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Items: 1 to 20 of 93


Clozapine and sulpiride but not haloperidol or olanzapine activate brain DNA demethylation.

Dong E, Nelson M, Grayson DR, Costa E, Guidotti A.

Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13614-9. doi: 10.1073/pnas.0805493105. Epub 2008 Aug 29.


Antipsychotic subtypes can be characterized by differences in their ability to modify GABAergic promoter methylation.

Dong E, Grayson DR, Guidotti A, Costa E.

Epigenomics. 2009 Oct;1(1):201-11. doi: 10.2217/epi.09.2.


Characterization of the action of antipsychotic subtypes on valproate-induced chromatin remodeling.

Guidotti A, Dong E, Kundakovic M, Satta R, Grayson DR, Costa E.

Trends Pharmacol Sci. 2009 Feb;30(2):55-60. doi: 10.1016/ Epub 2008 Dec 26.


Histone hyperacetylation induces demethylation of reelin and 67-kDa glutamic acid decarboxylase promoters.

Dong E, Guidotti A, Grayson DR, Costa E.

Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4676-81. Epub 2007 Mar 7.


Reelin and glutamic acid decarboxylase67 promoter remodeling in an epigenetic methionine-induced mouse model of schizophrenia.

Dong E, Agis-Balboa RC, Simonini MV, Grayson DR, Costa E, Guidotti A.

Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12578-83. Epub 2005 Aug 19.


Valproate corrects the schizophrenia-like epigenetic behavioral modifications induced by methionine in mice.

Tremolizzo L, Doueiri MS, Dong E, Grayson DR, Davis J, Pinna G, Tueting P, Rodriguez-Menendez V, Costa E, Guidotti A.

Biol Psychiatry. 2005 Mar 1;57(5):500-9.


The reelin and GAD67 promoters are activated by epigenetic drugs that facilitate the disruption of local repressor complexes.

Kundakovic M, Chen Y, Guidotti A, Grayson DR.

Mol Pharmacol. 2009 Feb;75(2):342-54. doi: 10.1124/mol.108.051763. Epub 2008 Nov 24.


An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability.

Tremolizzo L, Carboni G, Ruzicka WB, Mitchell CP, Sugaya I, Tueting P, Sharma R, Grayson DR, Costa E, Guidotti A.

Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):17095-100. Epub 2002 Dec 12.


Valproate induces DNA demethylation in nuclear extracts from adult mouse brain.

Dong E, Chen Y, Gavin DP, Grayson DR, Guidotti A.

Epigenetics. 2010 Nov-Dec;5(8):730-5. doi: 10.4161/epi.5.8.13053. Epub 2010 Nov 1.


DNA-methyltransferase1 (DNMT1) binding to CpG rich GABAergic and BDNF promoters is increased in the brain of schizophrenia and bipolar disorder patients.

Dong E, Ruzicka WB, Grayson DR, Guidotti A.

Schizophr Res. 2015 Sep;167(1-3):35-41. doi: 10.1016/j.schres.2014.10.030. Epub 2014 Dec 2.


GABAergic promoter hypermethylation as a model to study the neurochemistry of schizophrenia vulnerability.

Costa E, Chen Y, Dong E, Grayson DR, Kundakovic M, Maloku E, Ruzicka W, Satta R, Veldic M, Zhubi A, Guidotti A.

Expert Rev Neurother. 2009 Jan;9(1):87-98. doi: 10.1586/14737175.9.1.87. Review.


Epigenetic modifications of GABAergic interneurons are associated with the schizophrenia-like phenotype induced by prenatal stress in mice.

Matrisciano F, Tueting P, Dalal I, Kadriu B, Grayson DR, Davis JM, Nicoletti F, Guidotti A.

Neuropharmacology. 2013 May;68:184-94. doi: 10.1016/j.neuropharm.2012.04.013. Epub 2012 Apr 28.


DNA methyltransferase inhibitors coordinately induce expression of the human reelin and glutamic acid decarboxylase 67 genes.

Kundakovic M, Chen Y, Costa E, Grayson DR.

Mol Pharmacol. 2007 Mar;71(3):644-53. Epub 2006 Oct 25.


Epigenetic GABAergic targets in schizophrenia and bipolar disorder.

Guidotti A, Auta J, Chen Y, Davis JM, Dong E, Gavin DP, Grayson DR, Matrisciano F, Pinna G, Satta R, Sharma RP, Tremolizzo L, Tueting P.

Neuropharmacology. 2011 Jun;60(7-8):1007-16. doi: 10.1016/j.neuropharm.2010.10.021. Epub 2010 Nov 11. Review.


DNA methyltransferase 1 regulates reelin mRNA expression in mouse primary cortical cultures.

Noh JS, Sharma RP, Veldic M, Salvacion AA, Jia X, Chen Y, Costa E, Guidotti A, Grayson DR.

Proc Natl Acad Sci U S A. 2005 Feb 1;102(5):1749-54. Epub 2005 Jan 25.


The human reelin gene: transcription factors (+), repressors (-) and the methylation switch (+/-) in schizophrenia.

Grayson DR, Chen Y, Costa E, Dong E, Guidotti A, Kundakovic M, Sharma RP.

Pharmacol Ther. 2006 Jul;111(1):272-86. Epub 2006 Mar 30. Review.


The benzamide MS-275 is a potent, long-lasting brain region-selective inhibitor of histone deacetylases.

Simonini MV, Camargo LM, Dong E, Maloku E, Veldic M, Costa E, Guidotti A.

Proc Natl Acad Sci U S A. 2006 Jan 31;103(5):1587-92. Epub 2006 Jan 23.


Chronic psychotropic drug treatment causes differential expression of Reelin signaling system in frontal cortex of rats.

Fatemi SH, Reutiman TJ, Folsom TD.

Schizophr Res. 2009 Jun;111(1-3):138-52. doi: 10.1016/j.schres.2009.03.002. Epub 2009 Apr 9.


Histone deacetylase inhibitors decrease reelin promoter methylation in vitro.

Mitchell CP, Chen Y, Kundakovic M, Costa E, Grayson DR.

J Neurochem. 2005 Apr;93(2):483-92.


DNA-methyltransferase 1 mRNA is selectively overexpressed in telencephalic GABAergic interneurons of schizophrenia brains.

Veldic M, Caruncho HJ, Liu WS, Davis J, Satta R, Grayson DR, Guidotti A, Costa E.

Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):348-53. Epub 2003 Dec 18.

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