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Items: 1 to 20 of 84

1.

The amyotrophic lateral sclerosis 8 protein VAPB is cleaved, secreted, and acts as a ligand for Eph receptors.

Tsuda H, Han SM, Yang Y, Tong C, Lin YQ, Mohan K, Haueter C, Zoghbi A, Harati Y, Kwan J, Miller MA, Bellen HJ.

Cell. 2008 Jun 13;133(6):963-77. doi: 10.1016/j.cell.2008.04.039.

2.

The amyotrophic lateral sclerosis 8 protein, VAP, is required for ER protein quality control.

Moustaqim-Barrette A, Lin YQ, Pradhan S, Neely GG, Bellen HJ, Tsuda H.

Hum Mol Genet. 2014 Apr 15;23(8):1975-89. doi: 10.1093/hmg/ddt594. Epub 2013 Nov 23.

3.

VAPB interacts with and modulates the activity of ATF6.

Gkogkas C, Middleton S, Kremer AM, Wardrope C, Hannah M, Gillingwater TH, Skehel P.

Hum Mol Genet. 2008 Jun 1;17(11):1517-26. doi: 10.1093/hmg/ddn040. Epub 2008 Feb 8.

PMID:
18263603
4.

From ER to Eph receptors: new roles for VAP fragments.

Ackerman SL, Cox GA.

Cell. 2008 Jun 13;133(6):949-51. doi: 10.1016/j.cell.2008.05.028.

5.

VAPB/ALS8 MSP ligands regulate striated muscle energy metabolism critical for adult survival in caenorhabditis elegans.

Han SM, El Oussini H, Scekic-Zahirovic J, Vibbert J, Cottee P, Prasain JK, Bellen HJ, Dupuis L, Miller MA.

PLoS Genet. 2013;9(9):e1003738. doi: 10.1371/journal.pgen.1003738. Epub 2013 Sep 5.

6.

Restructured endoplasmic reticulum generated by mutant amyotrophic lateral sclerosis-linked VAPB is cleared by the proteasome.

Papiani G, Ruggiano A, Fossati M, Raimondi A, Bertoni G, Francolini M, Benfante R, Navone F, Borgese N.

J Cell Sci. 2012 Aug 1;125(Pt 15):3601-11. Epub 2012 May 18.

7.

A mutation in human VAP-B--MSP domain, present in ALS patients, affects the interaction with other cellular proteins.

Mitne-Neto M, Ramos CR, Pimenta DC, Luz JS, Nishimura AL, Gonzales FA, Oliveira CC, Zatz M.

Protein Expr Purif. 2007 Sep;55(1):139-46. Epub 2007 Apr 20.

PMID:
17540579
8.

Structural, stability, dynamic and binding properties of the ALS-causing T46I mutant of the hVAPB MSP domain as revealed by NMR and MD simulations.

Lua S, Qin H, Lim L, Shi J, Gupta G, Song J.

PLoS One. 2011;6(11):e27072. doi: 10.1371/journal.pone.0027072. Epub 2011 Nov 1.

9.

Motor neuron disease-associated mutant vesicle-associated membrane protein-associated protein (VAP) B recruits wild-type VAPs into endoplasmic reticulum-derived tubular aggregates.

Teuling E, Ahmed S, Haasdijk E, Demmers J, Steinmetz MO, Akhmanova A, Jaarsma D, Hoogenraad CC.

J Neurosci. 2007 Sep 5;27(36):9801-15.

10.

The ALS8 protein VAPB interacts with the ER-Golgi recycling protein YIF1A and regulates membrane delivery into dendrites.

Kuijpers M, Yu KL, Teuling E, Akhmanova A, Jaarsma D, Hoogenraad CC.

EMBO J. 2013 Jul 17;32(14):2056-72. doi: 10.1038/emboj.2013.131. Epub 2013 Jun 4.

11.

Structural requirements for VAP-B oligomerization and their implication in amyotrophic lateral sclerosis-associated VAP-B(P56S) neurotoxicity.

