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Items: 1 to 20 of 112

1.

Oxidative stress during diabetic pregnancy disrupts cardiac neural crest migration and causes outflow tract defects.

Morgan SC, Relaix F, Sandell LL, Loeken MR.

Birth Defects Res A Clin Mol Teratol. 2008 Jun;82(6):453-63. doi: 10.1002/bdra.20457.

2.

Cardiac outflow tract septation failure in Pax3-deficient embryos is due to p53-dependent regulation of migrating cardiac neural crest.

Morgan SC, Lee HY, Relaix F, Sandell LL, Levorse JM, Loeken MR.

Mech Dev. 2008 Sep-Oct;125(9-10):757-67. doi: 10.1016/j.mod.2008.07.003. Epub 2008 Jul 13.

3.

Advances in understanding the molecular causes of diabetes-induced birth defects.

Loeken MR.

J Soc Gynecol Investig. 2006 Jan;13(1):2-10. Epub 2005 Nov 21.

PMID:
16303321
5.

AMP-activated protein kinase mediates effects of oxidative stress on embryo gene expression in a mouse model of diabetic embryopathy.

Wu Y, Viana M, Thirumangalathu S, Loeken MR.

Diabetologia. 2012 Jan;55(1):245-54. doi: 10.1007/s00125-011-2326-y. Epub 2011 Oct 13.

6.

Oxidant regulation of gene expression and neural tube development: Insights gained from diabetic pregnancy on molecular causes of neural tube defects.

Chang TI, Horal M, Jain SK, Wang F, Patel R, Loeken MR.

Diabetologia. 2003 Apr;46(4):538-45. Epub 2003 Mar 26.

PMID:
12739027
7.

Migration of cardiac neural crest cells in Splotch embryos.

Epstein JA, Li J, Lang D, Chen F, Brown CB, Jin F, Lu MM, Thomas M, Liu E, Wessels A, Lo CW.

Development. 2000 May;127(9):1869-78.

8.

Pax3 is essential for normal cardiac neural crest morphogenesis but is not required during migration nor outflow tract septation.

Olaopa M, Zhou HM, Snider P, Wang J, Schwartz RJ, Moon AM, Conway SJ.

Dev Biol. 2011 Aug 15;356(2):308-22. doi: 10.1016/j.ydbio.2011.05.583. Epub 2011 May 12.

9.

Hypoxic stress in diabetic pregnancy contributes to impaired embryo gene expression and defective development by inducing oxidative stress.

Li R, Chase M, Jung SK, Smith PJ, Loeken MR.

Am J Physiol Endocrinol Metab. 2005 Oct;289(4):E591-9. Epub 2005 May 31.

10.
11.

Diabetes and apoptosis: neural crest cells and neural tube.

Chappell JH Jr, Wang XD, Loeken MR.

Apoptosis. 2009 Dec;14(12):1472-83. doi: 10.1007/s10495-009-0338-6. Review.

12.

Dual role for neural crest cells during outflow tract septation in the neural crest-deficient mutant Splotch(2H).

Bradshaw L, Chaudhry B, Hildreth V, Webb S, Henderson DJ.

J Anat. 2009 Feb;214(2):245-57. doi: 10.1111/j.1469-7580.2008.01028.x.

14.
15.

Lack of metformin effect on mouse embryo AMPK activity: implications for metformin treatment during pregnancy.

Lee HY, Wei D, Loeken MR.

Diabetes Metab Res Rev. 2014 Jan;30(1):23-30. doi: 10.1002/dmrr.2451.

17.

Transgenic rescue of congenital heart disease and spina bifida in Splotch mice.

Li J, Liu KC, Jin F, Lu MM, Epstein JA.

Development. 1999 Jun;126(11):2495-503.

18.

TGFβ and Wnt in cardiac outflow tract defects in offspring of diabetic pregnancies.

Zhao Z.

Birth Defects Res B Dev Reprod Toxicol. 2014 Oct;101(5):364-70. doi: 10.1002/bdrb.21120. Epub 2014 Sep 17.

19.

Current perspectives on the causes of neural tube defects resulting from diabetic pregnancy.

Loeken MR.

Am J Med Genet C Semin Med Genet. 2005 May 15;135C(1):77-87. Review.

PMID:
15800853
20.

Neural tube defects in embryos of diabetic mice: role of the Pax-3 gene and apoptosis.

Phelan SA, Ito M, Loeken MR.

Diabetes. 1997 Jul;46(7):1189-97.

PMID:
9200655

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