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Items: 1 to 20 of 53


Activation of ATR and related PIKKs.

Mordes DA, Cortez D.

Cell Cycle. 2008 Sep 15;7(18):2809-12. Epub 2008 Sep 30.


TopBP1 activates ATR through ATRIP and a PIKK regulatory domain.

Mordes DA, Glick GG, Zhao R, Cortez D.

Genes Dev. 2008 Jun 1;22(11):1478-89. doi: 10.1101/gad.1666208.


Tel2 regulates the stability of PI3K-related protein kinases.

Takai H, Wang RC, Takai KK, Yang H, de Lange T.

Cell. 2007 Dec 28;131(7):1248-59.


A tale of two tails: activation of DNA damage checkpoint kinase Mec1/ATR by the 9-1-1 clamp and by Dpb11/TopBP1.

Navadgi-Patil VM, Burgers PM.

DNA Repair (Amst). 2009 Sep 2;8(9):996-1003. doi: 10.1016/j.dnarep.2009.03.011. Epub 2009 May 22. Review.


Function of a conserved checkpoint recruitment domain in ATRIP proteins.

Ball HL, Ehrhardt MR, Mordes DA, Glick GG, Chazin WJ, Cortez D.

Mol Cell Biol. 2007 May;27(9):3367-77. Epub 2007 Mar 5.


How ATR turns on: TopBP1 goes on ATRIP with ATR.

Burrows AE, Elledge SJ.

Genes Dev. 2008 Jun 1;22(11):1416-21. doi: 10.1101/gad.1685108.


Integrated regulation of PIKK-mediated stress responses by AAA+ proteins RUVBL1 and RUVBL2.

Izumi N, Yamashita A, Ohno S.

Nucleus. 2012 Jan-Feb;3(1):29-43. doi: 10.4161/nucl.18926. Review.


The unstructured C-terminal tail of the 9-1-1 clamp subunit Ddc1 activates Mec1/ATR via two distinct mechanisms.

Navadgi-Patil VM, Burgers PM.

Mol Cell. 2009 Dec 11;36(5):743-53. doi: 10.1016/j.molcel.2009.10.014.


Emerging common themes in regulation of PIKKs and PI3Ks.

Lempiäinen H, Halazonetis TD.

EMBO J. 2009 Oct 21;28(20):3067-73. doi: 10.1038/emboj.2009.281. Epub 2009 Sep 24. Review.


Dpb11 activates the Mec1-Ddc2 complex.

Mordes DA, Nam EA, Cortez D.

Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18730-4. doi: 10.1073/pnas.0806621105. Epub 2008 Nov 21.


TopBP1 activates the ATR-ATRIP complex.

Kumagai A, Lee J, Yoo HY, Dunphy WG.

Cell. 2006 Mar 10;124(5):943-55.


The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR.

Lee J, Kumagai A, Dunphy WG.

J Biol Chem. 2007 Sep 21;282(38):28036-44. Epub 2007 Jul 18.


PIKKs--the solenoid nest where partners and kinases meet.

Baretić D, Williams RL.

Curr Opin Struct Biol. 2014 Dec;29:134-42. doi: 10.1016/ Epub 2014 Dec 3. Review.


Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM.

Yoo HY, Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG.

J Biol Chem. 2007 Jun 15;282(24):17501-6. Epub 2007 Apr 19.


Clamping the Mec1/ATR checkpoint kinase into action.

Majka J, Burgers PM.

Cell Cycle. 2007 May 15;6(10):1157-60. Epub 2007 May 1.


The role of NBS1 in the modulation of PIKK family proteins ATM and ATR in the cellular response to DNA damage.

Zhou J, Lim CU, Li JJ, Cai L, Zhang Y.

Cancer Lett. 2006 Nov 8;243(1):9-15. Epub 2006 Mar 10. Review.


The RNA surveillance protein SMG1 activates p53 in response to DNA double-strand breaks but not exogenously oxidized mRNA.

Gewandter JS, Bambara RA, O'Reilly MA.

Cell Cycle. 2011 Aug 1;10(15):2561-7. Epub 2011 Aug 1.


Cell-cycle-specific activators of the Mec1/ATR checkpoint kinase.

Navadgi-Patil VM, Burgers PM.

Biochem Soc Trans. 2011 Apr;39(2):600-5. doi: 10.1042/BST0390600. Review.


ATR autophosphorylation as a molecular switch for checkpoint activation.

Liu S, Shiotani B, Lahiri M, Maréchal A, Tse A, Leung CC, Glover JN, Yang XH, Zou L.

Mol Cell. 2011 Jul 22;43(2):192-202. doi: 10.1016/j.molcel.2011.06.019.

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