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Items: 1 to 20 of 168

1.

Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation.

Fluhrer R, Fukumori A, Martin L, Grammer G, Haug-Kröper M, Klier B, Winkler E, Kremmer E, Condron MM, Teplow DB, Steiner H, Haass C.

J Biol Chem. 2008 Oct 31;283(44):30121-8. doi: 10.1074/jbc.M806092200. Epub 2008 Sep 3.

2.

A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b.

Fluhrer R, Grammer G, Israel L, Condron MM, Haffner C, Friedmann E, Böhland C, Imhof A, Martoglio B, Teplow DB, Haass C.

Nat Cell Biol. 2006 Aug;8(8):894-6. Epub 2006 Jul 9.

3.

Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.

Steiner H, Capell A, Leimer U, Haass C.

Eur Arch Psychiatry Clin Neurosci. 1999;249(6):266-70. Review.

PMID:
10653281
4.

The α-helical content of the transmembrane domain of the British dementia protein-2 (Bri2) determines its processing by signal peptide peptidase-like 2b (SPPL2b).

Fluhrer R, Martin L, Klier B, Haug-Kröper M, Grammer G, Nuscher B, Haass C.

J Biol Chem. 2012 Feb 10;287(7):5156-63. doi: 10.1074/jbc.M111.328104. Epub 2011 Dec 22.

5.

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling.

Steiner H, Duff K, Capell A, Romig H, Grim MG, Lincoln S, Hardy J, Yu X, Picciano M, Fechteler K, Citron M, Kopan R, Pesold B, Keck S, Baader M, Tomita T, Iwatsubo T, Baumeister R, Haass C.

J Biol Chem. 1999 Oct 1;274(40):28669-73.

6.

Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b.

Martin L, Fluhrer R, Reiss K, Kremmer E, Saftig P, Haass C.

J Biol Chem. 2008 Jan 18;283(3):1644-52. Epub 2007 Oct 25.

7.
8.

Mechanism of gamma-secretase cleavage activation: is gamma-secretase regulated through autoinhibition involving the presenilin-1 exon 9 loop?

Knappenberger KS, Tian G, Ye X, Sobotka-Briner C, Ghanekar SV, Greenberg BD, Scott CW.

Biochemistry. 2004 May 25;43(20):6208-18.

PMID:
15147205
9.

Proteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases.

Fleck D, Voss M, Brankatschk B, Giudici C, Hampel H, Schwenk B, Edbauer D, Fukumori A, Steiner H, Kremmer E, Haug-Kröper M, Rossner MJ, Fluhrer R, Willem M, Haass C.

J Biol Chem. 2016 Jan 1;291(1):318-33. doi: 10.1074/jbc.M115.697995. Epub 2015 Nov 16.

10.

Generation of C-terminally truncated amyloid-beta peptides is dependent on gamma-secretase activity.

Beher D, Wrigley JD, Owens AP, Shearman MS.

J Neurochem. 2002 Aug;82(3):563-75.

12.

The mechanism of gamma-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals.

Takasugi N, Takahashi Y, Morohashi Y, Tomita T, Iwatsubo T.

J Biol Chem. 2002 Dec 20;277(51):50198-205. Epub 2002 Oct 17.

13.

Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin-dependent generation.

Fluhrer R, Multhaup G, Schlicksupp A, Okochi M, Takeda M, Lammich S, Willem M, Westmeyer G, Bode W, Walter J, Haass C.

J Biol Chem. 2003 Feb 21;278(8):5531-8. Epub 2002 Dec 5.

14.
15.

Enzymatic characteristics of I213T mutant presenilin-1/gamma-secretase in cell models and knock-in mouse brains: familial Alzheimer disease-linked mutation impairs gamma-site cleavage of amyloid precursor protein C-terminal fragment beta.

Shimojo M, Sahara N, Mizoroki T, Funamoto S, Morishima-Kawashima M, Kudo T, Takeda M, Ihara Y, Ichinose H, Takashima A.

J Biol Chem. 2008 Jun 13;283(24):16488-96. doi: 10.1074/jbc.M801279200. Epub 2008 Apr 21.

16.
17.

Alzheimer presenilin-1 mutations dramatically reduce trimming of long amyloid β-peptides (Aβ) by γ-secretase to increase 42-to-40-residue Aβ.

Fernandez MA, Klutkowski JA, Freret T, Wolfe MS.

J Biol Chem. 2014 Nov 7;289(45):31043-52. doi: 10.1074/jbc.M114.581165. Epub 2014 Sep 19.

18.

A presenilin-independent aspartyl protease prefers the gamma-42 site cleavage.

Lai MT, Crouthamel MC, DiMuzio J, Pietrak BL, Donoviel DB, Bernstein A, Gardell SJ, Li YM, Hazuda D.

J Neurochem. 2006 Jan;96(1):118-25. Epub 2005 Nov 21.

19.
20.

Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis.

Fukumori A, Fluhrer R, Steiner H, Haass C.

J Neurosci. 2010 Jun 9;30(23):7853-62. doi: 10.1523/JNEUROSCI.1443-10.2010.

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