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Items: 1 to 20 of 115

1.

Heterogeneous nuclear ribonucleoprotein A1 regulates cyclin D1 and c-myc internal ribosome entry site function through Akt signaling.

Jo OD, Martin J, Bernath A, Masri J, Lichtenstein A, Gera J.

J Biol Chem. 2008 Aug 22;283(34):23274-87. doi: 10.1074/jbc.M801185200. Epub 2008 Jun 18. Erratum in: J Biol Chem. 2008 Nov 7;283(45):31268.

2.

Phosphomimetic substitution of heterogeneous nuclear ribonucleoprotein A1 at serine 199 abolishes AKT-dependent internal ribosome entry site-transacting factor (ITAF) function via effects on strand annealing and results in mammalian target of rapamycin complex 1 (mTORC1) inhibitor sensitivity.

Martin J, Masri J, Cloninger C, Holmes B, Artinian N, Funk A, Ruegg T, Anderson L, Bashir T, Bernath A, Lichtenstein A, Gera J.

J Biol Chem. 2011 May 6;286(18):16402-13. doi: 10.1074/jbc.M110.205096. Epub 2011 Mar 16.

3.

AP-1 regulates cyclin D1 and c-MYC transcription in an AKT-dependent manner in response to mTOR inhibition: role of AIP4/Itch-mediated JUNB degradation.

Vartanian R, Masri J, Martin J, Cloninger C, Holmes B, Artinian N, Funk A, Ruegg T, Gera J.

Mol Cancer Res. 2011 Jan;9(1):115-30. doi: 10.1158/1541-7786.MCR-10-0105. Epub 2010 Dec 6.

4.
5.

Mechanistic Target of Rapamycin (mTOR) Inhibition Synergizes with Reduced Internal Ribosome Entry Site (IRES)-mediated Translation of Cyclin D1 and c-MYC mRNAs to Treat Glioblastoma.

Holmes B, Lee J, Landon KA, Benavides-Serrato A, Bashir T, Jung ME, Lichtenstein A, Gera J.

J Biol Chem. 2016 Jul 1;291(27):14146-59. doi: 10.1074/jbc.M116.726927. Epub 2016 May 11.

6.

IL-6-induced stimulation of c-myc translation in multiple myeloma cells is mediated by myc internal ribosome entry site function and the RNA-binding protein, hnRNP A1.

Shi Y, Frost PJ, Hoang BQ, Benavides A, Sharma S, Gera JF, Lichtenstein AK.

Cancer Res. 2008 Dec 15;68(24):10215-22. doi: 10.1158/0008-5472.CAN-08-1066.

7.

Tristetraprolin regulates Cyclin D1 and c-Myc mRNA stability in response to rapamycin in an Akt-dependent manner via p38 MAPK signaling.

Marderosian M, Sharma A, Funk AP, Vartanian R, Masri J, Jo OD, Gera JF.

Oncogene. 2006 Oct 12;25(47):6277-90. Epub 2006 May 15.

PMID:
16702957
9.

sST2 translation is regulated by FGF2 via an hnRNP A1-mediated IRES-dependent mechanism.

Kunze MM, Benz F, Brauß TF, Lampe S, Weigand JE, Braun J, Richter FM, Wittig I, Brüne B, Schmid T.

Biochim Biophys Acta. 2016 Jul;1859(7):848-59. doi: 10.1016/j.bbagrm.2016.05.005. Epub 2016 May 8.

PMID:
27168114
10.

Subcellular relocalization of a trans-acting factor regulates XIAP IRES-dependent translation.

Lewis SM, Veyrier A, Hosszu Ungureanu N, Bonnal S, Vagner S, Holcik M.

Mol Biol Cell. 2007 Apr;18(4):1302-11. Epub 2007 Feb 7.

11.

hnRNP A1 mediates the activation of the IRES-dependent SREBP-1a mRNA translation in response to endoplasmic reticulum stress.

Damiano F, Rochira A, Tocci R, Alemanno S, Gnoni A, Siculella L.

Biochem J. 2013 Jan 15;449(2):543-53. doi: 10.1042/BJ20120906.

PMID:
23106379
12.

AKT activity determines sensitivity to mammalian target of rapamycin (mTOR) inhibitors by regulating cyclin D1 and c-myc expression.

Gera JF, Mellinghoff IK, Shi Y, Rettig MB, Tran C, Hsu JH, Sawyers CL, Lichtenstein AK.

J Biol Chem. 2004 Jan 23;279(4):2737-46. Epub 2003 Oct 23.

13.
14.

Heterogeneous nuclear ribonucleoprotein C modulates translation of c-myc mRNA in a cell cycle phase-dependent manner.

Kim JH, Paek KY, Choi K, Kim TD, Hahm B, Kim KT, Jang SK.

Mol Cell Biol. 2003 Jan;23(2):708-20.

15.

IL-6-induced enhancement of c-Myc translation in multiple myeloma cells: critical role of cytoplasmic localization of the rna-binding protein hnRNP A1.

Shi Y, Frost P, Hoang B, Benavides A, Gera J, Lichtenstein A.

J Biol Chem. 2011 Jan 7;286(1):67-78. doi: 10.1074/jbc.M110.153221. Epub 2010 Oct 25.

16.

PRMT5 regulates IRES-dependent translation via methylation of hnRNP A1.

Gao G, Dhar S, Bedford MT.

Nucleic Acids Res. 2017 May 5;45(8):4359-4369. doi: 10.1093/nar/gkw1367.

17.

Cytoplasmic relocalization of heterogeneous nuclear ribonucleoprotein A1 controls translation initiation of specific mRNAs.

Cammas A, Pileur F, Bonnal S, Lewis SM, Lévêque N, Holcik M, Vagner S.

Mol Biol Cell. 2007 Dec;18(12):5048-59. Epub 2007 Sep 26.

18.

Identification of internal ribosome entry segment (IRES)-trans-acting factors for the Myc family of IRESs.

Cobbold LC, Spriggs KA, Haines SJ, Dobbyn HC, Hayes C, de Moor CH, Lilley KS, Bushell M, Willis AE.

Mol Cell Biol. 2008 Jan;28(1):40-9. Epub 2007 Oct 29.

19.

hnRNP A1 interacts with the 5' untranslated regions of enterovirus 71 and Sindbis virus RNA and is required for viral replication.

Lin JY, Shih SR, Pan M, Li C, Lue CF, Stollar V, Li ML.

J Virol. 2009 Jun;83(12):6106-14. doi: 10.1128/JVI.02476-08. Epub 2009 Apr 1.

20.

Inhibition of SAPK2/p38 enhances sensitivity to mTORC1 inhibition by blocking IRES-mediated translation initiation in glioblastoma.

Cloninger C, Bernath A, Bashir T, Holmes B, Artinian N, Ruegg T, Anderson L, Masri J, Lichtenstein A, Gera J.

Mol Cancer Ther. 2011 Dec;10(12):2244-56. doi: 10.1158/1535-7163.MCT-11-0478. Epub 2011 Sep 12.

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