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Items: 1 to 20 of 116


Diphosphothreonine-specific interaction between an SQ/TQ cluster and an FHA domain in the Rad53-Dun1 kinase cascade.

Lee H, Yuan C, Hammet A, Mahajan A, Chen ES, Wu MR, Su MI, Heierhorst J, Tsai MD.

Mol Cell. 2008 Jun 20;30(6):767-78. doi: 10.1016/j.molcel.2008.05.013.


Use of quantitative mass spectrometric analysis to elucidate the mechanisms of phospho-priming and auto-activation of the checkpoint kinase Rad53 in vivo.

Chen ES, Hoch NC, Wang SC, Pellicioli A, Heierhorst J, Tsai MD.

Mol Cell Proteomics. 2014 Feb;13(2):551-65. doi: 10.1074/mcp.M113.034058. Epub 2013 Dec 3.


Dun1 counts on rad53 to be turned on.

Zhang W, Durocher D.

Mol Cell. 2008 Jul 11;31(1):1-2. doi: 10.1016/j.molcel.2008.06.009.


Phosphorylation of Sae2 Mediates Forkhead-associated (FHA) Domain-specific Interaction and Regulates Its DNA Repair Function.

Liang J, Suhandynata RT, Zhou H.

J Biol Chem. 2015 Apr 24;290(17):10751-63. doi: 10.1074/jbc.M114.625293. Epub 2015 Mar 11.


Rad53 kinase activation-independent replication checkpoint function of the N-terminal forkhead-associated (FHA1) domain.

Pike BL, Tenis N, Heierhorst J.

J Biol Chem. 2004 Sep 17;279(38):39636-44. Epub 2004 Jul 22.


Mechanism of Dun1 activation by Rad53 phosphorylation in Saccharomyces cerevisiae.

Chen SH, Smolka MB, Zhou H.

J Biol Chem. 2007 Jan 12;282(2):986-95. Epub 2006 Nov 17.


Location-specific functions of the two forkhead-associated domains in Rad53 checkpoint kinase signaling.

Tam AT, Pike BL, Heierhorst J.

Biochemistry. 2008 Mar 25;47(12):3912-6. doi: 10.1021/bi800027t. Epub 2008 Feb 27.


Rad53 phosphorylation site clusters are important for Rad53 regulation and signaling.

Lee SJ, Schwartz MF, Duong JK, Stern DF.

Mol Cell Biol. 2003 Sep;23(17):6300-14.


Molecular basis of the essential s phase function of the rad53 checkpoint kinase.

Hoch NC, Chen ES, Buckland R, Wang SC, Fazio A, Hammet A, Pellicioli A, Chabes A, Tsai MD, Heierhorst J.

Mol Cell Biol. 2013 Aug;33(16):3202-13. doi: 10.1128/MCB.00474-13. Epub 2013 Jun 10.


Diverse but overlapping functions of the two forkhead-associated (FHA) domains in Rad53 checkpoint kinase activation.

Pike BL, Yongkiettrakul S, Tsai MD, Heierhorst J.

J Biol Chem. 2003 Aug 15;278(33):30421-4. Epub 2003 Jun 12.


Role of the N-terminal forkhead-associated domain in the cell cycle checkpoint function of the Rad53 kinase.

Pike BL, Hammet A, Heierhorst J.

J Biol Chem. 2001 Apr 27;276(17):14019-26. Epub 2001 Jan 18.


Rad9 phosphorylation sites couple Rad53 to the Saccharomyces cerevisiae DNA damage checkpoint.

Schwartz MF, Duong JK, Sun Z, Morrow JS, Pradhan D, Stern DF.

Mol Cell. 2002 May;9(5):1055-65.


The Dun1 checkpoint kinase phosphorylates and regulates the ribonucleotide reductase inhibitor Sml1.

Zhao X, Rothstein R.

Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3746-51.


Phospho-Priming Confers Functionally Relevant Specificities for Rad53 Kinase Autophosphorylation.

Chen ES, Weng JH, Chen YH, Wang SC, Liu XX, Huang WC, Matsui T, Kawano Y, Liao JH, Lim LH, Bessho Y, Huang KF, Wu WJ, Tsai MD.

Biochemistry. 2017 Sep 26;56(38):5112-5124. doi: 10.1021/acs.biochem.7b00689. Epub 2017 Sep 15.


Saccharomyces cerevisiae Rad9 acts as a Mec1 adaptor to allow Rad53 activation.

Sweeney FD, Yang F, Chi A, Shabanowitz J, Hunt DF, Durocher D.

Curr Biol. 2005 Aug 9;15(15):1364-75.


A novel non-canonical forkhead-associated (FHA) domain-binding interface mediates the interaction between Rad53 and Dbf4 proteins.

Matthews LA, Selvaratnam R, Jones DR, Akimoto M, McConkey BJ, Melacini G, Duncker BP, Guarné A.

J Biol Chem. 2014 Jan 31;289(5):2589-99. doi: 10.1074/jbc.M113.517060. Epub 2013 Nov 27.


Mechanisms of checkpoint kinase Rad53 inactivation after a double-strand break in Saccharomyces cerevisiae.

Guillemain G, Ma E, Mauger S, Miron S, Thai R, Guérois R, Ochsenbein F, Marsolier-Kergoat MC.

Mol Cell Biol. 2007 May;27(9):3378-89. Epub 2007 Feb 26.

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