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Items: 1 to 20 of 273

1.

Common variants near MC4R are associated with fat mass, weight and risk of obesity.

Loos RJ, Lindgren CM, Li S, Wheeler E, Zhao JH, Prokopenko I, Inouye M, Freathy RM, Attwood AP, Beckmann JS, Berndt SI; Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, Jacobs KB, Chanock SJ, Hayes RB, Bergmann S, Bennett AJ, Bingham SA, Bochud M, Brown M, Cauchi S, Connell JM, Cooper C, Smith GD, Day I, Dina C, De S, Dermitzakis ET, Doney AS, Elliott KS, Elliott P, Evans DM, Sadaf Farooqi I, Froguel P, Ghori J, Groves CJ, Gwilliam R, Hadley D, Hall AS, Hattersley AT, Hebebrand J, Heid IM; KORA, Lamina C, Gieger C, Illig T, Meitinger T, Wichmann HE, Herrera B, Hinney A, Hunt SE, Jarvelin MR, Johnson T, Jolley JD, Karpe F, Keniry A, Khaw KT, Luben RN, Mangino M, Marchini J, McArdle WL, McGinnis R, Meyre D, Munroe PB, Morris AD, Ness AR, Neville MJ, Nica AC, Ong KK, O'Rahilly S, Owen KR, Palmer CN, Papadakis K, Potter S, Pouta A, Qi L; Nurses' Health Study, Randall JC, Rayner NW, Ring SM, Sandhu MS, Scherag A, Sims MA, Song K, Soranzo N, Speliotes EK; Diabetes Genetics Initiative, Syddall HE, Teichmann SA, Timpson NJ, Tobias JH, Uda M; SardiNIA Study, Vogel CI, Wallace C, Waterworth DM, Weedon MN; Wellcome Trust Case Control Consortium, Willer CJ; FUSION, Wraight, Yuan X, Zeggini E, Hirschhorn JN, Strachan DP, Ouwehand WH, Caulfield MJ, Samani NJ, Frayling TM, Vollenweider P, Waeber G, Mooser V, Deloukas P, McCarthy MI, Wareham NJ, Barroso I, Jacobs KB, Chanock SJ, Hayes RB, Lamina C, Gieger C, Illig T, Meitinger T, Wichmann HE, Kraft P, Hankinson SE, Hunter DJ, Hu FB, Lyon HN, Voight BF, Ridderstrale M, Groop L, Scheet P, Sanna S, Abecasis GR, Albai G, Nagaraja R, Schlessinger D, Jackson AU, Tuomilehto J, Collins FS, Boehnke M, Mohlke KL.

Nat Genet. 2008 Jun;40(6):768-75. doi: 10.1038/ng.140. Epub 2008 May 4.

2.

Combined effects of MC4R and FTO common genetic variants on obesity in European general populations.

Cauchi S, Stutzmann F, Cavalcanti-Proença C, Durand E, Pouta A, Hartikainen AL, Marre M, Vol S, Tammelin T, Laitinen J, Gonzalez-Izquierdo A, Blakemore AI, Elliott P, Meyre D, Balkau B, Järvelin MR, Froguel P.

J Mol Med (Berl). 2009 May;87(5):537-46. doi: 10.1007/s00109-009-0451-6. Epub 2009 Mar 3.

PMID:
19255736
3.

Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits.

Scuteri A, Sanna S, Chen WM, Uda M, Albai G, Strait J, Najjar S, Nagaraja R, Orrú M, Usala G, Dei M, Lai S, Maschio A, Busonero F, Mulas A, Ehret GB, Fink AA, Weder AB, Cooper RS, Galan P, Chakravarti A, Schlessinger D, Cao A, Lakatta E, Abecasis GR.

PLoS Genet. 2007 Jul;3(7):e115.

4.

Strong influence of variants near MC4R on adiposity in children and adults: a cross-sectional study in Indian population.

Dwivedi OP, Tabassum R, Chauhan G, Kaur I, Ghosh S, Marwaha RK, Tandon N, Bharadwaj D.

J Hum Genet. 2013 Jan;58(1):27-32. doi: 10.1038/jhg.2012.129. Epub 2012 Nov 15.

PMID:
23151679
5.

Associations of variants in FTO and near MC4R with obesity traits in South Asian Indians.

Vasan SK, Fall T, Neville MJ, Antonisamy B, Fall CH, Geethanjali FS, Gu HF, Raghupathy P, Samuel P, Thomas N, Brismar K, Ingelsson E, Karpe F.

Obesity (Silver Spring). 2012 Nov;20(11):2268-77. doi: 10.1038/oby.2012.64. Epub 2012 Mar 16.

6.

Effects of FTO RS9939906 and MC4R RS17782313 on obesity, type 2 diabetes mellitus and blood pressure in patients with hypertension.

Marcadenti A, Fuchs FD, Matte U, Sperb F, Moreira LB, Fuchs SC.

Cardiovasc Diabetol. 2013 Jul 12;12:103. doi: 10.1186/1475-2840-12-103.

7.

Replication of genetic effects of MC4R polymorphisms on body mass index in a Korean population.

Sull JW, Lee M, Jee SH.

Endocrine. 2013 Dec;44(3):675-9. doi: 10.1007/s12020-013-9909-y. Epub 2013 Mar 5.

PMID:
23460509
8.

Sex-specific effects of weight-affecting gene variants in a life course perspective--The HUNT Study, Norway.

Kvaløy K, Kulle B, Romundstad P, Holmen TL.

