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Fibroblast growth factor 21 corrects obesity in mice.

Coskun T, Bina HA, Schneider MA, Dunbar JD, Hu CC, Chen Y, Moller DE, Kharitonenkov A.

Endocrinology. 2008 Dec;149(12):6018-27. doi: 10.1210/en.2008-0816. Epub 2008 Aug 7.


Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice.

Xu J, Lloyd DJ, Hale C, Stanislaus S, Chen M, Sivits G, Vonderfecht S, Hecht R, Li YS, Lindberg RA, Chen JL, Jung DY, Zhang Z, Ko HJ, Kim JK, Véniant MM.

Diabetes. 2009 Jan;58(1):250-9. doi: 10.2337/db08-0392. Epub 2008 Oct 7.


Lack of overt FGF21 resistance in two mouse models of obesity and insulin resistance.

Hale C, Chen MM, Stanislaus S, Chinookoswong N, Hager T, Wang M, Véniant MM, Xu J.

Endocrinology. 2012 Jan;153(1):69-80. doi: 10.1210/en.2010-1262. Epub 2011 Nov 8.


Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice.

Cho AS, Jeon SM, Kim MJ, Yeo J, Seo KI, Choi MS, Lee MK.

Food Chem Toxicol. 2010 Mar;48(3):937-43. doi: 10.1016/j.fct.2010.01.003. Epub 2010 Jan 12.


Peripheral reduction of FGFR4 with antisense oligonucleotides increases metabolic rate and lowers adiposity in diet-induced obese mice.

Yu XX, Watts LM, Manchem VP, Chakravarty K, Monia BP, McCaleb ML, Bhanot S.

PLoS One. 2013 Jul 29;8(7):e66923. doi: 10.1371/journal.pone.0066923. Print 2013.


Metabolic effects of low dose angiotensin converting enzyme inhibitor in dietary obesity in the rat.

Velkoska E, Warner FJ, Cole TJ, Smith I, Morris MJ.

Nutr Metab Cardiovasc Dis. 2010 Jan;20(1):49-55. doi: 10.1016/j.numecd.2009.02.004. Epub 2009 Apr 9.


Combined effects of rosiglitazone and conjugated linoleic acid on adiposity, insulin sensitivity, and hepatic steatosis in high-fat-fed mice.

Liu LF, Purushotham A, Wendel AA, Belury MA.

Am J Physiol Gastrointest Liver Physiol. 2007 Jun;292(6):G1671-82. Epub 2007 Feb 22.


Hydrodynamic delivery of FGF21 gene alleviates obesity and fatty liver in mice fed a high-fat diet.

Gao M, Ma Y, Cui R, Liu D.

J Control Release. 2014 Jul 10;185:1-11. doi: 10.1016/j.jconrel.2014.03.047. Epub 2014 Apr 18.


Eicosapentaenoic acid reduces adipocyte hypertrophy and inflammation in diet-induced obese mice in an adiposity-independent manner.

LeMieux MJ, Kalupahana NS, Scoggin S, Moustaid-Moussa N.

J Nutr. 2015 Mar;145(3):411-7. doi: 10.3945/jn.114.202952. Epub 2014 Dec 31.


Amylin improves the effect of leptin on insulin sensitivity in leptin-resistant diet-induced obese mice.

Kusakabe T, Ebihara K, Sakai T, Miyamoto L, Aotani D, Yamamoto Y, Yamamoto-Kataoka S, Aizawa-Abe M, Fujikura J, Hosoda K, Nakao K.

Am J Physiol Endocrinol Metab. 2012 Apr 15;302(8):E924-31. doi: 10.1152/ajpendo.00198.2011. Epub 2012 Jan 24.


Fibroblast growth factor 21 action in the brain increases energy expenditure and insulin sensitivity in obese rats.

Sarruf DA, Thaler JP, Morton GJ, German J, Fischer JD, Ogimoto K, Schwartz MW.

