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Items: 1 to 20 of 167


Assembly of a Fab1 phosphoinositide kinase signaling complex requires the Fig4 phosphoinositide phosphatase.

Botelho RJ, Efe JA, Teis D, Emr SD.

Mol Biol Cell. 2008 Oct;19(10):4273-86. doi: 10.1091/mbc.E08-04-0405. Epub 2008 Jul 23.


Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member.

Gary JD, Sato TK, Stefan CJ, Bonangelino CJ, Weisman LS, Emr SD.

Mol Biol Cell. 2002 Apr;13(4):1238-51.


Vac14 protein multimerization is a prerequisite step for Fab1 protein complex assembly and function.

Alghamdi TA, Ho CY, Mrakovic A, Taylor D, Mao D, Botelho RJ.

J Biol Chem. 2013 Mar 29;288(13):9363-72. doi: 10.1074/jbc.M113.453712. Epub 2013 Feb 6.


Vac14 controls PtdIns(3,5)P(2) synthesis and Fab1-dependent protein trafficking to the multivesicular body.

Dove SK, McEwen RK, Mayes A, Hughes DC, Beggs JD, Michell RH.

Curr Biol. 2002 Jun 4;12(11):885-93.


Fab1p is essential for PtdIns(3)P 5-kinase activity and the maintenance of vacuolar size and membrane homeostasis.

Gary JD, Wurmser AE, Bonangelino CJ, Weisman LS, Emr SD.

J Cell Biol. 1998 Oct 5;143(1):65-79.


Phosphoinositide signaling: vac to the future in fab1 kinase regulation.

DeWald DB.

Curr Biol. 2002 Jul 23;12(14):R491-2. Review.


Osmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p.

Bonangelino CJ, Nau JJ, Duex JE, Brinkman M, Wurmser AE, Gary JD, Emr SD, Weisman LS.

J Cell Biol. 2002 Mar 18;156(6):1015-28. Epub 2002 Mar 11.


A protein complex that regulates PtdIns(3,5)P2 levels.

Michell RH, Dove SK.

EMBO J. 2009 Jan 21;28(2):86-7. doi: 10.1038/emboj.2008.270.


Inactivation of the phosphoinositide phosphatases Sac1p and Inp54p leads to accumulation of phosphatidylinositol 4,5-bisphosphate on vacuole membranes and vacuolar fusion defects.

Wiradjaja F, Ooms LM, Tahirovic S, Kuhne E, Devenish RJ, Munn AL, Piper RC, Mayinger P, Mitchell CA.

J Biol Chem. 2007 Jun 1;282(22):16295-307. Epub 2007 Mar 28.


VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse.

Jin N, Chow CY, Liu L, Zolov SN, Bronson R, Davisson M, Petersen JL, Zhang Y, Park S, Duex JE, Goldowitz D, Meisler MH, Weisman LS.

EMBO J. 2008 Dec 17;27(24):3221-34. doi: 10.1038/emboj.2008.248. Epub 2008 Nov 27.


Phosphatidylinositol-3,5-bisphosphate: no longer the poor PIP2.

Ho CY, Alghamdi TA, Botelho RJ.

Traffic. 2012 Jan;13(1):1-8. doi: 10.1111/j.1600-0854.2011.01246.x. Epub 2011 Jul 27. Review.


Regulation of intracellular phosphatidylinositol-4-phosphate by the Sac1 lipid phosphatase.

Tahirovic S, Schorr M, Mayinger P.

Traffic. 2005 Feb;6(2):116-30.


Complementation analysis in PtdInsP kinase-deficient yeast mutants demonstrates that Schizosaccharomyces pombe and murine Fab1p homologues are phosphatidylinositol 3-phosphate 5-kinases.

McEwen RK, Dove SK, Cooke FT, Painter GF, Holmes AB, Shisheva A, Ohya Y, Parker PJ, Michell RH.

J Biol Chem. 1999 Nov 26;274(48):33905-12.


Novel PI(4)P 5-kinase homologue, Fab1p, essential for normal vacuole function and morphology in yeast.

Yamamoto A, DeWald DB, Boronenkov IV, Anderson RA, Emr SD, Koshland D.

Mol Biol Cell. 1995 May;6(5):525-39.


Characterization of a phosphatidylinositol-specific phosphoinositide 3-kinase from mammalian cells.

Stephens L, Cooke FT, Walters R, Jackson T, Volinia S, Gout I, Waterfield MD, Hawkins PT.

Curr Biol. 1994 Mar 1;4(3):203-14.

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