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The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint.

Bassermann F, Frescas D, Guardavaccaro D, Busino L, Peschiaroli A, Pagano M.

Cell. 2008 Jul 25;134(2):256-67. doi: 10.1016/j.cell.2008.05.043.


Cdc14B and APC/C tackle DNA damage.

De Wulf P, Visintin R.

Cell. 2008 Jul 25;134(2):210-2. doi: 10.1016/j.cell.2008.07.004.


Polo-like kinase-1 controls Aurora A destruction by activating APC/C-Cdh1.

van Leuken R, Clijsters L, van Zon W, Lim D, Yao X, Wolthuis RM, Yaffe MB, Medema RH, van Vugt MA.

PLoS One. 2009;4(4):e5282. doi: 10.1371/journal.pone.0005282. Epub 2009 Apr 23.


Polo-like kinase 1 activated by the hepatitis B virus X protein attenuates both the DNA damage checkpoint and DNA repair resulting in partial polyploidy.

Studach L, Wang WH, Weber G, Tang J, Hullinger RL, Malbrue R, Liu X, Andrisani O.

J Biol Chem. 2010 Sep 24;285(39):30282-93. doi: 10.1074/jbc.M109.093963. Epub 2010 Jul 12.


USP7 counteracts SCFbetaTrCP- but not APCCdh1-mediated proteolysis of Claspin.

Faustrup H, Bekker-Jensen S, Bartek J, Lukas J, Mailand N.

J Cell Biol. 2009 Jan 12;184(1):13-9. doi: 10.1083/jcb.200807137. Epub 2009 Jan 5.


Mitotic DNA damage response: Polo-like kinase-1 is dephosphorylated through ATM-Chk1 pathway.

Lee HJ, Hwang HI, Jang YJ.

Cell Cycle. 2010 Jun 15;9(12):2389-98. Epub 2010 Jun 15.


Activation of Cdh1-dependent APC is required for G1 cell cycle arrest and DNA damage-induced G2 checkpoint in vertebrate cells.

Sudo T, Ota Y, Kotani S, Nakao M, Takami Y, Takeda S, Saya H.

EMBO J. 2001 Nov 15;20(22):6499-508.


p53- and p21-dependent premature APC/C-Cdh1 activation in G2 is part of the long-term response to genotoxic stress.

Wiebusch L, Hagemeier C.

Oncogene. 2010 Jun 17;29(24):3477-89. doi: 10.1038/onc.2010.99. Epub 2010 Apr 12.


The ubiquitin ligase APC(Cdh1) is required to maintain genome integrity in primary human cells.

Engelbert D, Schnerch D, Baumgarten A, Wäsch R.

Oncogene. 2008 Feb 7;27(7):907-17. Epub 2007 Aug 13.


Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery.

Mamely I, van Vugt MA, Smits VA, Semple JI, Lemmens B, Perrakis A, Medema RH, Freire R.

Curr Biol. 2006 Oct 10;16(19):1950-5. Epub 2006 Aug 24.


Functional analysis of APC-Cdh1.

Sudo T, Ueno NT, Saya H.

Methods Mol Biol. 2004;281:189-98.


Phosphorylation of Plk1 at S137 and T210 is inhibited in response to DNA damage.

Tsvetkov L, Stern DF.

Cell Cycle. 2005 Jan;4(1):166-71. Epub 2005 Jan 5.


Human papillomavirus 16 E7 oncoprotein attenuates DNA damage checkpoint control by increasing the proteolytic turnover of claspin.

Spardy N, Covella K, Cha E, Hoskins EE, Wells SI, Duensing A, Duensing S.

Cancer Res. 2009 Sep 1;69(17):7022-9. doi: 10.1158/0008-5472.CAN-09-0925. Epub 2009 Aug 25.


Expression of constitutively active CDK1 stabilizes APC-Cdh1 substrates and potentiates premature spindle assembly and checkpoint function in G1 cells.

Ma Y, Yuan X, Wyatt WR, Pomerening JR.

PLoS One. 2012;7(3):e33835. doi: 10.1371/journal.pone.0033835. Epub 2012 Mar 29.


Nuclear translocation of Cyclin B1 marks the restriction point for terminal cell cycle exit in G2 phase.

Müllers E, Silva Cascales H, Jaiswal H, Saurin AT, Lindqvist A.

Cell Cycle. 2014;13(17):2733-43. doi: 10.4161/15384101.2015.945831.


A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint.

van Vugt MA, Gardino AK, Linding R, Ostheimer GJ, Reinhardt HC, Ong SE, Tan CS, Miao H, Keezer SM, Li J, Pawson T, Lewis TA, Carr SA, Smerdon SJ, Brummelkamp TR, Yaffe MB.

PLoS Biol. 2010 Jan 26;8(1):e1000287. doi: 10.1371/journal.pbio.1000287.


Controlling the response to DNA damage by the APC/C-Cdh1.

de Boer HR, Guerrero Llobet S, van Vugt MA.

Cell Mol Life Sci. 2016 Mar;73(5):949-60. doi: 10.1007/s00018-015-2096-7. Epub 2015 Dec 9. Review. Erratum in: Cell Mol Life Sci. 2016 Aug;73(15):2985-98.


APC/C(Cdh1) targets brain-specific kinase 2 (BRSK2) for degradation via the ubiquitin-proteasome pathway.

Li R, Wan B, Zhou J, Wang Y, Luo T, Gu X, Chen F, Yu L.

PLoS One. 2012;7(9):e45932. doi: 10.1371/journal.pone.0045932. Epub 2012 Sep 21.

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