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Degradation of a cytosolic protein requires endoplasmic reticulum-associated degradation machinery.

Metzger MB, Maurer MJ, Dancy BM, Michaelis S.

J Biol Chem. 2008 Nov 21;283(47):32302-16. doi: 10.1074/jbc.M806424200. Epub 2008 Sep 23.


Distinct machinery is required in Saccharomyces cerevisiae for the endoplasmic reticulum-associated degradation of a multispanning membrane protein and a soluble luminal protein.

Huyer G, Piluek WF, Fansler Z, Kreft SG, Hochstrasser M, Brodsky JL, Michaelis S.

J Biol Chem. 2004 Sep 10;279(37):38369-78. Epub 2004 Jul 12.


Degradation Signals for Ubiquitin-Proteasome Dependent Cytosolic Protein Quality Control (CytoQC) in Yeast.

Maurer MJ, Spear ED, Yu AT, Lee EJ, Shahzad S, Michaelis S.

G3 (Bethesda). 2016 Jul 7;6(7):1853-66. doi: 10.1534/g3.116.027953.


Hsp70 targets a cytoplasmic quality control substrate to the San1p ubiquitin ligase.

Guerriero CJ, Weiberth KF, Brodsky JL.

J Biol Chem. 2013 Jun 21;288(25):18506-20. doi: 10.1074/jbc.M113.475905. Epub 2013 May 7.


Endoplasmic Reticulum-associated Degradation of Pca1p, a Polytopic Protein, via Interaction with the Proteasome at the Membrane.

Smith N, Adle DJ, Zhao M, Qin X, Kim H, Lee J.

J Biol Chem. 2016 Jul 15;291(29):15082-92. doi: 10.1074/jbc.M116.726265. Epub 2016 May 12.


The cytoplasmic Hsp70 chaperone machinery subjects misfolded and endoplasmic reticulum import-incompetent proteins to degradation via the ubiquitin-proteasome system.

Park SH, Bolender N, Eisele F, Kostova Z, Takeuchi J, Coffino P, Wolf DH.

Mol Biol Cell. 2007 Jan;18(1):153-65. Epub 2006 Oct 25.


Use of modular substrates demonstrates mechanistic diversity and reveals differences in chaperone requirement of ERAD.

Taxis C, Hitt R, Park SH, Deak PM, Kostova Z, Wolf DH.

J Biol Chem. 2003 Sep 19;278(38):35903-13. Epub 2003 Jul 7.


Degradation signals recognized by the Ubc6p-Ubc7p ubiquitin-conjugating enzyme pair.

Gilon T, Chomsky O, Kulka RG.

Mol Cell Biol. 2000 Oct;20(19):7214-9.


The Type II Hsp40 Sis1 cooperates with Hsp70 and the E3 ligase Ubr1 to promote degradation of terminally misfolded cytosolic protein.

Summers DW, Wolfe KJ, Ren HY, Cyr DM.

PLoS One. 2013;8(1):e52099. doi: 10.1371/journal.pone.0052099. Epub 2013 Jan 16.


A Ubc7p-binding domain in Cue1p activates ER-associated protein degradation.

Kostova Z, Mariano J, Scholz S, Koenig C, Weissman AM.

J Cell Sci. 2009 May 1;122(Pt 9):1374-81. doi: 10.1242/jcs.044255. Epub 2009 Apr 14.


Previously unknown role for the ubiquitin ligase Ubr1 in endoplasmic reticulum-associated protein degradation.

Stolz A, Besser S, Hottmann H, Wolf DH.

Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15271-6. doi: 10.1073/pnas.1304928110. Epub 2013 Aug 29.


Ubiquitin ligase Hul5 is required for fragment-specific substrate degradation in endoplasmic reticulum-associated degradation.

Kohlmann S, Schäfer A, Wolf DH.

J Biol Chem. 2008 Jun 13;283(24):16374-83. doi: 10.1074/jbc.M801702200. Epub 2008 Apr 24.


Ssz1 restores endoplasmic reticulum-associated protein degradation in cells expressing defective cdc48-ufd1-npl4 complex by upregulating cdc48.

Bosis E, Salomon D, Ohayon O, Sivan G, Bar-Nun S, Rabinovich E.

Genetics. 2010 Mar;184(3):695-706. doi: 10.1534/genetics.109.111419. Epub 2009 Dec 28.


Role of Cue1p in ubiquitination and degradation at the ER surface.

Biederer T, Volkwein C, Sommer T.

Science. 1997 Dec 5;278(5344):1806-9.


A stalled retrotranslocation complex reveals physical linkage between substrate recognition and proteasomal degradation during ER-associated degradation.

Nakatsukasa K, Brodsky JL, Kamura T.

Mol Biol Cell. 2013 Jun;24(11):1765-75, S1-8. doi: 10.1091/mbc.E12-12-0907. Epub 2013 Mar 27.

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