Int J Obes (Lond). 2013 Sep;37(9):1221-9. doi: 10.1038/ijo.2012.220. Epub 2013 Jan 15.

PMID:
23318717
9.

Analysis of the contribution of FTO, NPC1, ENPP1, NEGR1, GNPDA2 and MC4R genes to obesity in Mexican children.

Mejía-Benítez A, Klünder-Klünder M, Yengo L, Meyre D, Aradillas C, Cruz E, Pérez-Luque E, Malacara JM, Garay ME, Peralta-Romero J, Flores-Huerta S, García-Mena J, Froguel P, Cruz M, Bonnefond A.

BMC Med Genet. 2013 Feb 1;14:21. doi: 10.1186/1471-2350-14-21.

10.

Implication of European-derived adiposity loci in African Americans.

Hester JM, Wing MR, Li J, Palmer ND, Xu J, Hicks PJ, Roh BH, Norris JM, Wagenknecht LE, Langefeld CD, Freedman BI, Bowden DW, Ng MC.

Int J Obes (Lond). 2012 Mar;36(3):465-73. doi: 10.1038/ijo.2011.131. Epub 2011 Jul 12.

11.

[Association of polymorphic variants of FTO and MC4R genes with obesity in a Tatar population].

Kochetova OV, Korytina GF, Akhmadishina LZ, Semenov EE, Viktorova TV.

Genetika. 2015 Feb;51(2):248-55. Russian.

PMID:
25966591
12.

Common genetic variation in and near the melanocortin 4 receptor gene (MC4R) is associated with body mass index in American Indian adults and children.

Muller YL, Thearle MS, Piaggi P, Hanson RL, Hoffman D, Gene B, Mahkee D, Huang K, Kobes S, Votruba S, Knowler WC, Bogardus C, Baier LJ.

Hum Genet. 2014 Nov;133(11):1431-41. doi: 10.1007/s00439-014-1477-6. Epub 2014 Aug 8.

13.

Influence of common variants in FTO and near INSIG2 and MC4R on growth curves for adiposity in African- and European-American youth.

Liu G, Zhu H, Dong Y, Podolsky RH, Treiber FA, Snieder H.

Eur J Epidemiol. 2011 Jun;26(6):463-73. doi: 10.1007/s10654-011-9583-4. Epub 2011 May 5.

14.

Variants near MC4R are associated with obesity and influence obesity-related quantitative traits in a population of middle-aged people: studies of 14,940 Danes.

Zobel DP, Andreasen CH, Grarup N, Eiberg H, Sørensen TI, Sandbaek A, Lauritzen T, Borch-Johnsen K, Jørgensen T, Pedersen O, Hansen T.

Diabetes. 2009 Mar;58(3):757-64. doi: 10.2337/db08-0620. Epub 2008 Dec 10.

15.

Associations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulated by diet, being higher when adherence to the Mediterranean diet pattern is low.

Ortega-Azorín C, Sorlí JV, Asensio EM, Coltell O, Martínez-González MÁ, Salas-Salvadó J, Covas MI, Arós F, Lapetra J, Serra-Majem L, Gómez-Gracia E, Fiol M, Sáez-Tormo G, Pintó X, Muñoz MA, Ros E, Ordovás JM, Estruch R, Corella D.

Cardiovasc Diabetol. 2012 Nov 6;11:137. doi: 10.1186/1475-2840-11-137.

16.

Genetic association study of adiposity and melanocortin-4 receptor (MC4R) common variants: replication and functional characterization of non-coding regions.

Evans DS, Calton MA, Kim MJ, Kwok PY, Miljkovic I, Harris T, Koster A, Liu Y, Tranah GJ, Ahituv N, Hsueh WC, Vaisse C.

PLoS One. 2014 May 12;9(5):e96805. doi: 10.1371/journal.pone.0096805. eCollection 2014.

17.

The role of common and rare MC4R variants and FTO polymorphisms in extreme form of obesity.

Rovite V, Petrovska R, Vaivade I, Kalnina I, Fridmanis D, Zaharenko L, Peculis R, Pirags V, Schioth HB, Klovins J.

Mol Biol Rep. 2014 Mar;41(3):1491-500. doi: 10.1007/s11033-013-2994-4. Epub 2014 Jan 3.

PMID:
24385306
18.

Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women.

Croteau-Chonka DC, Marvelle AF, Lange EM, Lee NR, Adair LS, Lange LA, Mohlke KL.

Obesity (Silver Spring). 2011 May;19(5):1019-27. doi: 10.1038/oby.2010.256. Epub 2010 Oct 21.

19.

Common variants near MC4R in relation to body fat, body fat distribution, metabolic traits and energy expenditure.

Kring SI, Holst C, Toubro S, Astrup A, Hansen T, Pedersen O, Sørensen TI.

Int J Obes (Lond). 2010 Jan;34(1):182-9. doi: 10.1038/ijo.2009.215. Epub 2009 Oct 20.

PMID:
19844209
20.

Common genetic variation near MC4R is associated with eating behaviour patterns in European populations.

Stutzmann F, Cauchi S, Durand E, Calvacanti-Proença C, Pigeyre M, Hartikainen AL, Sovio U, Tichet J, Marre M, Weill J, Balkau B, Potoczna N, Laitinen J, Elliott P, Järvelin MR, Horber F, Meyre D, Froguel P.

Int J Obes (Lond). 2009 Mar;33(3):373-8. doi: 10.1038/ijo.2008.279. Epub 2009 Jan 20.

PMID:
19153581

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