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Unique and important consequences of RECQ1 deficiency in mammalian cells.

Sharma S, Brosh RM Jr.

Cell Cycle. 2008 Apr 15;7(8):989-1000. Epub 2008 Jan 30.


RECQ1 plays a distinct role in cellular response to oxidative DNA damage.

Sharma S, Phatak P, Stortchevoi A, Jasin M, Larocque JR.

DNA Repair (Amst). 2012 Jun 1;11(6):537-49. doi: 10.1016/j.dnarep.2012.04.003. Epub 2012 Apr 26.


Catalytic strand separation by RECQ1 is required for RPA-mediated response to replication stress.

Banerjee T, Sommers JA, Huang J, Seidman MM, Brosh RM Jr.

Curr Biol. 2015 Nov 2;25(21):2830-2838. doi: 10.1016/j.cub.2015.09.026. Epub 2015 Oct 8.


Human RECQ1 interacts with Ku70/80 and modulates DNA end-joining of double-strand breaks.

Parvathaneni S, Stortchevoi A, Sommers JA, Brosh RM Jr, Sharma S.

PLoS One. 2013 May 1;8(5):e62481. doi: 10.1371/journal.pone.0062481. Print 2013.


Distinct roles of RECQ1 in the maintenance of genomic stability.

Wu Y, Brosh RM Jr.

DNA Repair (Amst). 2010 Mar 2;9(3):315-24. doi: 10.1016/j.dnarep.2009.12.010. Epub 2010 Jan 12. Review.


RECQ1 possesses DNA branch migration activity.

Bugreev DV, Brosh RM Jr, Mazin AV.

J Biol Chem. 2008 Jul 18;283(29):20231-42. doi: 10.1074/jbc.M801582200. Epub 2008 May 21.


Probing Genome Maintenance Functions of human RECQ1.

Sami F, Sharma S.

Comput Struct Biotechnol J. 2013 Oct 18;6:e201303014. doi: 10.5936/csbj.201303014. eCollection 2013. Review.


Replication stress induces specific enrichment of RECQ1 at common fragile sites FRA3B and FRA16D.

Lu X, Parvathaneni S, Hara T, Lal A, Sharma S.

Mol Cancer. 2013 Apr 22;12(1):29. doi: 10.1186/1476-4598-12-29.


RECQL, a member of the RecQ family of DNA helicases, suppresses chromosomal instability.

Sharma S, Stumpo DJ, Balajee AS, Bock CB, Lansdorp PM, Brosh RM Jr, Blackshear PJ.

Mol Cell Biol. 2007 Mar;27(5):1784-94. Epub 2006 Dec 11.


Biochemical analysis of the DNA unwinding and strand annealing activities catalyzed by human RECQ1.

Sharma S, Sommers JA, Choudhary S, Faulkner JK, Cui S, Andreoli L, Muzzolini L, Vindigni A, Brosh RM Jr.

J Biol Chem. 2005 Jul 29;280(30):28072-84. Epub 2005 May 16.


Cellular deficiency of Werner syndrome protein or RECQ1 promotes genotoxic potential of hydroquinone and benzo[a]pyrene exposure.

Garige M, Sharma S.

Int J Toxicol. 2014 Sep-Oct;33(5):373-81. doi: 10.1177/1091581814547422. Epub 2014 Sep 15.


RECQ1 is required for cellular resistance to replication stress and catalyzes strand exchange on stalled replication fork structures.

Popuri V, Croteau DL, Brosh RM Jr, Bohr VA.

Cell Cycle. 2012 Nov 15;11(22):4252-65. doi: 10.4161/cc.22581. Epub 2012 Oct 24.


Roles of Werner syndrome protein in protection of genome integrity.

Rossi ML, Ghosh AK, Bohr VA.

DNA Repair (Amst). 2010 Mar 2;9(3):331-44. doi: 10.1016/j.dnarep.2009.12.011. Epub 2010 Jan 13. Review.


Human RecQL4 helicase plays multifaceted roles in the genomic stability of normal and cancer cells.

Mo D, Zhao Y, Balajee AS.

Cancer Lett. 2018 Jan 28;413:1-10. doi: 10.1016/j.canlet.2017.10.021. Epub 2017 Nov 7. Review.


The Human RecQ helicases, BLM and RECQ1, display distinct DNA substrate specificities.

Popuri V, Bachrati CZ, Muzzolini L, Mosedale G, Costantini S, Giacomini E, Hickson ID, Vindigni A.

J Biol Chem. 2008 Jun 27;283(26):17766-76. doi: 10.1074/jbc.M709749200. Epub 2008 Apr 30.


RECQ1 helicase interacts with human mismatch repair factors that regulate genetic recombination.

Doherty KM, Sharma S, Uzdilla LA, Wilson TM, Cui S, Vindigni A, Brosh RM Jr.

J Biol Chem. 2005 Jul 29;280(30):28085-94. Epub 2005 May 9.


Conserved helicase domain of human RecQ4 is required for strand annealing-independent DNA unwinding.

Rossi ML, Ghosh AK, Kulikowicz T, Croteau DL, Bohr VA.

DNA Repair (Amst). 2010 Jul 1;9(7):796-804. doi: 10.1016/j.dnarep.2010.04.003. Epub 2010 May 6.


RECQ1 interacts with FEN-1 and promotes binding of FEN-1 to telomeric chromatin.

Sami F, Lu X, Parvathaneni S, Roy R, Gary RK, Sharma S.

Biochem J. 2015 Jun 1;468(2):227-44. doi: 10.1042/BJ20141021.


The human RECQ1 helicase is highly expressed in glioblastoma and plays an important role in tumor cell proliferation.

Mendoza-Maldonado R, Faoro V, Bajpai S, Berti M, Odreman F, Vindigni M, Ius T, Ghasemian A, Bonin S, Skrap M, Stanta G, Vindigni A.

Mol Cancer. 2011 Jul 13;10:83. doi: 10.1186/1476-4598-10-83.

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