Diabetes. 2010 Jul;59(7):1817-24. doi: 10.2337/db09-1878. Epub 2010 Mar 31.


Recombinant murine fibroblast growth factor 21 ameliorates obesity-related inflammation in monosodium glutamate-induced obesity rats.

Wang WF, Li SM, Ren GP, Zheng W, Lu YJ, Yu YH, Xu WJ, Li TH, Zhou LH, Liu Y, Li DS.

Endocrine. 2015 May;49(1):119-29. doi: 10.1007/s12020-014-0433-5. Epub 2014 Oct 12.


Selective Kv1.3 channel blocker as therapeutic for obesity and insulin resistance.

Upadhyay SK, Eckel-Mahan KL, Mirbolooki MR, Tjong I, Griffey SM, Schmunk G, Koehne A, Halbout B, Iadonato S, Pedersen B, Borrelli E, Wang PH, Mukherjee J, Sassone-Corsi P, Chandy KG.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):E2239-48. doi: 10.1073/pnas.1221206110. Epub 2013 May 31.


Extensive impact of saturated fatty acids on metabolic and cardiovascular profile in rats with diet-induced obesity: a canonical analysis.

Oliveira Junior SA, Padovani CR, Rodrigues SA, Silva NR, Martinez PF, Campos DH, Okoshi MP, Okoshi K, Dal-Pai M, Cicogna AC.

Cardiovasc Diabetol. 2013 Apr 15;12:65. doi: 10.1186/1475-2840-12-65.


Dietary capsaicin reduces obesity-induced insulin resistance and hepatic steatosis in obese mice fed a high-fat diet.

Kang JH, Goto T, Han IS, Kawada T, Kim YM, Yu R.

Obesity (Silver Spring). 2010 Apr;18(4):780-7. doi: 10.1038/oby.2009.301. Epub 2009 Oct 1.


Increased responses to the actions of fibroblast growth factor 21 on energy balance and body weight in a seasonal model of adiposity.

Murphy M, Samms R, Warner A, Bolborea M, Barrett P, Fowler MJ, Brameld JM, Tsintzas K, Kharitonenkov A, Adams AC, Coskun T, Ebling FJ.

J Neuroendocrinol. 2013 Feb;25(2):180-9. doi: 10.1111/j.1365-2826.2012.02383.x.


Repetitive orogastric gavage affects the phenotype of diet-induced obese mice.

de Meijer VE, Le HD, Meisel JA, Puder M.

Physiol Behav. 2010 Jun 16;100(4):387-93. doi: 10.1016/j.physbeh.2010.04.001. Epub 2010 Apr 10.


Analysis of time-dependent adaptations in whole-body energy balance in obesity induced by high-fat diet in rats.

So M, Gaidhu MP, Maghdoori B, Ceddia RB.

Lipids Health Dis. 2011 Jun 16;10:99. doi: 10.1186/1476-511X-10-99.


Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models--association with liver and adipose tissue effects.

Xu J, Stanislaus S, Chinookoswong N, Lau YY, Hager T, Patel J, Ge H, Weiszmann J, Lu SC, Graham M, Busby J, Hecht R, Li YS, Li Y, Lindberg R, Véniant MM.

Am J Physiol Endocrinol Metab. 2009 Nov;297(5):E1105-14. doi: 10.1152/ajpendo.00348.2009. Epub 2009 Aug 25.


Effects of a selective melanin-concentrating hormone 1 receptor antagonist on food intake and energy homeostasis in diet-induced obese mice.

Kowalski TJ, Spar BD, Weig B, Farley C, Cook J, Ghibaudi L, Fried S, O'Neill K, Del Vecchio RA, McBriar M, Guzik H, Clader J, Hawes BE, Hwa J.

Eur J Pharmacol. 2006 Mar 27;535(1-3):182-91. Epub 2006 Mar 13.


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