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Items: 1 to 20 of 96

1.

Shape shifting leads to small-molecule allosteric drug discovery.

Lawrence SH, Ramirez UD, Tang L, Fazliyez F, Kundrat L, Markham GD, Jaffe EK.

Chem Biol. 2008 Jun;15(6):586-96. doi: 10.1016/j.chembiol.2008.04.012.

2.

Docking to large allosteric binding sites on protein surfaces.

Ramirez UD, Myachina F, Stith L, Jaffe EK.

Adv Exp Med Biol. 2010;680:481-8. doi: 10.1007/978-1-4419-5913-3_54.

3.

The Remarkable Character of Porphobilinogen Synthase.

Jaffe EK.

Acc Chem Res. 2016 Oct 26. [Epub ahead of print]

PMID:
27783504
4.

Allosteric inhibition of human porphobilinogen synthase.

Lawrence SH, Ramirez UD, Selwood T, Stith L, Jaffe EK.

J Biol Chem. 2009 Dec 18;284(51):35807-17. doi: 10.1074/jbc.M109.026294.

5.

Allostery and the dynamic oligomerization of porphobilinogen synthase.

Jaffe EK, Lawrence SH.

Arch Biochem Biophys. 2012 Mar 15;519(2):144-53. doi: 10.1016/j.abb.2011.10.010. Review.

6.

Kinetics and thermodynamics of the interchange of the morpheein forms of human porphobilinogen synthase.

Selwood T, Tang L, Lawrence SH, Anokhina Y, Jaffe EK.

Biochemistry. 2008 Mar 11;47(10):3245-57. doi: 10.1021/bi702113z.

PMID:
18271513
7.

Probing the oligomeric assemblies of pea porphobilinogen synthase by analytical ultracentrifugation.

Kokona B, Rigotti DJ, Wasson AS, Lawrence SH, Jaffe EK, Fairman R.

Biochemistry. 2008 Oct 7;47(40):10649-56. doi: 10.1021/bi801128d.

8.
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10.

Single amino acid mutations alter the distribution of human porphobilinogen synthase quaternary structure isoforms (morpheeins).

Tang L, Breinig S, Stith L, Mischel A, Tannir J, Kokona B, Fairman R, Jaffe EK.

J Biol Chem. 2006 Mar 10;281(10):6682-90.

11.
12.

Control of tetrapyrrole biosynthesis by alternate quaternary forms of porphobilinogen synthase.

Breinig S, Kervinen J, Stith L, Wasson AS, Fairman R, Wlodawer A, Zdanov A, Jaffe EK.

Nat Struct Biol. 2003 Sep;10(9):757-63.

PMID:
12897770
13.
14.

The morpheein model of allostery: evaluating proteins as potential morpheeins.

Jaffe EK, Lawrence SH.

Methods Mol Biol. 2012;796:217-31. doi: 10.1007/978-1-61779-334-9_12.

15.

ALAD porphyria is a conformational disease.

Jaffe EK, Stith L.

Am J Hum Genet. 2007 Feb;80(2):329-37.

16.

Morpheeins--a new structural paradigm for allosteric regulation.

Jaffe EK.

Trends Biochem Sci. 2005 Sep;30(9):490-7. Review.

PMID:
16023348
17.
18.

Rhodobacter capsulatus porphobilinogen synthase, a high activity metal ion independent hexamer.

Bollivar DW, Clauson C, Lighthall R, Forbes S, Kokona B, Fairman R, Kundrat L, Jaffe EK.

BMC Biochem. 2004 Nov 22;5:17.

19.

Porphobilinogen synthase, the first source of heme's asymmetry.

Jaffe EK.

J Bioenerg Biomembr. 1995 Apr;27(2):169-79. Review.

PMID:
7592564
20.

Comparative analysis of folding and substrate binding sites between regulated hexameric type II citrate synthases and unregulated dimeric type I enzymes.

Nguyen NT, Maurus R, Stokell DJ, Ayed A, Duckworth HW, Brayer GD.

Biochemistry. 2001 Nov 6;40(44):13177-87.

PMID:
11683626
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