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Items: 1 to 20 of 107

1.

EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-alpha-induced pulmonary fibrosis.

Hardie WD, Davidson C, Ikegami M, Leikauf GD, Le Cras TD, Prestridge A, Whitsett JA, Korfhagen TR.

Am J Physiol Lung Cell Mol Physiol. 2008 Jun;294(6):L1217-25. doi: 10.1152/ajplung.00020.2008. Epub 2008 Apr 18.

2.

Rapamycin prevents transforming growth factor-alpha-induced pulmonary fibrosis.

Korfhagen TR, Le Cras TD, Davidson CR, Schmidt SM, Ikegami M, Whitsett JA, Hardie WD.

Am J Respir Cell Mol Biol. 2009 Nov;41(5):562-72. doi: 10.1165/rcmb.2008-0377OC. Epub 2009 Feb 24.

3.

Inhibition of the αvβ6 integrin leads to limited alteration of TGF-α-induced pulmonary fibrosis.

Madala SK, Korfhagen TR, Schmidt S, Davidson C, Edukulla R, Ikegami M, Violette SM, Weinreb PH, Sheppard D, Hardie WD.

Am J Physiol Lung Cell Mol Physiol. 2014 Apr 15;306(8):L726-35. doi: 10.1152/ajplung.00357.2013. Epub 2014 Feb 7.

4.

Conditional expression of transforming growth factor-alpha in adult mouse lung causes pulmonary fibrosis.

Hardie WD, Le Cras TD, Jiang K, Tichelaar JW, Azhar M, Korfhagen TR.

Am J Physiol Lung Cell Mol Physiol. 2004 Apr;286(4):L741-9. Epub 2003 Dec 5.

5.

Inhibition of PI3K by PX-866 prevents transforming growth factor-alpha-induced pulmonary fibrosis.

Le Cras TD, Korfhagen TR, Davidson C, Schmidt S, Fenchel M, Ikegami M, Whitsett JA, Hardie WD.

Am J Pathol. 2010 Feb;176(2):679-86. doi: 10.2353/ajpath.2010.090123. Epub 2009 Dec 30.

6.

Gefitinib attenuates murine pulmonary fibrosis induced by bleomycin.

Wang P, Tian Q, Liang ZX, Yang Z, Xu SF, Sun JP, Chen LA.

Chin Med J (Engl). 2010 Aug;123(16):2259-64.

PMID:
20819676
7.

Gefitinib prevents bleomycin-induced lung fibrosis in mice.

Ishii Y, Fujimoto S, Fukuda T.

Am J Respir Crit Care Med. 2006 Sep 1;174(5):550-6. Epub 2006 Jun 1.

PMID:
16741154
8.

Expression of epidermal growth factor (EGF)/transforming growth factor-alpha by human lung cancer cells determines their response to EGF receptor tyrosine kinase inhibition in the lungs of mice.

Wu W, O'Reilly MS, Langley RR, Tsan RZ, Baker CH, Bekele N, Tang XM, Onn A, Fidler IJ, Herbst RS.

Mol Cancer Ther. 2007 Oct;6(10):2652-63. Epub 2007 Oct 3.

9.

Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosis.

Hardie WD, Korfhagen TR, Sartor MA, Prestridge A, Medvedovic M, Le Cras TD, Ikegami M, Wesselkamper SC, Davidson C, Dietsch M, Nichols W, Whitsett JA, Leikauf GD.

Am J Respir Cell Mol Biol. 2007 Sep;37(3):309-21. Epub 2007 May 11.

10.
11.

MEK-ERK pathway modulation ameliorates pulmonary fibrosis associated with epidermal growth factor receptor activation.

Madala SK, Schmidt S, Davidson C, Ikegami M, Wert S, Hardie WD.

Am J Respir Cell Mol Biol. 2012 Mar;46(3):380-8. doi: 10.1165/rcmb.2011-0237OC. Epub 2011 Oct 20.

12.

Transforming growth factor-alpha deficiency reduces pulmonary fibrosis in transgenic mice.

Madtes DK, Elston AL, Hackman RC, Dunn AR, Clark JG.

Am J Respir Cell Mol Biol. 1999 May;20(5):924-34.

PMID:
10226062
13.

Transforming growth factor alpha expression drives constitutive epidermal growth factor receptor pathway activation and sensitivity to gefitinib (Iressa) in human pancreatic cancer cell lines.

Pino MS, Shrader M, Baker CH, Cognetti F, Xiong HQ, Abbruzzese JL, McConkey DJ.

Cancer Res. 2006 Apr 1;66(7):3802-12. Erratum in: Cancer Res. 2010 Jan 15;70(2):852-3.

14.

Early growth response-1 suppresses epidermal growth factor receptor-mediated airway hyperresponsiveness and lung remodeling in mice.

Kramer EL, Mushaben EM, Pastura PA, Acciani TH, Deutsch GH, Khurana Hershey GK, Korfhagen TR, Hardie WD, Whitsett JA, Le Cras TD.

Am J Respir Cell Mol Biol. 2009 Oct;41(4):415-25. doi: 10.1165/rcmb.2008-0470OC. Epub 2009 Feb 2.

15.

Dual-agent molecular targeting of the epidermal growth factor receptor (EGFR): combining anti-EGFR antibody with tyrosine kinase inhibitor.

Huang S, Armstrong EA, Benavente S, Chinnaiyan P, Harari PM.

Cancer Res. 2004 Aug 1;64(15):5355-62.

16.

Gefitinib and Erlotinib Lead to Phosphorylation of Eukaryotic Initiation Factor 2 Alpha Independent of Epidermal Growth Factor Receptor in A549 Cells.

Koyama S, Omura T, Yonezawa A, Imai S, Nakagawa S, Nakagawa T, Yano I, Matsubara K.

PLoS One. 2015 Aug 19;10(8):e0136176. doi: 10.1371/journal.pone.0136176. eCollection 2015.

17.

Epidermal growth factor receptor-tyrosine kinase inhibitor (gefitinib) augments pneumonitis, but attenuates lung fibrosis in response to radiation injury in rats.

Miyake K, Tani K, Kakiuchi S, Suzuka C, Toyoda Y, Kishi J, Tezuka T, Yuasa S, Hanibuchi M, Aono Y, Nishioka Y, Sone S.

J Med Invest. 2012;59(1-2):174-85.

18.
19.

[Gefitinib inhibits α-smooth muscle actin expression in mice with bleomycin-induced lung fibrosis].

Li L, Li WF, Cai L, Yuan WF, Huang WJ.

Nan Fang Yi Ke Da Xue Xue Bao. 2010 Dec;30(12):2675-8. Chinese.

20.

Suppression of expression of heat shock protein 70 by gefitinib and its contribution to pulmonary fibrosis.

Namba T, Tanaka K, Hoshino T, Azuma A, Mizushima T.

PLoS One. 2011;6(11):e27296. doi: 10.1371/journal.pone.0027296. Epub 2011 Nov 9.

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