Kim S, Leal SS, Ben Halevy D, Gomes CM, Lev S.

J Biol Chem. 2010 Apr 30;285(18):13839-49. doi: 10.1074/jbc.M109.097345. Epub 2010 Mar 5.

12.

ALS-linked P56S-VAPB, an aggregated loss-of-function mutant of VAPB, predisposes motor neurons to ER stress-related death by inducing aggregation of co-expressed wild-type VAPB.

Suzuki H, Kanekura K, Levine TP, Kohno K, Olkkonen VM, Aiso S, Matsuoka M.

J Neurochem. 2009 Feb;108(4):973-985. doi: 10.1111/j.0022-3042.2008.05857.x.

13.

Expression of vesicle-associated membrane-protein-associated protein B cleavage products in peripheral blood leukocytes and cerebrospinal fluid of patients with sporadic amyotrophic lateral sclerosis.

Deidda I, Galizzi G, Passantino R, Cascio C, Russo D, Colletti T, La Bella V, Guarneri P.

Eur J Neurol. 2014 Mar;21(3):478-85. doi: 10.1111/ene.12334. Epub 2013 Dec 26.

PMID:
24372953
14.

Galphao/i and Galphas signaling function in parallel with the MSP/Eph receptor to control meiotic diapause in C. elegans.

Govindan JA, Cheng H, Harris JE, Greenstein D.

Curr Biol. 2006 Jul 11;16(13):1257-68.

15.

Characterization of amyotrophic lateral sclerosis-linked P56S mutation of vesicle-associated membrane protein-associated protein B (VAPB/ALS8).

Kanekura K, Nishimoto I, Aiso S, Matsuoka M.

J Biol Chem. 2006 Oct 6;281(40):30223-33. Epub 2006 Aug 4.

16.

Investigating the contribution of VAPB/ALS8 loss of function in amyotrophic lateral sclerosis.

Kabashi E, El Oussini H, Bercier V, Gros-Louis F, Valdmanis PN, McDearmid J, Mejier IA, Dion PA, Dupre N, Hollinger D, Sinniger J, Dirrig-Grosch S, Camu W, Meininger V, Loeffler JP, René F, Drapeau P, Rouleau GA, Dupuis L.

Hum Mol Genet. 2013 Jun 15;22(12):2350-60. doi: 10.1093/hmg/ddt080. Epub 2013 Feb 26.

PMID:
23446633
17.

ALS-causing P56S mutation and splicing variation on the hVAPB MSP domain transform its β-sandwich fold into lipid-interacting helical conformations.

Qin H, Wang W, Song J.

Biochem Biophys Res Commun. 2013 Feb 15;431(3):398-403. doi: 10.1016/j.bbrc.2013.01.039. Epub 2013 Jan 16.

PMID:
23333387
18.

FFAT rescues VAPA-mediated inhibition of ER-to-Golgi transport and VAPB-mediated ER aggregation.

Prosser DC, Tran D, Gougeon PY, Verly C, Ngsee JK.

J Cell Sci. 2008 Sep 15;121(Pt 18):3052-61. doi: 10.1242/jcs.028696. Epub 2008 Aug 19.

19.

Secreted VAPB/ALS8 major sperm protein domains modulate mitochondrial localization and morphology via growth cone guidance receptors.

Han SM, Tsuda H, Yang Y, Vibbert J, Cottee P, Lee SJ, Winek J, Haueter C, Bellen HJ, Miller MA.

Dev Cell. 2012 Feb 14;22(2):348-62. doi: 10.1016/j.devcel.2011.12.009. Epub 2012 Jan 19.

20.

VAPB/ALS8 interacts with FFAT-like proteins including the p97 cofactor FAF1 and the ASNA1 ATPase.

Baron Y, Pedrioli PG, Tyagi K, Johnson C, Wood NT, Fountaine D, Wightman M, Alexandru G.

BMC Biol. 2014 May 29;12:39. doi: 10.1186/1741-7007-12-39.

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