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Bcl-x(L) and Myeloid cell leukaemia-1 contribute to apoptosis resistance of colorectal cancer cells.

Schulze-Bergkamen H, Ehrenberg R, Hickmann L, Vick B, Urbanik T, Schimanski CC, Berger MR, Schad A, Weber A, Heeger S, Galle PR, Moehler M.

World J Gastroenterol. 2008 Jun 28;14(24):3829-40.


TRAIL-induced apoptosis of hepatocellular carcinoma cells is augmented by targeted therapies.

Koehler BC, Urbanik T, Vick B, Boger RJ, Heeger S, Galle PR, Schuchmann M, Schulze-Bergkamen H.

World J Gastroenterol. 2009 Dec 21;15(47):5924-35.


The Bcl-2/xL inhibitor ABT-263 increases the stability of Mcl-1 mRNA and protein in hepatocellular carcinoma cells.

Wang B, Ni Z, Dai X, Qin L, Li X, Xu L, Lian J, He F.

Mol Cancer. 2014 Apr 30;13:98. doi: 10.1186/1476-4598-13-98.


Mcl-1 regulates survival and sensitivity to diverse apoptotic stimuli in human non-small cell lung cancer cells.

Song L, Coppola D, Livingston S, Cress D, Haura EB.

Cancer Biol Ther. 2005 Mar;4(3):267-76. Epub 2005 Mar 20.


Mcl-1 as a buffer for proapoptotic Bcl-2 family members during TRAIL-induced apoptosis: a mechanistic basis for sorafenib (Bay 43-9006)-induced TRAIL sensitization.

Meng XW, Lee SH, Dai H, Loegering D, Yu C, Flatten K, Schneider P, Dai NT, Kumar SK, Smith BD, Karp JE, Adjei AA, Kaufmann SH.

J Biol Chem. 2007 Oct 12;282(41):29831-46. Epub 2007 Aug 13.


Suppression of Mcl-1 via RNA interference sensitizes human hepatocellular carcinoma cells towards apoptosis induction.

Schulze-Bergkamen H, Fleischer B, Schuchmann M, Weber A, Weinmann A, Krammer PH, Galle PR.

BMC Cancer. 2006 Oct 2;6:232.


Sorafenib inhibits STAT3 activation to enhance TRAIL-mediated apoptosis in human pancreatic cancer cells.

Huang S, Sinicrope FA.

Mol Cancer Ther. 2010 Mar;9(3):742-50. doi: 10.1158/1535-7163.MCT-09-1004. Epub 2010 Mar 2.


Functional and biological analysis of Bcl-xL expression in human osteosarcoma.

Wang ZX, Yang JS, Pan X, Wang JR, Li J, Yin YM, De W.

Bone. 2010 Aug;47(2):445-54. doi: 10.1016/j.bone.2010.05.027. Epub 2010 May 23.


Beyond cell death - antiapoptotic Bcl-2 proteins regulate migration and invasion of colorectal cancer cells in vitro.

Koehler BC, Scherr AL, Lorenz S, Urbanik T, Kautz N, Elssner C, Welte S, Bermejo JL, Jäger D, Schulze-Bergkamen H.

PLoS One. 2013 Oct 3;8(10):e76446. doi: 10.1371/journal.pone.0076446. eCollection 2013.


Bcl-XL and MCL-1 constitute pertinent targets in ovarian carcinoma and their concomitant inhibition is sufficient to induce apoptosis.

Brotin E, Meryet-Figuière M, Simonin K, Duval RE, Villedieu M, Leroy-Dudal J, Saison-Behmoaras E, Gauduchon P, Denoyelle C, Poulain L.

Int J Cancer. 2010 Feb 15;126(4):885-95. doi: 10.1002/ijc.24787.


[STI571 induces apoptosis of K562 cells through down-regulation of anti-apoptotic protein Mcl-1 and Bcl-xl expression].

Zhang BZ, Ren HY.

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2007 Dec;15(6):1182-5. Chinese.


Downregulation of Bcl-xL and Mcl-1 is sufficient to induce cell death in mesothelioma cells highly refractory to conventional chemotherapy.

Varin E, Denoyelle C, Brotin E, Meryet-Figuière M, Giffard F, Abeilard E, Goux D, Gauduchon P, Icard P, Poulain L.

Carcinogenesis. 2010 Jun;31(6):984-93. doi: 10.1093/carcin/bgq026. Epub 2010 Feb 8.


The downregulation of Mcl-1 via USP9X inhibition sensitizes solid tumors to Bcl-xl inhibition.

Peddaboina C, Jupiter D, Fletcher S, Yap JL, Rai A, Tobin RP, Jiang W, Rascoe P, Rogers MK, Smythe WR, Cao X.

BMC Cancer. 2012 Nov 21;12:541. doi: 10.1186/1471-2407-12-541.


Gamma-secretase inhibition attenuates oxaliplatin-induced apoptosis through increased Mcl-1 and/or Bcl-xL in human colon cancer cells.

Timme CR, Gruidl M, Yeatman TJ.

Apoptosis. 2013 Oct;18(10):1163-74. doi: 10.1007/s10495-013-0883-x.


Metformin enhances TRAIL-induced apoptosis by Mcl-1 degradation via Mule in colorectal cancer cells.

Park SH, Lee DH, Kim JL, Kim BR, Na YJ, Jo MJ, Jeong YA, Lee SY, Lee SI, Lee YY, Oh SC.

Oncotarget. 2016 Sep 13;7(37):59503-59518. doi: 10.18632/oncotarget.11147.


Silencing of prion protein sensitizes breast adriamycin-resistant carcinoma cells to TRAIL-mediated cell death.

Meslin F, Hamaï A, Gao P, Jalil A, Cahuzac N, Chouaib S, Mehrpour M.

Cancer Res. 2007 Nov 15;67(22):10910-9.


YM-155 potentiates the effect of ABT-737 in malignant human glioma cells via survivin and Mcl-1 downregulation in an EGFR-dependent context.

Jane EP, Premkumar DR, DiDomenico JD, Hu B, Cheng SY, Pollack IF.

Mol Cancer Ther. 2013 Mar;12(3):326-38. doi: 10.1158/1535-7163.MCT-12-0901. Epub 2013 Jan 16.

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