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Items: 1 to 20 of 717

1.

Sensitization to the lysosomal cell death pathway by oncogene-induced down-regulation of lysosome-associated membrane proteins 1 and 2.

Fehrenbacher N, Bastholm L, Kirkegaard-Sørensen T, Rafn B, Bøttzauw T, Nielsen C, Weber E, Shirasawa S, Kallunki T, Jäättelä M.

Cancer Res. 2008 Aug 15;68(16):6623-33. doi: 10.1158/0008-5472.CAN-08-0463.

2.

Sensitization to the lysosomal cell death pathway upon immortalization and transformation.

Fehrenbacher N, Gyrd-Hansen M, Poulsen B, Felbor U, Kallunki T, Boes M, Weber E, Leist M, Jäättelä M.

Cancer Res. 2004 Aug 1;64(15):5301-10.

3.

Effective tumor cell death by sigma-2 receptor ligand siramesine involves lysosomal leakage and oxidative stress.

Ostenfeld MS, Fehrenbacher N, Høyer-Hansen M, Thomsen C, Farkas T, Jäättelä M.

Cancer Res. 2005 Oct 1;65(19):8975-83.

4.
5.

Involvement of Ras/Raf-1/ERK actions in the magnolol-induced upregulation of p21 and cell-cycle arrest in colon cancer cells.

Hsu YF, Lee TS, Lin SY, Hsu SP, Juan SH, Hsu YH, Zhong WB, Lee WS.

Mol Carcinog. 2007 Apr;46(4):275-83.

PMID:
17295239
6.

Gene expression profiling by DNA microarray analysis in mouse embryonic fibroblasts transformed by rasV12 mutated protein and the E1A oncogene.

Vasseur S, Malicet C, Calvo EL, Labrie C, Berthezene P, Dagorn JC, Iovanna JL.

Mol Cancer. 2003 Mar 19;2:19.

7.

Glucose regulates protein catabolism in ras-transformed fibroblasts through a lysosomal-dependent proteolytic pathway.

Tournu C, Obled A, Roux MP, Ferrara M, Omura S, Béchet DM.

Biochem J. 2001 Jul 1;357(Pt 1):255-61.

8.

Anticancer drugs up-regulate HspBP1 and thereby antagonize the prosurvival function of Hsp70 in tumor cells.

Tanimura S, Hirano AI, Hashizume J, Yasunaga M, Kawabata T, Ozaki K, Kohno M.

J Biol Chem. 2007 Dec 7;282(49):35430-9. Epub 2007 Sep 12.

11.

Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy.

Eskelinen EL.

Mol Aspects Med. 2006 Oct-Dec;27(5-6):495-502. Epub 2006 Sep 14. Review.

PMID:
16973206
12.
13.

Cathepsin E deficiency induces a novel form of lysosomal storage disorder showing the accumulation of lysosomal membrane sialoglycoproteins and the elevation of lysosomal pH in macrophages.

Yanagawa M, Tsukuba T, Nishioku T, Okamoto Y, Okamoto K, Takii R, Terada Y, Nakayama KI, Kadowaki T, Yamamoto K.

J Biol Chem. 2007 Jan 19;282(3):1851-62. Epub 2006 Nov 9.

14.

Vincristine induces dramatic lysosomal changes and sensitizes cancer cells to lysosome-destabilizing siramesine.

Groth-Pedersen L, Ostenfeld MS, Høyer-Hansen M, Nylandsted J, Jäättelä M.

Cancer Res. 2007 Mar 1;67(5):2217-25.

15.

Akt induces apoptosis in neuroblastoma cells expressing a C98X vasopressin mutant following autophagy suppression.

Castino R, Thepparit C, Bellio N, Murphy D, Isidoro C.

J Neuroendocrinol. 2008 Oct;20(10):1165-75. doi: 10.1111/j.1365-2826.2008.01769.x. Epub 2008 Jul 30.

PMID:
18673414
16.

Expression of kinase suppressor of Ras1 enhances cisplatin-induced extracellular signal-regulated kinase activation and cisplatin sensitivity.

Kim M, Yan Y, Kortum RL, Stoeger SM, Sgagias MK, Lee K, Lewis RE, Cowan KH.

Cancer Res. 2005 May 15;65(10):3986-92.

17.

Resistance to mitogen-activated protein kinase kinase (MEK) inhibitors correlates with up-regulation of the MEK/extracellular signal-regulated kinase pathway in hepatocellular carcinoma cells.

Yip-Schneider MT, Klein PJ, Wentz SC, Zeni A, Menze A, Schmidt CM.

J Pharmacol Exp Ther. 2009 Jun;329(3):1063-70. doi: 10.1124/jpet.108.147306. Epub 2009 Mar 3.

18.

K-ras Asp12 mutant neither interacts with Raf, nor signals through Erk and is less tumorigenic than K-ras Val12.

Céspedes MV, Sancho FJ, Guerrero S, Parreño M, Casanova I, Pavón MA, Marcuello E, Trias M, Cascante M, Capellà G, Mangues R.

Carcinogenesis. 2006 Nov;27(11):2190-200. Epub 2006 May 5.

PMID:
16679305
19.

Membrane association of cathepsin B can be induced by transfection of human breast epithelial cells with c-Ha-ras oncogene.

Sloane BF, Moin K, Sameni M, Tait LR, Rozhin J, Ziegler G.

J Cell Sci. 1994 Feb;107 ( Pt 2):373-84.

20.

Loss of transgelin in breast and colon tumors and in RIE-1 cells by Ras deregulation of gene expression through Raf-independent pathways.

Shields JM, Rogers-Graham K, Der CJ.

J Biol Chem. 2002 Mar 22;277(12):9790-9. Epub 2001 Dec 28.

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