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Items: 1 to 20 of 146

1.

Developmental exposure to trichloroethylene promotes CD4+ T cell differentiation and hyperactivity in association with oxidative stress and neurobehavioral deficits in MRL+/+ mice.

Blossom SJ, Doss JC, Hennings LJ, Jernigan S, Melnyk S, James SJ.

Toxicol Appl Pharmacol. 2008 Sep 15;231(3):344-53. doi: 10.1016/j.taap.2008.05.009. Epub 2008 May 20.

PMID:
18579175
2.
4.

Chronic exposure to a trichloroethylene metabolite in autoimmune-prone MRL+/+ mice promotes immune modulation and alopecia.

Blossom SJ, Doss JC, Gilbert KM.

Toxicol Sci. 2007 Feb;95(2):401-11. Epub 2006 Oct 31.

PMID:
17077186
5.

Environmental contaminant trichloroethylene promotes autoimmune disease and inhibits T-cell apoptosis in MRL(+/+) mice.

Gilbert KM, Pumford NR, Blossom SJ.

J Immunotoxicol. 2006 Dec 1;3(4):263-7. doi: 10.1080/15476910601023578.

PMID:
18958707
6.

Immunotoxicity of trichloroethylene: a study with MRL-lpr/lpr mice.

Kaneko T, Saegusa M, Tasaka K, Sato A.

J Appl Toxicol. 2000 Nov-Dec;20(6):471-5.

PMID:
11180269
7.

CD4(+) T-cell activation and induction of autoimmune hepatitis following trichloroethylene treatment in MRL+/+ mice.

Griffin JM, Gilbert KM, Lamps LW, Pumford NR.

Toxicol Sci. 2000 Oct;57(2):345-52.

PMID:
11006364
8.

Trichloroethylene accelerates an autoimmune response by Th1 T cell activation in MRL +/+ mice.

Griffin JM, Blossom SJ, Jackson SK, Gilbert KM, Pumford NR.

Immunopharmacology. 2000 Feb;46(2):123-37.

PMID:
10647871
9.

Trichloroethylene activates CD4+ T cells: potential role in an autoimmune response.

Gilbert KM, Griffin JM, Pumford NR.

Drug Metab Rev. 1999 Nov;31(4):901-16.

PMID:
10575554
11.

Delineating liver events in trichloroethylene-induced autoimmune hepatitis.

Gilbert KM, Przybyla B, Pumford NR, Han T, Fuscoe J, Schnackenberg LK, Holland RD, Doss JC, Macmillan-Crow LA, Blossom SJ.

Chem Res Toxicol. 2009 Apr;22(4):626-32. doi: 10.1021/tx800409r.

PMID:
19254012
12.

Epigenetic alterations may regulate temporary reversal of CD4(+) T cell activation caused by trichloroethylene exposure.

Gilbert KM, Nelson AR, Cooney CA, Reisfeld B, Blossom SJ.

Toxicol Sci. 2012 May;127(1):169-78. doi: 10.1093/toxsci/kfs093. Epub 2012 Mar 9.

13.

Lifetime exposure to trichloroethylene (TCE) does not accelerate autoimmune disease in MRL +/+ mice.

Peden-Adams MM, Eudaly JG, Lee AM, Miller J, Keil DE, Gilkeson GS.

J Environ Sci Health A Tox Hazard Subst Environ Eng. 2008 Oct;43(12):1402-9. doi: 10.1080/10934520802232063.

PMID:
18780217
14.

Evidence of autoimmune-related effects of trichloroethylene exposure from studies in mice and humans.

Cooper GS, Makris SL, Nietert PJ, Jinot J.

Environ Health Perspect. 2009 May;117(5):696-702. doi: 10.1289/ehp.11782. Epub 2009 Jan 9. Review.

15.

Inhibition of CYP2E1 reverses CD4+ T-cell alterations in trichloroethylene-treated MRL+/+ mice.

Griffin JM, Gilbert KM, Pumford NR.

Toxicol Sci. 2000 Apr;54(2):384-9.

PMID:
10774820
16.

Postnatal exposure to trichloroethylene alters glutathione redox homeostasis, methylation potential, and neurotrophin expression in the mouse hippocampus.

Blossom SJ, Melnyk S, Cooney CA, Gilbert KM, James SJ.

Neurotoxicology. 2012 Dec;33(6):1518-27. doi: 10.1016/j.neuro.2012.02.017. Epub 2012 Mar 7.

17.

Chronic exposure to trichloroethylene increases DNA methylation of the Ifng promoter in CD4+ T cells.

Gilbert KM, Blossom SJ, Erickson SW, Broadfoot B, West K, Bai S, Li J, Cooney CA.

Toxicol Lett. 2016 Oct 17;260:1-7. doi: 10.1016/j.toxlet.2016.08.017. Epub 2016 Aug 21.

PMID:
27553676
18.

Environmental contaminant and disinfection by-product trichloroacetaldehyde stimulates T cells in vitro.

Gilbert KM, Whitlow AB, Pumford NR.

Int Immunopharmacol. 2004 Jan;4(1):25-36.

PMID:
14975357
19.

Metabolic changes and DNA hypomethylation in cerebellum are associated with behavioral alterations in mice exposed to trichloroethylene postnatally.

Blossom SJ, Cooney CA, Melnyk SB, Rau JL, Swearingen CJ, Wessinger WD.

Toxicol Appl Pharmacol. 2013 Jun 15;269(3):263-9. doi: 10.1016/j.taap.2013.03.025. Epub 2013 Apr 6.

20.

Effect of trichloroethylene on the exploratory and locomotor activity of rats exposed during development.

Taylor DH, Lagory KE, Zaccaro DJ, Pfohl RJ, Laurie RD.

Sci Total Environ. 1985 Dec;47:415-20.

PMID:
4089608

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