeast multidrug transporter Pdr5.

Mehla J, Ernst R, Moore R, Wakschlag A, Marquis MK, Ambudkar SV, Golin J.

J Biol Chem. 2014 Sep 19;289(38):26597-606. doi: 10.1074/jbc.M114.586032. Epub 2014 Aug 11.


A mutation of the H-loop selectively affects rhodamine transport by the yeast multidrug ABC transporter Pdr5.

Ernst R, Kueppers P, Klein CM, Schwarzmueller T, Kuchler K, Schmitt L.

Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5069-74. doi: 10.1073/pnas.0800191105. Epub 2008 Mar 20.


The transmission interface of the Saccharomyces cerevisiae multidrug transporter Pdr5: Val-656 located in intracellular loop 2 plays a major role in drug resistance.

Downes MT, Mehla J, Ananthaswamy N, Wakschlag A, Lamonde M, Dine E, Ambudkar SV, Golin J.

Antimicrob Agents Chemother. 2013 Feb;57(2):1025-34. doi: 10.1128/AAC.02133-12. Epub 2012 Dec 17.


Functional impact of a single mutation within the transmembrane domain of the multidrug ABC transporter Pdr5.

Kueppers P, Gupta RP, Stindt J, Smits SH, Schmitt L.

Biochemistry. 2013 Apr 2;52(13):2184-95. doi: 10.1021/bi3015778. Epub 2013 Mar 19.


Domain interactions in the yeast ATP binding cassette transporter Ycf1p: intragenic suppressor analysis of mutations in the nucleotide binding domains.

Falcón-Pérez JM, Martínez-Burgos M, Molano J, Mazón MJ, Eraso P.

J Bacteriol. 2001 Aug;183(16):4761-70.


Generating symmetry in the asymmetric ATP-binding cassette (ABC) transporter Pdr5 from Saccharomyces cerevisiae.

Gupta RP, Kueppers P, Hanekop N, Schmitt L.

J Biol Chem. 2014 May 30;289(22):15272-9. doi: 10.1074/jbc.M114.553065. Epub 2014 Apr 14.


Pdr5-mediated multidrug resistance requires the CPY-vacuolar sorting protein Vps3: are xenobiotic compounds routed from the vacuole to plasma membrane transporters for efflux?

Rutledge RM, Ghislain M, Mullins JM, de Thozée CP, Golin J.

Mol Genet Genomics. 2008 Jun;279(6):573-83. doi: 10.1007/s00438-008-0334-5. Epub 2008 Mar 8.


Purification and characterization of the N-terminal nucleotide binding domain of an ABC drug transporter of Candida albicans: uncommon cysteine 193 of Walker A is critical for ATP hydrolysis.

Jha S, Karnani N, Dhar SK, Mukhopadhayay K, Shukla S, Saini P, Mukhopadhayay G, Prasad R.

Biochemistry. 2003 Sep 16;42(36):10822-32.


Characterization of the soluble domain of the ABC7 type transporter Atm1.

Chen CA, Cowan JA.

J Biol Chem. 2003 Dec 26;278(52):52681-8. Epub 2003 Sep 26.


The deviant ATP-binding site of the multidrug efflux pump Pdr5 plays an active role in the transport cycle.

Furman C, Mehla J, Ananthaswamy N, Arya N, Kulesh B, Kovach I, Ambudkar SV, Golin J.

J Biol Chem. 2013 Oct 18;288(42):30420-31. doi: 10.1074/jbc.M113.494682. Epub 2013 Sep 9.


A mutation within the extended X loop abolished substrate-induced ATPase activity of the human liver ATP-binding cassette (ABC) transporter MDR3.

Kluth M, Stindt J, Dröge C, Linnemann D, Kubitz R, Schmitt L.

J Biol Chem. 2015 Feb 20;290(8):4896-907. doi: 10.1074/jbc.M114.588566. Epub 2014 Dec 22.


Solubilization and characterization of the overexpressed PDR5 multidrug resistance nucleotide triphosphatase of yeast.

Decottignies A, Kolaczkowski M, Balzi E, Goffeau A.

J Biol Chem. 1994 Apr 29;269(17):12797-803.


Multidrug efflux pumps: substrate selection in ATP-binding cassette multidrug efflux pumps--first come, first served?

Ernst R, Kueppers P, Stindt J, Kuchler K, Schmitt L.

FEBS J. 2010 Feb;277(3):540-9. doi: 10.1111/j.1742-4658.2009.07485.x. Epub 2009 Dec 3. Review. Erratum in: FEBS J. 2010 Jun;277(12):2726.


Functional consequences of mutations in the conserved 'signature sequence' of the ATP-binding-cassette protein MalK.

Schmees G, Stein A, Hunke S, Landmesser H, Schneider E.

Eur J Biochem. 1999 Dec;266(2):420-30.

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