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Items: 1 to 20 of 102

1.

Structures of DNA polymerase beta with active-site mismatches suggest a transient abasic site intermediate during misincorporation.

Batra VK, Beard WA, Shock DD, Pedersen LC, Wilson SH.

Mol Cell. 2008 May 9;30(3):315-24. doi: 10.1016/j.molcel.2008.02.025.

2.

Mismatch-induced conformational distortions in polymerase beta support an induced-fit mechanism for fidelity.

Arora K, Beard WA, Wilson SH, Schlick T.

Biochemistry. 2005 Oct 11;44(40):13328-41.

PMID:
16201758
3.

DNA polymerase beta substrate specificity: side chain modulation of the "A-rule".

Beard WA, Shock DD, Batra VK, Pedersen LC, Wilson SH.

J Biol Chem. 2009 Nov 13;284(46):31680-9. doi: 10.1074/jbc.M109.029843. Epub 2009 Sep 15.

4.

Influence of DNA structure on DNA polymerase beta active site function: extension of mutagenic DNA intermediates.

Beard WA, Shock DD, Wilson SH.

J Biol Chem. 2004 Jul 23;279(30):31921-9. Epub 2004 May 15.

5.
6.

Mismatched base-pair simulations for ASFV Pol X/DNA complexes help interpret frequent G*G misincorporation.

Sampoli Benítez BA, Arora K, Balistreri L, Schlick T.

J Mol Biol. 2008 Dec 31;384(5):1086-97. doi: 10.1016/j.jmb.2008.10.025. Epub 2008 Oct 17.

7.

The spontaneous replication error and the mismatch discrimination mechanisms of human DNA polymerase β.

Koag MC, Nam K, Lee S.

Nucleic Acids Res. 2014;42(17):11233-45. doi: 10.1093/nar/gku789. Epub 2014 Sep 8.

8.

Local deformations revealed by dynamics simulations of DNA polymerase Beta with DNA mismatches at the primer terminus.

Yang L, Beard W, Wilson S, Roux B, Broyde S, Schlick T.

J Mol Biol. 2002 Aug 16;321(3):459-78.

PMID:
12162959
9.

Loss of DNA polymerase beta stacking interactions with templating purines, but not pyrimidines, alters catalytic efficiency and fidelity.

Beard WA, Shock DD, Yang XP, DeLauder SF, Wilson SH.

J Biol Chem. 2002 Mar 8;277(10):8235-42. Epub 2001 Dec 26.

10.

Structures of DNA Polymerase Mispaired DNA Termini Transitioning to Pre-catalytic Complexes Support an Induced-Fit Fidelity Mechanism.

Batra VK, Beard WA, Pedersen LC, Wilson SH.

Structure. 2016 Nov 1;24(11):1863-1875. doi: 10.1016/j.str.2016.08.006. Epub 2016 Sep 15.

PMID:
27642161
12.

DNA structure and polymerase fidelity.

Timsit Y.

J Mol Biol. 1999 Nov 5;293(4):835-53.

PMID:
10543971
13.

A DNA polymerase beta mutator mutant with reduced nucleotide discrimination and increased protein stability.

Shah AM, Conn DA, Li SX, Capaldi A, Jäger J, Sweasy JB.

Biochemistry. 2001 Sep 25;40(38):11372-81.

PMID:
11560485
14.

Structural basis for promutagenicity of 8-halogenated guanine.

Koag MC, Min K, Lee S.

J Biol Chem. 2014 Feb 28;289(9):6289-98. doi: 10.1074/jbc.M113.537803. Epub 2014 Jan 14.

15.

Snapshots of a Y-family DNA polymerase in replication: substrate-induced conformational transitions and implications for fidelity of Dpo4.

Wong JH, Fiala KA, Suo Z, Ling H.

J Mol Biol. 2008 May 30;379(2):317-30. doi: 10.1016/j.jmb.2008.03.038. Epub 2008 Mar 28.

PMID:
18448122
16.

Nucleotide-induced DNA polymerase active site motions accommodating a mutagenic DNA intermediate.

Batra VK, Beard WA, Shock DD, Pedersen LC, Wilson SH.

Structure. 2005 Aug;13(8):1225-33.

17.

Fidelity of Dpo4: effect of metal ions, nucleotide selection and pyrophosphorolysis.

Vaisman A, Ling H, Woodgate R, Yang W.

EMBO J. 2005 Sep 7;24(17):2957-67. Epub 2005 Aug 18.

18.
19.

Observing a DNA polymerase choose right from wrong.

Freudenthal BD, Beard WA, Shock DD, Wilson SH.

Cell. 2013 Jul 3;154(1):157-68. doi: 10.1016/j.cell.2013.05.048.

20.

Minor groove interactions at the DNA polymerase beta active site modulate single-base deletion error rates.

Osheroff WP, Beard WA, Yin S, Wilson SH, Kunkel TA.

J Biol Chem. 2000 Sep 8;275(36):28033-8.

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