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Items: 1 to 20 of 134

1.

Conformational switch of syntaxin-1 controls synaptic vesicle fusion.

Gerber SH, Rah JC, Min SW, Liu X, de Wit H, Dulubova I, Meyer AC, Rizo J, Arancillo M, Hammer RE, Verhage M, Rosenmund C, Südhof TC.

Science. 2008 Sep 12;321(5895):1507-10. doi: 10.1126/science.1163174. Epub 2008 Aug 14.

2.

Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming.

Deák F, Xu Y, Chang WP, Dulubova I, Khvotchev M, Liu X, Südhof TC, Rizo J.

J Cell Biol. 2009 Mar 9;184(5):751-64. doi: 10.1083/jcb.200812026. Epub 2009 Mar 2.

3.

Syntaxin-1 N-peptide and Habc-domain perform distinct essential functions in synaptic vesicle fusion.

Zhou P, Pang ZP, Yang X, Zhang Y, Rosenmund C, Bacaj T, Südhof TC.

EMBO J. 2013 Jan 9;32(1):159-71. doi: 10.1038/emboj.2012.307. Epub 2012 Nov 27.

4.

Dual modes of Munc18-1/SNARE interactions are coupled by functionally critical binding to syntaxin-1 N terminus.

Khvotchev M, Dulubova I, Sun J, Dai H, Rizo J, Südhof TC.

J Neurosci. 2007 Nov 7;27(45):12147-55.

5.

Syntaxin N-terminal peptide motif is an initiation factor for the assembly of the SNARE-Sec1/Munc18 membrane fusion complex.

Rathore SS, Bend EG, Yu H, Hammarlund M, Jorgensen EM, Shen J.

Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22399-406. doi: 10.1073/pnas.1012997108. Epub 2010 Dec 7.

6.

An extended helical conformation in domain 3a of Munc18-1 provides a template for SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) complex assembly.

Parisotto D, Pfau M, Scheutzow A, Wild K, Mayer MP, Malsam J, Sinning I, Söllner TH.

J Biol Chem. 2014 Apr 4;289(14):9639-50. doi: 10.1074/jbc.M113.514273. Epub 2014 Feb 14.

7.

Conformational change of syntaxin linker region induced by Munc13s initiates SNARE complex formation in synaptic exocytosis.

Wang S, Choi UB, Gong J, Yang X, Li Y, Wang AL, Yang X, Brunger AT, Ma C.

EMBO J. 2017 Mar 15;36(6):816-829. doi: 10.15252/embj.201695775. Epub 2017 Jan 30.

8.

Distinct Functions of Syntaxin-1 in Neuronal Maintenance, Synaptic Vesicle Docking, and Fusion in Mouse Neurons.

Vardar G, Chang S, Arancillo M, Wu YJ, Trimbuch T, Rosenmund C.

J Neurosci. 2016 Jul 27;36(30):7911-24. doi: 10.1523/JNEUROSCI.1314-16.2016.

9.

Munc13 mediates the transition from the closed syntaxin-Munc18 complex to the SNARE complex.

Ma C, Li W, Xu Y, Rizo J.

Nat Struct Mol Biol. 2011 May;18(5):542-9. doi: 10.1038/nsmb.2047. Epub 2011 Apr 17.

10.

S-nitrosylation of syntaxin 1 at Cys(145) is a regulatory switch controlling Munc18-1 binding.

Palmer ZJ, Duncan RR, Johnson JR, Lian LY, Mello LV, Booth D, Barclay JW, Graham ME, Burgoyne RD, Prior IA, Morgan A.

Biochem J. 2008 Aug 1;413(3):479-91. doi: 10.1042/BJ20080069.

PMID:
18452404
11.

SNAREpin assembly by Munc18-1 requires previous vesicle docking by synaptotagmin 1.

Parisotto D, Malsam J, Scheutzow A, Krause JM, Söllner TH.

J Biol Chem. 2012 Sep 7;287(37):31041-9. doi: 10.1074/jbc.M112.386805. Epub 2012 Jul 18.

12.

Extension of Helix 12 in Munc18-1 Induces Vesicle Priming.

Munch AS, Kedar GH, van Weering JR, Vazquez-Sanchez S, He E, André T, Braun T, Söllner TH, Verhage M, Sørensen JB.

J Neurosci. 2016 Jun 29;36(26):6881-91. doi: 10.1523/JNEUROSCI.0007-16.2016.

13.

Syntaxin1a variants lacking an N-peptide or bearing the LE mutation bind to Munc18a in a closed conformation.

Colbert KN, Hattendorf DA, Weiss TM, Burkhardt P, Fasshauer D, Weis WI.

Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12637-42. doi: 10.1073/pnas.1303753110. Epub 2013 Jul 15.

14.

SNARE bundle and syntaxin N-peptide constitute a minimal complement for Munc18-1 activation of membrane fusion.

Shen J, Rathore SS, Khandan L, Rothman JE.

J Cell Biol. 2010 Jul 12;190(1):55-63. doi: 10.1083/jcb.201003148. Epub 2010 Jul 5.

15.

Munc18-1 and the Syntaxin-1 N Terminus Regulate Open-Closed States in a t-SNARE Complex.

Dawidowski D, Cafiso DS.

Structure. 2016 Mar 1;24(3):392-400. doi: 10.1016/j.str.2016.01.005. Epub 2016 Feb 11.

16.

Allosteric control of syntaxin 1a by Munc18-1: characterization of the open and closed conformations of syntaxin.

Dawidowski D, Cafiso DS.

Biophys J. 2013 Apr 2;104(7):1585-94. doi: 10.1016/j.bpj.2013.02.004.

17.

Structural determinants of synaptobrevin 2 function in synaptic vesicle fusion.

Deák F, Shin OH, Kavalali ET, Südhof TC.

J Neurosci. 2006 Jun 21;26(25):6668-76.

18.

Munc18-dependent regulation of synaptic vesicle exocytosis by syntaxin-1A in hippocampal neurons.

Mitchell SJ, Ryan TA.

Neuropharmacology. 2005 Mar;48(3):372-80. Epub 2005 Jan 25.

PMID:
15721169
19.

Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation.

Hu SH, Christie MP, Saez NJ, Latham CF, Jarrott R, Lua LH, Collins BM, Martin JL.

Proc Natl Acad Sci U S A. 2011 Jan 18;108(3):1040-5. doi: 10.1073/pnas.0914906108. Epub 2010 Dec 30.

20.

Munc18-1 binds directly to the neuronal SNARE complex.

Dulubova I, Khvotchev M, Liu S, Huryeva I, Südhof TC, Rizo J.

Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2697-702. Epub 2007 Feb 14.

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