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Items: 1 to 20 of 99

1.

Reduction with glutathione is a weakly mutagenic pathway in chromium(VI) metabolism.

Guttmann D, Poage G, Johnston T, Zhitkovich A.

Chem Res Toxicol. 2008 Nov;21(11):2188-94. doi: 10.1021/tx800265g.

2.

Genotoxicity and mutagenicity of chromium(VI)/ascorbate-generated DNA adducts in human and bacterial cells.

Quievryn G, Peterson E, Messer J, Zhitkovich A.

Biochemistry. 2003 Feb 4;42(4):1062-70.

PMID:
12549927
3.

Lower mutagenicity but higher stability of Cr-DNA adducts formed during gradual chromate activation with ascorbate.

Quievryn G, Messer J, Zhitkovich A.

Carcinogenesis. 2006 Nov;27(11):2316-21. Epub 2006 May 19.

PMID:
16714765
5.

Reductive activation with cysteine represents a chromium(III)-dependent pathway in the induction of genotoxicity by carcinogenic chromium(VI).

Zhitkovich A, Quievryn G, Messer J, Motylevich Z.

Environ Health Perspect. 2002 Oct;110 Suppl 5:729-31.

6.

Metabolism of Cr(VI) by ascorbate but not glutathione is a low oxidant-generating process.

Wong V, Armknecht S, Zhitkovich A.

J Trace Elem Med Biol. 2012 Jun;26(2-3):192-6. doi: 10.1016/j.jtemb.2012.04.016. Epub 2012 May 7.

7.

Reduction of Cr (VI) by cysteine: significance in human lymphocytes and formation of DNA damage in reactions with variable reduction rates.

Quievryn G, Goulart M, Messer J, Zhitkovich A.

Mol Cell Biochem. 2001 Jun;222(1-2):107-18.

PMID:
11678591
8.

Monitoring Cr intermediates and reactive oxygen species with fluorescent probes during chromate reduction.

DeLoughery Z, Luczak MW, Zhitkovich A.

Chem Res Toxicol. 2014 May 19;27(5):843-51. doi: 10.1021/tx500028x. Epub 2014 Mar 31.

9.

Induction of mutagenic DNA damage by chromium (VI) and glutathione.

Liu S, Dixon K.

Environ Mol Mutagen. 1996;28(2):71-9.

PMID:
8844987
10.
11.
12.

Chromium(VI) causes interstrand DNA cross-linking in vitro but shows no hypersensitivity in cross-link repair-deficient human cells.

Morse JL, Luczak MW, Zhitkovich A.

Chem Res Toxicol. 2013 Oct 21;26(10):1591-8. doi: 10.1021/tx400293s. Epub 2013 Oct 8.

13.
14.

Effects of glutathione on chromium-induced DNA crosslinking and DNA polymerase arrest.

O'Brien T, Xu J, Patierno SR.

Mol Cell Biochem. 2001 Jun;222(1-2):173-82.

PMID:
11678599
15.

Reduction of chromium(VI) by ascorbate leads to chromium-DNA binding and DNA strand breaks in vitro.

Stearns DM, Kennedy LJ, Courtney KD, Giangrande PH, Phieffer LS, Wetterhahn KE.

Biochemistry. 1995 Jan 24;34(3):910-9.

PMID:
7827049
16.

Carcinogenic chromium(VI) induces cross-linking of vitamin C to DNA in vitro and in human lung A549 cells.

Quievryn G, Messer J, Zhitkovich A.

Biochemistry. 2002 Mar 5;41(9):3156-67.

PMID:
11863455
17.

Causes of DNA single-strand breaks during reduction of chromate by glutathione in vitro and in cells.

Messer J, Reynolds M, Stoddard L, Zhitkovich A.

Free Radic Biol Med. 2006 Jun 1;40(11):1981-92. Epub 2006 Feb 20.

PMID:
16716899
18.

XPA impacts formation but not proteasome-sensitive repair of DNA-protein cross-links induced by chromate.

Zecevic A, Hagan E, Reynolds M, Poage G, Johnston T, Zhitkovich A.

Mutagenesis. 2010 Jul;25(4):381-8. doi: 10.1093/mutage/geq017. Epub 2010 Apr 21.

19.

A role for molecular oxygen in the formation of DNA damage during the reduction of the carcinogen chromium (VI) by glutathione.

Kortenkamp A, Casadevall M, Faux SP, Jenner A, Shayer RO, Woodbridge N, O'Brien P.

Arch Biochem Biophys. 1996 May 15;329(2):199-207.

PMID:
8638952
20.

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