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MyD88 and Trif target Beclin 1 to trigger autophagy in macrophages.

Shi CS, Kehrl JH.

J Biol Chem. 2008 Nov 28;283(48):33175-82. doi: 10.1074/jbc.M804478200. Epub 2008 Sep 4.


Signaling of apoptosis through TLRs critically involves toll/IL-1 receptor domain-containing adapter inducing IFN-beta, but not MyD88, in bacteria-infected murine macrophages.

Ruckdeschel K, Pfaffinger G, Haase R, Sing A, Weighardt H, Häcker G, Holzmann B, Heesemann J.

J Immunol. 2004 Sep 1;173(5):3320-8.


Endotoxin tolerance dysregulates MyD88- and Toll/IL-1R domain-containing adapter inducing IFN-beta-dependent pathways and increases expression of negative regulators of TLR signaling.

Piao W, Song C, Chen H, Diaz MA, Wahl LM, Fitzgerald KA, Li L, Medvedev AE.

J Leukoc Biol. 2009 Oct;86(4):863-75. doi: 10.1189/jlb.0309189. Epub 2009 Aug 5.


TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy.

Shi CS, Kehrl JH.

Sci Signal. 2010 May 25;3(123):ra42. doi: 10.1126/scisignal.2000751.


Signaling pathway of autophagy associated with innate immunity.

Xu Y, Liu XD, Gong X, Eissa NT.

Autophagy. 2008 Jan;4(1):110-2. Epub 2007 Oct 31.


Melatonin modulates TLR4-mediated inflammatory genes through MyD88- and TRIF-dependent signaling pathways in lipopolysaccharide-stimulated RAW264.7 cells.

Xia MZ, Liang YL, Wang H, Chen X, Huang YY, Zhang ZH, Chen YH, Zhang C, Zhao M, Xu DX, Song LH.

J Pineal Res. 2012 Nov;53(4):325-34. doi: 10.1111/j.1600-079X.2012.01002.x. Epub 2012 Apr 27.


Innate immune responses to endosymbiotic Wolbachia bacteria in Brugia malayi and Onchocerca volvulus are dependent on TLR2, TLR6, MyD88, and Mal, but not TLR4, TRIF, or TRAM.

Hise AG, Daehnel K, Gillette-Ferguson I, Cho E, McGarry HF, Taylor MJ, Golenbock DT, Fitzgerald KA, Kazura JW, Pearlman E.

J Immunol. 2007 Jan 15;178(2):1068-76.


MYD88-dependent and -independent activation of TREM-1 via specific TLR ligands.

Zheng H, Heiderscheidt CA, Joo M, Gao X, Knezevic N, Mehta D, Sadikot RT.

Eur J Immunol. 2010 Jan;40(1):162-71. doi: 10.1002/eji.200839156.


Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b.

Han C, Jin J, Xu S, Liu H, Li N, Cao X.

Nat Immunol. 2010 Aug;11(8):734-42. doi: 10.1038/ni.1908. Epub 2010 Jul 18.


Traf6 and A20 differentially regulate TLR4-induced autophagy by affecting the ubiquitination of Beclin 1.

Shi CS, Kehrl JH.

Autophagy. 2010 Oct;6(7):986-7. doi: 10.4161/auto.6.7.13288. Epub 2010 Oct 9.


Distinct single-cell signaling characteristics are conferred by the MyD88 and TRIF pathways during TLR4 activation.

Cheng Z, Taylor B, Ourthiague DR, Hoffmann A.

Sci Signal. 2015 Jul 14;8(385):ra69. doi: 10.1126/scisignal.aaa5208.


TLR3-mediated IFN-β gene induction is negatively regulated by the TLR adaptor MyD88 adaptor-like.

Siednienko J, Halle A, Nagpal K, Golenbock DT, Miggin SM.

Eur J Immunol. 2010 Nov;40(11):3150-60. doi: 10.1002/eji.201040547. Epub 2010 Oct 19.


Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage.

Lin S, Yin Q, Zhong Q, Lv FL, Zhou Y, Li JQ, Wang JZ, Su BY, Yang QW.

J Neuroinflammation. 2012 Mar 6;9:46. doi: 10.1186/1742-2094-9-46.


Phosphatase PTP1B negatively regulates MyD88- and TRIF-dependent proinflammatory cytokine and type I interferon production in TLR-triggered macrophages.

Xu H, An H, Hou J, Han C, Wang P, Yu Y, Cao X.

Mol Immunol. 2008 Aug;45(13):3545-52. doi: 10.1016/j.molimm.2008.05.006. Epub 2008 Jun 20.


TLR4-mediated AKT activation is MyD88/TRIF dependent and critical for induction of oxidative phosphorylation and mitochondrial transcription factor A in murine macrophages.

Bauerfeld CP, Rastogi R, Pirockinaite G, Lee I, Hüttemann M, Monks B, Birnbaum MJ, Franchi L, Nuñez G, Samavati L.

J Immunol. 2012 Mar 15;188(6):2847-57. doi: 10.4049/jimmunol.1102157. Epub 2012 Feb 6.


Recipient Toll-like receptors contribute to chronic graft dysfunction by both MyD88- and TRIF-dependent signaling.

Wang S, Schmaderer C, Kiss E, Schmidt C, Bonrouhi M, Porubsky S, Gretz N, Schaefer L, Kirschning CJ, Popovic ZV, Gröne HJ.

Dis Model Mech. 2010 Jan-Feb;3(1-2):92-103. doi: 10.1242/dmm.003533. Epub 2009 Dec 28.


Differential requirements of MyD88 and TRIF pathways in TLR4-mediated immune responses in murine B cells.

Yanagibashi T, Nagai Y, Watanabe Y, Ikutani M, Hirai Y, Takatsu K.

Immunol Lett. 2015 Jan;163(1):22-31. doi: 10.1016/j.imlet.2014.11.012. Epub 2014 Nov 22.


Functional interaction of heat shock protein 90 and Beclin 1 modulates Toll-like receptor-mediated autophagy.

Xu C, Liu J, Hsu LC, Luo Y, Xiang R, Chuang TH.

FASEB J. 2011 Aug;25(8):2700-10. doi: 10.1096/fj.10-167676. Epub 2011 May 4.

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