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Items: 1 to 20 of 75

1.

Ribosyl geometry in the transition state of Streptococcus pneumoniae methylthioadenosine nucleosidase from the 3'-(2)H kinetic isotope effect.

Luo M, Schramm VL.

J Am Chem Soc. 2008 Sep 3;130(35):11617-9. doi: 10.1021/ja804578m. Epub 2008 Aug 12.

PMID:
18693725
2.

Transition-state analysis of S. pneumoniae 5'-methylthioadenosine nucleosidase.

Singh V, Schramm VL.

J Am Chem Soc. 2007 Mar 14;129(10):2783-95. Epub 2007 Feb 14.

3.

Transition-state structure of human 5'-methylthioadenosine phosphorylase.

Singh V, Schramm VL.

J Am Chem Soc. 2006 Nov 15;128(45):14691-6.

4.

Remote mutations alter transition-state structure of human purine nucleoside phosphorylase.

Luo M, Li L, Schramm VL.

Biochemistry. 2008 Feb 26;47(8):2565-76. doi: 10.1021/bi702133x.

PMID:
18281957
5.

Transition State Structure and Inhibition of Rv0091, a 5'-Deoxyadenosine/5'-methylthioadenosine Nucleosidase from Mycobacterium tuberculosis.

Namanja-Magliano HA, Stratton CF, Schramm VL.

ACS Chem Biol. 2016 Jun 17;11(6):1669-76. doi: 10.1021/acschembio.6b00144. Epub 2016 Apr 8.

6.
7.

Crystal structure of 5'-methylthioadenosine nucleosidase from Arabidopsis thaliana at 1.5-A resolution.

Park EY, Oh SI, Nam MJ, Shin JS, Kim KN, Song HK.

Proteins. 2006 Nov 1;65(2):519-23. No abstract available.

PMID:
16909418
8.

Transition state analysis for human and Plasmodium falciparum purine nucleoside phosphorylases.

Lewandowicz A, Schramm VL.

Biochemistry. 2004 Feb 17;43(6):1458-68.

PMID:
14769022
9.
10.
11.

Transition State Analogue Inhibitors of 5'-Deoxyadenosine/5'-Methylthioadenosine Nucleosidase from Mycobacterium tuberculosis.

Namanja-Magliano HA, Evans GB, Harijan RK, Tyler PC, Schramm VL.

Biochemistry. 2017 Sep 26;56(38):5090-5098. doi: 10.1021/acs.biochem.7b00576. Epub 2017 Sep 7.

PMID:
28836767
12.

Over-the-barrier transition state analogues and crystal structure with Mycobacterium tuberculosis purine nucleoside phosphorylase.

Lewandowicz A, Shi W, Evans GB, Tyler PC, Furneaux RH, Basso LA, Santos DS, Almo SC, Schramm VL.

Biochemistry. 2003 May 27;42(20):6057-66.

PMID:
12755607
13.

Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases.

Evans GB, Furneaux RH, Greatrex B, Murkin AS, Schramm VL, Tyler PC.

J Med Chem. 2008 Feb 28;51(4):948-56. doi: 10.1021/jm701265n. Epub 2008 Feb 6.

PMID:
18251493
14.

Molecular determinants of substrate specificity in plant 5'-methylthioadenosine nucleosidases.

Siu KK, Lee JE, Sufrin JR, Moffatt BA, McMillan M, Cornell KA, Isom C, Howell PL.

J Mol Biol. 2008 Apr 18;378(1):112-28. doi: 10.1016/j.jmb.2008.01.088. Epub 2008 Feb 8.

15.

Transition-state interactions revealed in purine nucleoside phosphorylase by binding isotope effects.

Murkin AS, Tyler PC, Schramm VL.

J Am Chem Soc. 2008 Feb 20;130(7):2166-7. doi: 10.1021/ja7104398. Epub 2008 Jan 30. No abstract available.

PMID:
18229929
16.

Transition state structure of purine nucleoside phosphorylase and principles of atomic motion in enzymatic catalysis.

Fedorov A, Shi W, Kicska G, Fedorov E, Tyler PC, Furneaux RH, Hanson JC, Gainsford GJ, Larese JZ, Schramm VL, Almo SC.

Biochemistry. 2001 Jan 30;40(4):853-60.

PMID:
11170405
17.

Structural comparison of MTA phosphorylase and MTA/AdoHcy nucleosidase explains substrate preferences and identifies regions exploitable for inhibitor design.

Lee JE, Settembre EC, Cornell KA, Riscoe MK, Sufrin JR, Ealick SE, Howell PL.

Biochemistry. 2004 May 11;43(18):5159-69.

PMID:
15122881
18.

Structural enzymology of Helicobacter pylori methylthioadenosine nucleosidase in the futalosine pathway.

Kim RQ, Offen WA, Davies GJ, Stubbs KA.

Acta Crystallogr D Biol Crystallogr. 2014 Jan;70(Pt 1):177-85. doi: 10.1107/S1399004713026655. Epub 2013 Dec 31.

PMID:
24419390
19.
20.

Picomolar inhibitors as transition-state probes of 5'-methylthioadenosine nucleosidases.

Gutierrez JA, Luo M, Singh V, Li L, Brown RL, Norris GE, Evans GB, Furneaux RH, Tyler PC, Painter GF, Lenz DH, Schramm VL.

ACS Chem Biol. 2007 Nov 20;2(11):725-34.

PMID:
18030989

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