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Codependent functions of RSK2 and the apoptosis-promoting factor TIA-1 in stress granule assembly and cell survival.

Eisinger-Mathason TS, Andrade J, Groehler AL, Clark DE, Muratore-Schroeder TL, Pasic L, Smith JA, Shabanowitz J, Hunt DF, Macara IG, Lannigan DA.

Mol Cell. 2008 Sep 5;31(5):722-36. doi: 10.1016/j.molcel.2008.06.025.


RSK2-induced stress tolerance enhances cell survival signals mediated by inhibition of GSK3β activity.

Lee CJ, Lee MH, Lee JY, Song JH, Lee HS, Cho YY.

Biochem Biophys Res Commun. 2013 Oct 11;440(1):112-8. doi: 10.1016/j.bbrc.2013.09.042. Epub 2013 Sep 17.


Characterization of nuclear localization signal in the N terminus of integrin-linked kinase-associated phosphatase (ILKAP) and its essential role in the down-regulation of RSK2 protein signaling.

Zhou W, Cao H, Yang X, Cong K, Wang W, Chen T, Yin H, Wu Z, Cai X, Liu T, Xiao J.

J Biol Chem. 2013 Mar 1;288(9):6259-71. doi: 10.1074/jbc.M112.432195. Epub 2013 Jan 17.


RSK2(Ser227) at N-terminal kinase domain is a potential therapeutic target for multiple myeloma.

Shimura Y, Kuroda J, Ri M, Nagoshi H, Yamamoto-Sugitani M, Kobayashi T, Kiyota M, Nakayama R, Mizutani S, Chinen Y, Sakamoto N, Matsumoto Y, Horiike S, Shiotsu Y, Iida S, Taniwaki M.

Mol Cancer Ther. 2012 Dec;11(12):2600-9. doi: 10.1158/1535-7163.MCT-12-0605. Epub 2012 Sep 25.


Targeting p90 ribosomal S6 kinase eliminates tumor-initiating cells by inactivating Y-box binding protein-1 in triple-negative breast cancers.

Stratford AL, Reipas K, Hu K, Fotovati A, Brough R, Frankum J, Takhar M, Watson P, Ashworth A, Lord CJ, Lasham A, Print CG, Dunn SE.

Stem Cells. 2012 Jul;30(7):1338-48. doi: 10.1002/stem.1128.


p90 ribosomal S6 kinase 2 is associated with and dephosphorylated by protein phosphatase 2Cdelta.

Doehn U, Gammeltoft S, Shen SH, Jensen CJ.

Biochem J. 2004 Sep 1;382(Pt 2):425-31.


Poliovirus infection induces the co-localization of cellular protein SRp20 with TIA-1, a cytoplasmic stress granule protein.

Fitzgerald KD, Semler BL.

Virus Res. 2013 Sep;176(1-2):223-31. doi: 10.1016/j.virusres.2013.06.012. Epub 2013 Jul 2.


RSK2 activity is regulated by its interaction with PEA-15.

Vaidyanathan H, Ramos JW.

J Biol Chem. 2003 Aug 22;278(34):32367-72. Epub 2003 Jun 9.


Polyamines inhibit the assembly of stress granules in normal intestinal epithelial cells regulating apoptosis.

Zou T, Rao JN, Liu L, Xiao L, Cui YH, Jiang Z, Ouyang M, Donahue JM, Wang JY.

Am J Physiol Cell Physiol. 2012 Jul 1;303(1):C102-11. doi: 10.1152/ajpcell.00009.2012. Epub 2012 May 2.


Phosphorylation of caspase-8 (Thr-263) by ribosomal S6 kinase 2 (RSK2) mediates caspase-8 ubiquitination and stability.

Peng C, Cho YY, Zhu F, Zhang J, Wen W, Xu Y, Yao K, Ma WY, Bode AM, Dong Z.

J Biol Chem. 2011 Mar 4;286(9):6946-54. doi: 10.1074/jbc.M110.172338. Epub 2010 Dec 23.


TAR DNA-binding protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1.

McDonald KK, Aulas A, Destroismaisons L, Pickles S, Beleac E, Camu W, Rouleau GA, Vande Velde C.

Hum Mol Genet. 2011 Apr 1;20(7):1400-10. doi: 10.1093/hmg/ddr021. Epub 2011 Jan 21.


Stress granule assembly is mediated by prion-like aggregation of TIA-1.

Gilks N, Kedersha N, Ayodele M, Shen L, Stoecklin G, Dember LM, Anderson P.

Mol Biol Cell. 2004 Dec;15(12):5383-98. Epub 2004 Sep 15.


RSK2 and its binding partners in cell proliferation, transformation and cancer development.

Cho YY.

Arch Pharm Res. 2017 Mar;40(3):291-303. doi: 10.1007/s12272-016-0880-z. Epub 2016 Dec 24. Review.


Sam68 relocalization into stress granules in response to oxidative stress through complexing with TIA-1.

Henao-Mejia J, He JJ.

Exp Cell Res. 2009 Nov 15;315(19):3381-95. doi: 10.1016/j.yexcr.2009.07.011. Epub 2009 Jul 14.


A regulatory mechanism for RSK2 NH(2)-terminal kinase activity.

Cho YY, Yao K, Pugliese A, Malakhova ML, Bode AM, Dong Z.

Cancer Res. 2009 May 15;69(10):4398-406. doi: 10.1158/0008-5472.CAN-08-4959. Epub 2009 May 12.


Hepatitis C virus (HCV) induces formation of stress granules whose proteins regulate HCV RNA replication and virus assembly and egress.

Garaigorta U, Heim MH, Boyd B, Wieland S, Chisari FV.

J Virol. 2012 Oct;86(20):11043-56. Epub 2012 Aug 1.


Computational and Biochemical Discovery of RSK2 as a Novel Target for Epigallocatechin Gallate (EGCG).

Chen H, Yao K, Chang X, Shim JH, Kim HG, Malakhova M, Kim DJ, Bode AM, Dong Z.

PLoS One. 2015 Jun 17;10(6):e0130049. doi: 10.1371/journal.pone.0130049. eCollection 2015.


Poliovirus unlinks TIA1 aggregation and mRNA stress granule formation.

White JP, Lloyd RE.

J Virol. 2011 Dec;85(23):12442-54. doi: 10.1128/JVI.05888-11. Epub 2011 Sep 28.


Attenuation of ERK/RSK2-driven NFκB gene expression and cancer cell proliferation by kurarinone, a lavandulyl flavanone isolated from Sophora flavescens ait. roots.

Berghe WV, De Naeyer A, Dijsselbloem N, David JP, De Keukeleire D, Haegeman G.

Endocr Metab Immune Disord Drug Targets. 2011 Sep 1;11(3):247-61.


Ribosomal S6 kinase 2 interacts with and phosphorylates PDZ domain-containing proteins and regulates AMPA receptor transmission.

Thomas GM, Rumbaugh GR, Harrar DB, Huganir RL.

Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15006-11. Epub 2005 Oct 10.

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