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Items: 1 to 20 of 446

1.

Metal compounds for the treatment of parasitic diseases.

Fricker SP, Mosi RM, Cameron BR, Baird I, Zhu Y, Anastassov V, Cox J, Doyle PS, Hansell E, Lau G, Langille J, Olsen M, Qin L, Skerlj R, Wong RS, Santucci Z, McKerrow JH.

J Inorg Biochem. 2008 Oct;102(10):1839-45. doi: 10.1016/j.jinorgbio.2008.05.010. Epub 2008 Jun 4. Erratum in: J Inorg Biochem. 2009 May;103(5):869.

PMID:
18684510
2.

Synthesis and characterization of a pyridine-2-thiol N-oxide gold(I) complex with potent antiproliferative effect against Trypanosoma cruzi and Leishmania sp. insight into its mechanism of action.

Vieites M, Smircich P, Guggeri L, Marchán E, Gómez-Barrio A, Navarro M, Garat B, Gambino D.

J Inorg Biochem. 2009 Oct;103(10):1300-6. doi: 10.1016/j.jinorgbio.2009.02.011. Epub 2009 Mar 17.

PMID:
19361864
3.

Altered expression of cruzipain and a cathepsin B-like target in a Trypanosoma cruzi cell line displaying resistance to synthetic inhibitors of cysteine-proteinases.

Yong V, Schmitz V, Vannier-Santos MA, de Lima AP, Lalmanach G, Juliano L, Gauthier F, Scharfstein J.

Mol Biochem Parasitol. 2000 Jun;109(1):47-59.

PMID:
10924756
4.

Leishmania major: molecular modeling of cysteine proteases and prediction of new nonpeptide inhibitors.

Selzer PM, Chen X, Chan VJ, Cheng M, Kenyon GL, Kuntz ID, Sakanari JA, Cohen FE, McKerrow JH.

Exp Parasitol. 1997 Nov;87(3):212-21.

PMID:
9371086
5.

Use of cysteine-reactive small molecules in drug discovery for trypanosomal disease.

Nicoll-Griffith DA.

Expert Opin Drug Discov. 2012 Apr;7(4):353-66. doi: 10.1517/17460441.2012.668520. Epub 2012 Mar 6. Review.

PMID:
22458506
6.

Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain.

Du X, Guo C, Hansell E, Doyle PS, Caffrey CR, Holler TP, McKerrow JH, Cohen FE.

J Med Chem. 2002 Jun 20;45(13):2695-707.

PMID:
12061873
7.

Structure-based design, synthesis and evaluation of conformationally constrained cysteine protease inhibitors.

Scheidt KA, Roush WR, McKerrow JH, Selzer PM, Hansell E, Rosenthal PJ.

Bioorg Med Chem. 1998 Dec;6(12):2477-94.

PMID:
9925304
8.

Rhenium inhibitors of cathepsin B (ReO(SYS)X (where Y = S, py; X = Cl, Br, SPhOMe-p)): Synthesis and mechanism of inhibition.

Mosi R, Baird IR, Cox J, Anastassov V, Cameron B, Skerlj RT, Fricker SP.

J Med Chem. 2006 Aug 24;49(17):5262-72.

PMID:
16913715
9.

Chalcone, acyl hydrazide, and related amides kill cultured Trypanosoma brucei brucei.

Troeberg L, Chen X, Flaherty TM, Morty RE, Cheng M, Hua H, Springer C, McKerrow JH, Kenyon GL, Lonsdale-Eccles JD, Coetzer TH, Cohen FE.

Mol Med. 2000 Aug;6(8):660-9.

10.

Development of alpha-keto-based inhibitors of cruzain, a cysteine protease implicated in Chagas disease.

Choe Y, Brinen LS, Price MS, Engel JC, Lange M, Grisostomi C, Weston SG, Pallai PV, Cheng H, Hardy LW, Hartsough DS, McMakin M, Tilton RF, Baldino CM, Craik CS.

