Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 132


HtrA2/Omi terminates cytomegalovirus infection and is controlled by the viral mitochondrial inhibitor of apoptosis (vMIA).

McCormick AL, Roback L, Mocarski ES.

PLoS Pathog. 2008 May 9;4(5):e1000063. doi: 10.1371/journal.ppat.1000063.


Multiplicity-dependent activation of a serine protease-dependent cytomegalovirus-associated programmed cell death pathway.

McCormick AL, Roback L, Wynn G, Mocarski ES.

Virology. 2013 Jan 20;435(2):250-7. doi: 10.1016/j.virol.2012.08.042. Epub 2012 Nov 14.


vMIA, a viral inhibitor of apoptosis targeting mitochondria.

Goldmacher VS.

Biochimie. 2002 Feb-Mar;84(2-3):177-85. Review.


Characterization of a novel and specific inhibitor for the pro-apoptotic protease Omi/HtrA2.

Cilenti L, Lee Y, Hess S, Srinivasula S, Park KM, Junqueira D, Davis H, Bonventre JV, Alnemri ES, Zervos AS.

J Biol Chem. 2003 Mar 28;278(13):11489-94. Epub 2003 Jan 15.


Role of Omi/HtrA2 in apoptotic cell death after myocardial ischemia and reperfusion.

Liu HR, Gao E, Hu A, Tao L, Qu Y, Most P, Koch WJ, Christopher TA, Lopez BL, Alnemri ES, Zervos AS, Ma XL.

Circulation. 2005 Jan 4;111(1):90-6. Epub 2004 Dec 20.


Cytopathic effects of the cytomegalovirus-encoded apoptosis inhibitory protein vMIA.

Poncet D, Pauleau AL, Szabadkai G, Vozza A, Scholz SR, Le Bras M, Brière JJ, Jalil A, Le Moigne R, Brenner C, Hahn G, Wittig I, Schägger H, Lemaire C, Bianchi K, Souquère S, Pierron G, Rustin P, Goldmacher VS, Rizzuto R, Palmieri F, Kroemer G.

J Cell Biol. 2006 Sep 25;174(7):985-96. Epub 2006 Sep 18.


Participation of Omi Htra2 serine-protease activity in the apoptosis induced by cisplatin on SW480 colon cancer cells.

Pruefer FG, Lizarraga F, Maldonado V, Melendez-Zajgla J.

J Chemother. 2008 Jun;20(3):348-54.


Omi/HtrA2 Regulates a Mitochondria-Dependent Apoptotic Pathway in a Murine Model of Septic Encephalopathy.

Wang P, Hu Y, Yao D, Li Y.

Cell Physiol Biochem. 2018;49(6):2163-2173. doi: 10.1159/000493819. Epub 2018 Oct 4.


Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2.

Srinivasula SM, Gupta S, Datta P, Zhang Z, Hegde R, Cheong N, Fernandes-Alnemri T, Alnemri ES.

J Biol Chem. 2003 Aug 22;278(34):31469-72. Epub 2003 Jun 30.


Omi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15.

Trencia A, Fiory F, Maitan MA, Vito P, Barbagallo AP, Perfetti A, Miele C, Ungaro P, Oriente F, Cilenti L, Zervos AS, Formisano P, Beguinot F.

J Biol Chem. 2004 Nov 5;279(45):46566-72. Epub 2004 Aug 24.


Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase and increased mitophagy.

Cilenti L, Ambivero CT, Ward N, Alnemri ES, Germain D, Zervos AS.

Biochim Biophys Acta. 2014 Jul;1843(7):1295-307. doi: 10.1016/j.bbamcr.2014.03.027. Epub 2014 Apr 5.


The serine protease Omi/HtrA2 is involved in XIAP cleavage and in neuronal cell death following focal cerebral ischemia/reperfusion.

Althaus J, Siegelin MD, Dehghani F, Cilenti L, Zervos AS, Rami A.

Neurochem Int. 2007 Jan;50(1):172-80. Epub 2006 Sep 15.


Akt attenuation of the serine protease activity of HtrA2/Omi through phosphorylation of serine 212.

Yang L, Sun M, Sun XM, Cheng GZ, Nicosia SV, Cheng JQ.

J Biol Chem. 2007 Apr 13;282(15):10981-7. Epub 2007 Feb 20. Retraction in: J Biol Chem. 2016 Oct 21;291(43):22843.


Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways.

Suzuki Y, Takahashi-Niki K, Akagi T, Hashikawa T, Takahashi R.

Cell Death Differ. 2004 Feb;11(2):208-16.


Viral mitochondria-localized inhibitor of apoptosis (UL37 exon 1 protein) does not protect human neural precursor cells from human cytomegalovirus-induced cell death.

Hildreth RL, Bullough MD, Zhang A, Chen HL, Schwartz PH, Panchision DM, Colberg-Poley AM.

J Gen Virol. 2012 Nov;93(Pt 11):2436-46. doi: 10.1099/vir.0.044784-0. Epub 2012 Aug 8.


THAP5 is a human cardiac-specific inhibitor of cell cycle that is cleaved by the proapoptotic Omi/HtrA2 protease during cell death.

Balakrishnan MP, Cilenti L, Mashak Z, Popat P, Alnemri ES, Zervos AS.

Am J Physiol Heart Circ Physiol. 2009 Aug;297(2):H643-53. doi: 10.1152/ajpheart.00234.2009. Epub 2009 Jun 5.


The mitochondrial serine protease HtrA2/Omi: an overview.

Vande Walle L, Lamkanfi M, Vandenabeele P.

Cell Death Differ. 2008 Mar;15(3):453-60. doi: 10.1038/sj.cdd.4402291. Epub 2008 Jan 4. Review.

Supplemental Content

Support Center