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Items: 1 to 20 of 66

1.

Deletion of GSK-3beta in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation.

Kerkela R, Kockeritz L, Macaulay K, Zhou J, Doble BW, Beahm C, Greytak S, Woulfe K, Trivedi CM, Woodgett JR, Epstein JA, Force T, Huggins GS.

J Clin Invest. 2008 Nov;118(11):3609-18. doi: 10.1172/JCI36245. Epub 2008 Oct 1.

2.

Glycogen synthase kinase-3beta regulates post-myocardial infarction remodeling and stress-induced cardiomyocyte proliferation in vivo.

Woulfe KC, Gao E, Lal H, Harris D, Fan Q, Vagnozzi R, DeCaul M, Shang X, Patel S, Woodgett JR, Force T, Zhou J.

Circ Res. 2010 May 28;106(10):1635-45. doi: 10.1161/CIRCRESAHA.109.211482. Epub 2010 Apr 1.

3.

Distinct roles of GSK-3alpha and GSK-3beta phosphorylation in the heart under pressure overload.

Matsuda T, Zhai P, Maejima Y, Hong C, Gao S, Tian B, Goto K, Takagi H, Tamamori-Adachi M, Kitajima S, Sadoshima J.

Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20900-5. doi: 10.1073/pnas.0808315106. Epub 2008 Dec 23.

4.

Phosphorylation of GSK-3beta by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes.

Kawasaki Y, Kugimiya F, Chikuda H, Kamekura S, Ikeda T, Kawamura N, Saito T, Shinoda Y, Higashikawa A, Yano F, Ogasawara T, Ogata N, Hoshi K, Hofmann F, Woodgett JR, Nakamura K, Chung UI, Kawaguchi H.

J Clin Invest. 2008 Jul;118(7):2506-15. doi: 10.1172/JCI35243. Erratum in: J Clin Invest. 2008 Aug;118(8):2986.

5.

Glycogen synthase kinase-3 is essential for β-arrestin-2 complex formation and lithium-sensitive behaviors in mice.

O'Brien WT, Huang J, Buccafusca R, Garskof J, Valvezan AJ, Berry GT, Klein PS.

J Clin Invest. 2011 Sep;121(9):3756-62. doi: 10.1172/JCI45194. Epub 2011 Aug 8.

6.

Blocking cardiac growth in hypertrophic cardiomyopathy induces cardiac dysfunction and decreased survival only in males.

Luckey SW, Mansoori J, Fair K, Antos CL, Olson EN, Leinwand LA.

Am J Physiol Heart Circ Physiol. 2007 Feb;292(2):H838-45. Epub 2006 Sep 29.

7.

Tissue-specific role of glycogen synthase kinase 3beta in glucose homeostasis and insulin action.

Patel S, Doble BW, MacAulay K, Sinclair EM, Drucker DJ, Woodgett JR.

Mol Cell Biol. 2008 Oct;28(20):6314-28. doi: 10.1128/MCB.00763-08. Epub 2008 Aug 11.

8.

GSK-3alpha directly regulates beta-adrenergic signaling and the response of the heart to hemodynamic stress in mice.

Zhou J, Lal H, Chen X, Shang X, Song J, Li Y, Kerkela R, Doble BW, MacAulay K, DeCaul M, Koch WJ, Farber J, Woodgett J, Gao E, Force T.

J Clin Invest. 2010 Jul;120(7):2280-91. doi: 10.1172/JCI41407.

9.
10.

Loss of Adult Cardiac Myocyte GSK-3 Leads to Mitotic Catastrophe Resulting in Fatal Dilated Cardiomyopathy.

Zhou J, Ahmad F, Parikh S, Hoffman NE, Rajan S, Verma VK, Song J, Yuan A, Shanmughapriya S, Guo Y, Gao E, Koch W, Woodgett JR, Madesh M, Kishore R, Lal H, Force T.

Circ Res. 2016 Apr 15;118(8):1208-22. doi: 10.1161/CIRCRESAHA.116.308544. Epub 2016 Mar 14.

11.

Glycogen synthase kinase-3alpha reduces cardiac growth and pressure overload-induced cardiac hypertrophy by inhibition of extracellular signal-regulated kinases.

Zhai P, Gao S, Holle E, Yu X, Yatani A, Wagner T, Sadoshima J.

J Biol Chem. 2007 Nov 9;282(45):33181-91. Epub 2007 Sep 12.

12.
13.

Glycogen synthase kinase-3beta heterozygote knockout mice as a model of findings in postmortem schizophrenia brain or as a model of behaviors mimicking lithium action: negative results.

Bersudsky Y, Shaldubina A, Kozlovsky N, Woodgett JR, Agam G, Belmaker RH.

Behav Pharmacol. 2008 May;19(3):217-24. doi: 10.1097/FBP.0b013e3282feb099.

PMID:
18469539
14.

Glycogen synthase kinase-3beta regulates growth, calcium homeostasis, and diastolic function in the heart.

Michael A, Haq S, Chen X, Hsich E, Cui L, Walters B, Shao Z, Bhattacharya K, Kilter H, Huggins G, Andreucci M, Periasamy M, Solomon RN, Liao R, Patten R, Molkentin JD, Force T.

J Biol Chem. 2004 May 14;279(20):21383-93. Epub 2004 Mar 11.

15.

Glycogen synthase kinase-3beta is involved in the process of myocardial hypertrophy stimulated by insulin-like growth factor-1.

Seimi SK, Seinosuke K, Tsuyoshi S, Tomomi U, Tetsuaki H, Miki K, Ryuji T, Kenji I, Mitsuhiro Y.

Circ J. 2004 Mar;68(3):247-53.

16.

Novel reporter alleles of GSK-3α and GSK-3β.

Barrell WB, Szabo-Rogers HL, Liu KJ.

PLoS One. 2012;7(11):e50422. doi: 10.1371/journal.pone.0050422. Epub 2012 Nov 21.

17.

Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance.

Tanabe K, Liu Z, Patel S, Doble BW, Li L, Cras-Méneur C, Martinez SC, Welling CM, White MF, Bernal-Mizrachi E, Woodgett JR, Permutt MA.

PLoS Biol. 2008 Feb;6(2):e37. doi: 10.1371/journal.pbio.0060037.

18.

The Wnt pool of glycogen synthase kinase 3beta is critical for trophic-deprivation-induced neuronal death.

Hongisto V, Vainio JC, Thompson R, Courtney MJ, Coffey ET.

Mol Cell Biol. 2008 Mar;28(5):1515-27. doi: 10.1128/MCB.02227-06. Epub 2008 Jan 14.

19.

Inhibition of glycogen synthase kinase-3beta is sufficient for airway smooth muscle hypertrophy.

Deng H, Dokshin GA, Lei J, Goldsmith AM, Bitar KN, Fingar DC, Hershenson MB, Bentley JK.

J Biol Chem. 2008 Apr 11;283(15):10198-207. doi: 10.1074/jbc.M800624200. Epub 2008 Feb 5.

20.

GSK-3β function in bone regulates skeletal development, whole-body metabolism, and male life span.

Gillespie JR, Bush JR, Bell GI, Aubrey LA, Dupuis H, Ferron M, Kream B, DiMattia G, Patel S, Woodgett JR, Karsenty G, Hess DA, Beier F.

Endocrinology. 2013 Oct;154(10):3702-18. doi: 10.1210/en.2013-1155. Epub 2013 Jul 31.

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