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Items: 1 to 20 of 104

1.

Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice.

Wu Q, Kim KO, Sampson ER, Chen D, Awad H, O'Brien T, Puzas JE, Drissi H, Schwarz EM, O'Keefe RJ, Zuscik MJ, Rosier RN.

Arthritis Rheum. 2008 Oct;58(10):3132-44. doi: 10.1002/art.23946.

2.

Skeletal Characterization of Smurf2-Deficient Mice and In Vitro Analysis of Smurf2-Deficient Chondrocytes.

Huang H, Veien ES, Zhang H, Ayers DC, Song J.

PLoS One. 2016 Jan 27;11(1):e0148088. doi: 10.1371/journal.pone.0148088.

3.

Smurf2 induces degradation of GSK-3beta and upregulates beta-catenin in chondrocytes: a potential mechanism for Smurf2-induced degeneration of articular cartilage.

Wu Q, Huang JH, Sampson ER, Kim KO, Zuscik MJ, O'Keefe RJ, Chen D, Rosier RN.

Exp Cell Res. 2009 Aug 15;315(14):2386-98. doi: 10.1016/j.yexcr.2009.05.019.

4.

Aberrant hypertrophy in Smad3-deficient murine chondrocytes is rescued by restoring transforming growth factor beta-activated kinase 1/activating transcription factor 2 signaling: a potential clinical implication for osteoarthritis.

Li TF, Gao L, Sheu TJ, Sampson ER, Flick LM, Konttinen YT, Chen D, Schwarz EM, Zuscik MJ, Jonason JH, O'Keefe RJ.

Arthritis Rheum. 2010 Aug;62(8):2359-69. doi: 10.1002/art.27537.

5.

ADAM-12 (meltrin alpha) is involved in chondrocyte proliferation via cleavage of insulin-like growth factor binding protein 5 in osteoarthritic cartilage.

Okada A, Mochizuki S, Yatabe T, Kimura T, Shiomi T, Fujita Y, Matsumoto H, Sehara-Fujisawa A, Iwamoto Y, Okada Y.

Arthritis Rheum. 2008 Mar;58(3):778-89. doi: 10.1002/art.23262.

6.

Activation of Indian hedgehog promotes chondrocyte hypertrophy and upregulation of MMP-13 in human osteoarthritic cartilage.

Wei F, Zhou J, Wei X, Zhang J, Fleming BC, Terek R, Pei M, Chen Q, Liu T, Wei L.

Osteoarthritis Cartilage. 2012 Jul;20(7):755-63. doi: 10.1016/j.joca.2012.03.010.

7.

Beta-catenin, cartilage, and osteoarthritis.

Wu Q, Zhu M, Rosier RN, Zuscik MJ, O'Keefe RJ, Chen D.

Ann N Y Acad Sci. 2010 Mar;1192:344-50. doi: 10.1111/j.1749-6632.2009.05212.x. Review.

8.

Identification of soluble 14-3-3∊ as a novel subchondral bone mediator involved in cartilage degradation in osteoarthritis.

Priam S, Bougault C, Houard X, Gosset M, Salvat C, Berenbaum F, Jacques C.

Arthritis Rheum. 2013 Jul;65(7):1831-42. doi: 10.1002/art.37951.

9.

Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis.

Chan BY, Fuller ES, Russell AK, Smith SM, Smith MM, Jackson MT, Cake MA, Read RA, Bateman JF, Sambrook PN, Little CB.

Osteoarthritis Cartilage. 2011 Jul;19(7):874-85. doi: 10.1016/j.joca.2011.04.014.

10.

Activation of beta-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult beta-catenin conditional activation mice.

Zhu M, Tang D, Wu Q, Hao S, Chen M, Xie C, Rosier RN, O'Keefe RJ, Zuscik M, Chen D.

J Bone Miner Res. 2009 Jan;24(1):12-21. doi: 10.1359/jbmr.080901.

11.
12.

Activation of matrix metalloproteinases 2, 9, and 13 by activated protein C in human osteoarthritic cartilage chondrocytes.

Jackson MT, Moradi B, Smith MM, Jackson CJ, Little CB.

Arthritis Rheumatol. 2014 Jun;66(6):1525-36. doi: 10.1002/art.38401.

13.

Age-related alterations in TGF beta signaling as a causal factor of cartilage degeneration in osteoarthritis.

van der Kraan PM.

Biomed Mater Eng. 2014;24(1 Suppl):75-80. doi: 10.3233/BME-140976.

PMID:
24928920
14.
16.

Chondrocyte-intrinsic Smad3 represses Runx2-inducible matrix metalloproteinase 13 expression to maintain articular cartilage and prevent osteoarthritis.

Chen CG, Thuillier D, Chin EN, Alliston T.

Arthritis Rheum. 2012 Oct;64(10):3278-89. doi: 10.1002/art.34566.

17.

Modulation of TGF-beta signaling by proinflammatory cytokines in articular chondrocytes.

Roman-Blas JA, Stokes DG, Jimenez SA.

Osteoarthritis Cartilage. 2007 Dec;15(12):1367-77.

18.

Regulation of embryonic endochondral ossification by Smurf2.

Wu Q, Wang M, Zuscik MJ, Chen D, O'Keefe RJ, Rosier RN.

J Orthop Res. 2008 May;26(5):704-12. doi: 10.1002/jor.20563.

19.

Regulation of MMP-13 expression by RUNX2 and FGF2 in osteoarthritic cartilage.

Wang X, Manner PA, Horner A, Shum L, Tuan RS, Nuckolls GH.

Osteoarthritis Cartilage. 2004 Dec;12(12):963-73.

20.

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is increased in osteoarthritis and regulates chondrocyte catabolic and anabolic activities.

Long DL, Ulici V, Chubinskaya S, Loeser RF.

Osteoarthritis Cartilage. 2015 Sep;23(9):1523-31. doi: 10.1016/j.joca.2015.04.019.

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