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Items: 1 to 20 of 115


Identification of genetic and chemical modulators of zebrafish mechanosensory hair cell death.

Owens KN, Santos F, Roberts B, Linbo T, Coffin AB, Knisely AJ, Simon JA, Rubel EW, Raible DW.

PLoS Genet. 2008 Feb 29;4(2):e1000020. doi: 10.1371/journal.pgen.1000020.


Screen of FDA-approved drug library reveals compounds that protect hair cells from aminoglycosides and cisplatin.

Vlasits AL, Simon JA, Raible DW, Rubel EW, Owens KN.

Hear Res. 2012 Dec;294(1-2):153-65. doi: 10.1016/j.heares.2012.08.002. Epub 2012 Aug 31.


Response of mechanosensory hair cells of the zebrafish lateral line to aminoglycosides reveals distinct cell death pathways.

Owens KN, Coffin AB, Hong LS, Bennett KO, Rubel EW, Raible DW.

Hear Res. 2009 Jul;253(1-2):32-41. doi: 10.1016/j.heares.2009.03.001. Epub 2009 Mar 11.


Loss of Slc4a1b chloride/bicarbonate exchanger function protects mechanosensory hair cells from aminoglycoside damage in the zebrafish mutant persephone.

Hailey DW, Roberts B, Owens KN, Stewart AK, Linbo T, Pujol R, Alper SL, Rubel EW, Raible DW.

PLoS Genet. 2012;8(10):e1002971. doi: 10.1371/journal.pgen.1002971. Epub 2012 Oct 11.


Identification of FDA-approved drugs and bioactives that protect hair cells in the zebrafish (Danio rerio) lateral line and mouse (Mus musculus) utricle.

Ou HC, Cunningham LL, Francis SP, Brandon CS, Simon JA, Raible DW, Rubel EW.

J Assoc Res Otolaryngol. 2009 Jun;10(2):191-203. doi: 10.1007/s10162-009-0158-y. Epub 2009 Feb 25.


Extracellular divalent cations modulate aminoglycoside-induced hair cell death in the zebrafish lateral line.

Coffin AB, Reinhart KE, Owens KN, Raible DW, Rubel EW.

Hear Res. 2009 Jul;253(1-2):42-51. doi: 10.1016/j.heares.2009.03.004. Epub 2009 Mar 12.


Profiling drug-induced cell death pathways in the zebrafish lateral line.

Coffin AB, Williamson KL, Mamiya A, Raible DW, Rubel EW.

Apoptosis. 2013 Apr;18(4):393-408. doi: 10.1007/s10495-013-0816-8.


Identification of small molecule inhibitors of cisplatin-induced hair cell death: results of a 10,000 compound screen in the zebrafish lateral line.

Thomas AJ, Wu P, Raible DW, Rubel EW, Simon JA, Ou HC.

Otol Neurotol. 2015 Mar;36(3):519-25. doi: 10.1097/MAO.0000000000000487.


Using the zebrafish lateral line to screen for ototoxicity.

Chiu LL, Cunningham LL, Raible DW, Rubel EW, Ou HC.

J Assoc Res Otolaryngol. 2008 Jun;9(2):178-90. doi: 10.1007/s10162-008-0118-y. Epub 2008 Apr 12.


Bax, Bcl2, and p53 differentially regulate neomycin- and gentamicin-induced hair cell death in the zebrafish lateral line.

Coffin AB, Rubel EW, Raible DW.

J Assoc Res Otolaryngol. 2013 Oct;14(5):645-59. doi: 10.1007/s10162-013-0404-1. Epub 2013 Jul 3.


Celastrol inhibits aminoglycoside-induced ototoxicity via heat shock protein 32.

Francis SP, Kramarenko II, Brandon CS, Lee FS, Baker TG, Cunningham LL.

Cell Death Dis. 2011 Aug 25;2:e195. doi: 10.1038/cddis.2011.76.


Developmental differences in susceptibility to neomycin-induced hair cell death in the lateral line neuromasts of zebrafish (Danio rerio).

Murakami SL, Cunningham LL, Werner LA, Bauer E, Pujol R, Raible DW, Rubel EW.

Hear Res. 2003 Dec;186(1-2):47-56.


Sound preconditioning therapy inhibits ototoxic hearing loss in mice.

Roy S, Ryals MM, Van den Bruele AB, Fitzgerald TS, Cunningham LL.

J Clin Invest. 2013 Nov;123(11):4945-9. Erratum in: J Clin Invest. 2014 Jan 2;124(1):461.


Drug screening for hearing loss: using the zebrafish lateral line to screen for drugs that prevent and cause hearing loss.

Ou HC, Santos F, Raible DW, Simon JA, Rubel EW.

Drug Discov Today. 2010 Apr;15(7-8):265-71. doi: 10.1016/j.drudis.2010.01.001. Epub 2010 Jan 22. Review.


Hsp70 inhibits aminoglycoside-induced hair cell death and is necessary for the protective effect of heat shock.

Taleb M, Brandon CS, Lee FS, Lomax MI, Dillmann WH, Cunningham LL.

J Assoc Res Otolaryngol. 2008 Sep;9(3):277-89. doi: 10.1007/s10162-008-0122-2. Epub 2008 May 30.


The zebrafish merovingian mutant reveals a role for pH regulation in hair cell toxicity and function.

Stawicki TM, Owens KN, Linbo T, Reinhart KE, Rubel EW, Raible DW.

Dis Model Mech. 2014 Jul;7(7):847-56. doi: 10.1242/dmm.016576.


Using the zebrafish lateral line to uncover novel mechanisms of action and prevention in drug-induced hair cell death.

Stawicki TM, Esterberg R, Hailey DW, Raible DW, Rubel EW.

Front Cell Neurosci. 2015 Feb 18;9:46. doi: 10.3389/fncel.2015.00046. eCollection 2015. Review.


Natural Bizbenzoquinoline Derivatives Protect Zebrafish Lateral Line Sensory Hair Cells from Aminoglycoside Toxicity.

Kruger M, Boney R, Ordoobadi AJ, Sommers TF, Trapani JG, Coffin AB.

Front Cell Neurosci. 2016 Mar 30;10:83. doi: 10.3389/fncel.2016.00083. eCollection 2016.


Heat shock inhibits both aminoglycoside- and cisplatin-induced sensory hair cell death.

Cunningham LL, Brandon CS.

J Assoc Res Otolaryngol. 2006 Sep;7(3):299-307. Epub 2006 Jun 23.


Live imaging the phagocytic activity of inner ear supporting cells in response to hair cell death.

Monzack EL, May LA, Roy S, Gale JE, Cunningham LL.

Cell Death Differ. 2015 Dec;22(12):1995-2005. doi: 10.1038/cdd.2015.48. Epub 2015 May 1.

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