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Items: 1 to 20 of 96


Models of toxic beta-sheet channels of protegrin-1 suggest a common subunit organization motif shared with toxic alzheimer beta-amyloid ion channels.

Jang H, Ma B, Lal R, Nussinov R.

Biophys J. 2008 Nov 15;95(10):4631-42. doi: 10.1529/biophysj.108.134551. Epub 2008 Aug 15.


Misfolded amyloid ion channels present mobile beta-sheet subunits in contrast to conventional ion channels.

Jang H, Arce FT, Capone R, Ramachandran S, Lal R, Nussinov R.

Biophys J. 2009 Dec 2;97(11):3029-37. doi: 10.1016/j.bpj.2009.09.014.


Structural convergence among diverse, toxic beta-sheet ion channels.

Jang H, Teran Arce F, Ramachandran S, Capone R, Lal R, Nussinov R.

J Phys Chem B. 2010 Jul 29;114(29):9445-51. doi: 10.1021/jp104073k.


Probing ion channel activity of human islet amyloid polypeptide (amylin).

Zhao J, Luo Y, Jang H, Yu X, Wei G, Nussinov R, Zheng J.

Biochim Biophys Acta. 2012 Dec;1818(12):3121-30. doi: 10.1016/j.bbamem.2012.08.012. Epub 2012 Aug 23.


β-Barrel topology of Alzheimer's β-amyloid ion channels.

Jang H, Arce FT, Ramachandran S, Capone R, Lal R, Nussinov R.

J Mol Biol. 2010 Dec 17;404(5):917-34. doi: 10.1016/j.jmb.2010.10.025. Epub 2010 Oct 21.


Antimicrobial protegrin-1 forms ion channels: molecular dynamic simulation, atomic force microscopy, and electrical conductance studies.

Capone R, Mustata M, Jang H, Arce FT, Nussinov R, Lal R.

Biophys J. 2010 Jun 2;98(11):2644-52. doi: 10.1016/j.bpj.2010.02.024.


Antimicrobial protegrin-1 forms amyloid-like fibrils with rapid kinetics suggesting a functional link.

Jang H, Arce FT, Mustata M, Ramachandran S, Capone R, Nussinov R, Lal R.

Biophys J. 2011 Apr 6;100(7):1775-83. doi: 10.1016/j.bpj.2011.01.072.


Interactions of Aβ25-35 β-barrel-like oligomers with anionic lipid bilayer and resulting membrane leakage: an all-atom molecular dynamics study.

Chang Z, Luo Y, Zhang Y, Wei G.

J Phys Chem B. 2011 Feb 10;115(5):1165-74. doi: 10.1021/jp107558e. Epub 2010 Dec 30.


Probing structural features of Alzheimer's amyloid-β pores in bilayers using site-specific amino acid substitutions.

Capone R, Jang H, Kotler SA, Kagan BL, Nussinov R, Lal R.

Biochemistry. 2012 Jan 24;51(3):776-85. doi: 10.1021/bi2017427. Epub 2012 Jan 12.


Membrane-dependent oligomeric structure and pore formation of a beta-hairpin antimicrobial peptide in lipid bilayers from solid-state NMR.

Mani R, Cady SD, Tang M, Waring AJ, Lehrer RI, Hong M.

Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16242-7. Epub 2006 Oct 23.


Interaction of protegrin-1 with lipid bilayers: membrane thinning effect.

Jang H, Ma B, Woolf TB, Nussinov R.

Biophys J. 2006 Oct 15;91(8):2848-59. Epub 2006 Jul 21.


Effects of point substitutions on the structure of toxic Alzheimer's β-amyloid channels: atomic force microscopy and molecular dynamics simulations.

Connelly L, Jang H, Arce FT, Ramachandran S, Kagan BL, Nussinov R, Lal R.

Biochemistry. 2012 Apr 10;51(14):3031-8. doi: 10.1021/bi300257e. Epub 2012 Mar 28.


Theoretical models of the ion channel structure of amyloid beta-protein.

Durell SR, Guy HR, Arispe N, Rojas E, Pollard HB.

Biophys J. 1994 Dec;67(6):2137-45.


Solid-state NMR investigations of peptide-lipid interaction and orientation of a beta-sheet antimicrobial peptide, protegrin.

Yamaguchi S, Hong T, Waring A, Lehrer RI, Hong M.

Biochemistry. 2002 Aug 6;41(31):9852-62.


Computational Methods for Structural and Functional Studies of Alzheimer's Amyloid Ion Channels.

Jang H, Arce FT, Lee J, Gillman AL, Ramachandran S, Kagan BL, Lal R, Nussinov R.

Methods Mol Biol. 2016;1345:251-68. doi: 10.1007/978-1-4939-2978-8_16.


Membrane interactions and pore formation by the antimicrobial peptide protegrin.

Lazaridis T, He Y, Prieto L.

Biophys J. 2013 Feb 5;104(3):633-42. doi: 10.1016/j.bpj.2012.12.038.


Structure of the antimicrobial beta-hairpin peptide protegrin-1 in a DLPC lipid bilayer investigated by molecular dynamics simulation.

Khandelia H, Kaznessis YN.

Biochim Biophys Acta. 2007 Mar;1768(3):509-20. Epub 2006 Dec 15. Erratum in: Biochim Biophys Acta. 2010 Aug;1798(8):1623.


On the nature of antimicrobial activity: a model for protegrin-1 pores.

Langham AA, Ahmad AS, Kaznessis YN.

J Am Chem Soc. 2008 Apr 2;130(13):4338-46. doi: 10.1021/ja0780380. Epub 2008 Mar 12.

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