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A small-molecule furin inhibitor inhibits cancer cell motility and invasiveness.

Coppola JM, Bhojani MS, Ross BD, Rehemtulla A.

Neoplasia. 2008 Apr;10(4):363-70.


Inhibition of matrix metalloproteinase 2 maturation and HT1080 invasiveness by a synthetic furin inhibitor.

Maquoi E, Noël A, Frankenne F, Angliker H, Murphy G, Foidart JM.

FEBS Lett. 1998 Mar 13;424(3):262-6.


Regulation of matrix metalloproteinase MT1-MMP/MMP-2 in cardiac fibroblasts by TGF-beta1 involves furin-convertase.

Stawowy P, Margeta C, Kallisch H, Seidah NG, Chrétien M, Fleck E, Graf K.

Cardiovasc Res. 2004 Jul 1;63(1):87-97.


Prointegrin maturation follows rapid trafficking and processing of MT1-MMP in Furin-Negative Colon Carcinoma LoVo Cells.

Deryugina EI, Ratnikov BI, Yu Q, Baciu PC, Rozanov DV, Strongin AY.

Traffic. 2004 Aug;5(8):627-41.


Activation-coupled membrane-type 1 matrix metalloproteinase membrane trafficking.

Wu YI, Munshi HG, Snipas SJ, Salvesen GS, Fridman R, Stack MS.

Biochem J. 2007 Oct 15;407(2):171-7.


Inhibition of furin/proprotein convertase-catalyzed surface and intracellular processing by small molecules.

Komiyama T, Coppola JM, Larsen MJ, van Dort ME, Ross BD, Day R, Rehemtulla A, Fuller RS.

J Biol Chem. 2009 Jun 5;284(23):15729-38. doi: 10.1074/jbc.M901540200.


Role for furin in tumor necrosis factor alpha-induced activation of the matrix metalloproteinase/sphingolipid mitogenic pathway.

Tellier E, Nègre-Salvayre A, Bocquet B, Itohara S, Hannun YA, Salvayre R, Augé N.

Mol Cell Biol. 2007 Apr;27(8):2997-3007.


Furin-like proprotein convertases are central regulators of the membrane type matrix metalloproteinase-pro-matrix metalloproteinase-2 proteolytic cascade in atherosclerosis.

Stawowy P, Meyborg H, Stibenz D, Borges Pereira Stawowy N, Roser M, Thanabalasingam U, Veinot JP, Chrétien M, Seidah NG, Fleck E, Graf K.

Circulation. 2005 May 31;111(21):2820-7.


Integrin cleavage facilitates cell surface-associated proteolysis required for vascular smooth muscle cell invasion.

Kappert K, Meyborg H, Baumann B, Furundzija V, Kaufmann J, Graf K, Stibenz D, Fleck E, Stawowy P.

Int J Biochem Cell Biol. 2009 Jul;41(7):1511-7. doi: 10.1016/j.biocel.2009.01.004.


Golgi reassembly stacking protein 55 interacts with membrane-type (MT) 1-matrix metalloprotease (MMP) and furin and plays a role in the activation of the MT1-MMP zymogen.

Roghi C, Jones L, Gratian M, English WR, Murphy G.

FEBS J. 2010 Aug;277(15):3158-75. doi: 10.1111/j.1742-4658.2010.07723.x.


Opposing function of the proprotein convertases furin and PACE4 on breast cancer cells' malignant phenotypes: role of tissue inhibitors of metalloproteinase-1.

Lapierre M, Siegfried G, Scamuffa N, Bontemps Y, Calvo F, Seidah NG, Khatib AM.

Cancer Res. 2007 Oct 1;67(19):9030-4.


Furin is the major processing enzyme of the cardiac-specific growth factor bone morphogenetic protein 10.

Susan-Resiga D, Essalmani R, Hamelin J, Asselin MC, Benjannet S, Chamberland A, Day R, Szumska D, Constam D, Bhattacharya S, Prat A, Seidah NG.

J Biol Chem. 2011 Jul 1;286(26):22785-94. doi: 10.1074/jbc.M111.233577.


Internal cleavages of the autoinhibitory prodomain are required for membrane type 1 matrix metalloproteinase activation, although furin cleavage alone generates inactive proteinase.

Golubkov VS, Cieplak P, Chekanov AV, Ratnikov BI, Aleshin AE, Golubkova NV, Postnova TI, Radichev IA, Rozanov DV, Zhu W, Motamedchaboki K, Strongin AY.

J Biol Chem. 2010 Sep 3;285(36):27726-36. doi: 10.1074/jbc.M110.135442.

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