Bioorg Med Chem. 2005 Mar 15;13(6):2141-56.

PMID:
15727867
11.

Inhibition of the cathepsin cysteine proteases B and K by square-planar cycloaurated gold(III) compounds and investigation of their anti-cancer activity.

Zhu Y, Cameron BR, Mosi R, Anastassov V, Cox J, Qin L, Santucci Z, Metz M, Skerlj RT, Fricker SP.

J Inorg Biochem. 2011 May;105(5):754-62. doi: 10.1016/j.jinorgbio.2011.01.012. Epub 2011 Jan 26.

PMID:
21481817
12.

Aryl ureas represent a new class of anti-trypanosomal agents.

Du X, Hansell E, Engel JC, Caffrey CR, Cohen FE, McKerrow JH.

Chem Biol. 2000 Sep;7(9):733-42.

13.

Phenyl substitution of furamidine markedly potentiates its anti-parasitic activity against Trypanosoma cruzi and Leishmania amazonensis.

De Souza EM, Lansiaux A, Bailly C, Wilson WD, Hu Q, Boykin DW, Batista MM, Araújo-Jorge TC, Soeiro MN.

Biochem Pharmacol. 2004 Aug 15;68(4):593-600.

PMID:
15276066
14.

Upregulation of the secretory pathway in cysteine protease inhibitor-resistant Trypanosoma cruzi.

Engel JC, Torres C, Hsieh I, Doyle PS, McKerrow JH.

J Cell Sci. 2000 Apr;113 ( Pt 8):1345-54. Erratum in: J Cell Sci 2000 Jul;113(Pt 14):2638. Garcia CT [corrected to Torres C].

15.

Cysteine protease inhibitors as chemotherapy for parasitic infections.

McKerrow JH, Engel JC, Caffrey CR.

Bioorg Med Chem. 1999 Apr;7(4):639-44. Review.

PMID:
10353643
16.

Synthesis of a sugar-based thiosemicarbazone series and structure-activity relationship versus the parasite cysteine proteases rhodesain, cruzain, and Schistosoma mansoni cathepsin B1.

Fonseca NC, da Cruz LF, da Silva Villela F, do Nascimento Pereira GA, de Siqueira-Neto JL, Kellar D, Suzuki BM, Ray D, de Souza TB, Alves RJ, Sales Júnior PA, Romanha AJ, Murta SM, McKerrow JH, Caffrey CR, de Oliveira RB, Ferreira RS.

Antimicrob Agents Chemother. 2015 May;59(5):2666-77. doi: 10.1128/AAC.04601-14. Epub 2015 Feb 23.

17.

Cysteine protease isoforms from Trypanosoma cruzi, cruzipain 2 and cruzain, present different substrate preference and susceptibility to inhibitors.

Lima AP, dos Reis FC, Serveau C, Lalmanach G, Juliano L, Ménard R, Vernet T, Thomas DY, Storer AC, Scharfstein J.

Mol Biochem Parasitol. 2001 Apr 25;114(1):41-52.

PMID:
11356512
18.

Proteinases of Trypanosoma cruzi: patential targets for the chemotherapy of Changas desease.

Cazzulo JJ.

Curr Top Med Chem. 2002 Nov;2(11):1261-71. Review.

PMID:
12171584
19.

The major cysteine proteinase of Trypanosoma cruzi: a valid target for chemotherapy of Chagas disease.

Jose Cazzulo J, Stoka V, Turk V.

Curr Pharm Des. 2001 Aug;7(12):1143-56. Review.

PMID:
11472258
20.

Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi.

Greenbaum DC, Mackey Z, Hansell E, Doyle P, Gut J, Caffrey CR, Lehrman J, Rosenthal PJ, McKerrow JH, Chibale K.

J Med Chem. 2004 Jun 3;47(12):3212-9.

PMID:
15163200

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