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Identification and functional analysis of phosphorylated tyrosine residues within EphA2 receptor tyrosine kinase.

Fang WB, Brantley-Sieders DM, Hwang Y, Ham AJ, Chen J.

J Biol Chem. 2008 Jun 6;283(23):16017-26. doi: 10.1074/jbc.M709934200. Epub 2008 Apr 3.


Essential role of Vav family guanine nucleotide exchange factors in EphA receptor-mediated angiogenesis.

Hunter SG, Zhuang G, Brantley-Sieders D, Swat W, Cowan CW, Chen J.

Mol Cell Biol. 2006 Jul;26(13):4830-42.


EphA2 receptor tyrosine kinase regulates endothelial cell migration and vascular assembly through phosphoinositide 3-kinase-mediated Rac1 GTPase activation.

Brantley-Sieders DM, Caughron J, Hicks D, Pozzi A, Ruiz JC, Chen J.

J Cell Sci. 2004 Apr 15;117(Pt 10):2037-49. Epub 2004 Mar 30.


Regulation of ephexin1, a guanine nucleotide exchange factor of Rho family GTPases, by fibroblast growth factor receptor-mediated tyrosine phosphorylation.

Zhang Y, Sawada T, Jing X, Yokote H, Yan X, Sakaguchi K.

J Biol Chem. 2007 Oct 19;282(42):31103-12. Epub 2007 Aug 16.


Regulation of EphA2 receptor endocytosis by SHIP2 lipid phosphatase via phosphatidylinositol 3-Kinase-dependent Rac1 activation.

Zhuang G, Hunter S, Hwang Y, Chen J.

J Biol Chem. 2007 Jan 26;282(4):2683-94. Epub 2006 Nov 29.


Vav3-rac1 signaling regulates prostate cancer metastasis with elevated Vav3 expression correlating with prostate cancer progression and posttreatment recurrence.

Lin KT, Gong J, Li CF, Jang TH, Chen WL, Chen HJ, Wang LH.

Cancer Res. 2012 Jun 15;72(12):3000-9. doi: 10.1158/0008-5472.CAN-11-2502. Epub 2012 Jun 1.


Biological and structural characterization of glycosylation on ephrin-A1, a preferred ligand for EphA2 receptor tyrosine kinase.

Ferluga S, Hantgan R, Goldgur Y, Himanen JP, Nikolov DB, Debinski W.

J Biol Chem. 2013 Jun 21;288(25):18448-57. doi: 10.1074/jbc.M113.464008. Epub 2013 May 9.


Impaired tumor microenvironment in EphA2-deficient mice inhibits tumor angiogenesis and metastatic progression.

Brantley-Sieders DM, Fang WB, Hicks DJ, Zhuang G, Shyr Y, Chen J.

FASEB J. 2005 Nov;19(13):1884-6. Epub 2005 Sep 15.


Promotion of cell spreading and migration by vascular endothelial-protein tyrosine phosphatase (VE-PTP) in cooperation with integrins.

Mori M, Murata Y, Kotani T, Kusakari S, Ohnishi H, Saito Y, Okazawa H, Ishizuka T, Mori M, Matozaki T.

J Cell Physiol. 2010 Jul;224(1):195-204. doi: 10.1002/jcp.22122.


The ephrin-A1 ligand and its receptor, EphA2, are expressed during tumor neovascularization.

Ogawa K, Pasqualini R, Lindberg RA, Kain R, Freeman AL, Pasquale EB.

Oncogene. 2000 Dec 7;19(52):6043-52.


p85 beta-PIX is required for cell motility through phosphorylations of focal adhesion kinase and p38 MAP kinase.

Lee J, Jung ID, Chang WK, Park CG, Cho DY, Shin EY, Seo DW, Kim YK, Lee HW, Han JW, Lee HY.

Exp Cell Res. 2005 Jul 15;307(2):315-28.


EphA2-induced angiogenesis in ewing sarcoma cells works through bFGF production and is dependent on caveolin-1.

Sáinz-Jaspeado M, Huertas-Martinez J, Lagares-Tena L, Martin Liberal J, Mateo-Lozano S, de Alava E, de Torres C, Mora J, Del Muro XG, Tirado OM.

PLoS One. 2013 Aug 12;8(8):e71449. doi: 10.1371/journal.pone.0071449. eCollection 2013.


Vav family proteins couple to diverse cell surface receptors.

Moores SL, Selfors LM, Fredericks J, Breit T, Fujikawa K, Alt FW, Brugge JS, Swat W.

Mol Cell Biol. 2000 Sep;20(17):6364-73.


EphA2 signaling following endocytosis: role of Tiam1.

Boissier P, Chen J, Huynh-Do U.

Traffic. 2013 Dec;14(12):1255-71. doi: 10.1111/tra.12123. Epub 2013 Oct 10.


Binding and function of phosphotyrosines of the Ephrin A2 (EphA2) receptor using synthetic sterile α motif (SAM) domains.

Borthakur S, Lee H, Kim S, Wang BC, Buck M.

J Biol Chem. 2014 Jul 11;289(28):19694-703. doi: 10.1074/jbc.M114.567602. Epub 2014 May 13.


Kinase-dependent and -independent roles of EphA2 in the regulation of prostate cancer invasion and metastasis.

Taddei ML, Parri M, Angelucci A, Onnis B, Bianchini F, Giannoni E, Raugei G, Calorini L, Rucci N, Teti A, Bologna M, Chiarugi P.

Am J Pathol. 2009 Apr;174(4):1492-503. doi: 10.2353/ajpath.2009.080473. Epub 2009 Mar 5.


Stimulus-dependent regulation of the phagocyte NADPH oxidase by a VAV1, Rac1, and PAK1 signaling axis.

Roepstorff K, Rasmussen I, Sawada M, Cudre-Maroux C, Salmon P, Bokoch G, van Deurs B, Vilhardt F.

J Biol Chem. 2008 Mar 21;283(12):7983-93. Epub 2007 Dec 26.


Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation.

Zeng L, Sachdev P, Yan L, Chan JL, Trenkle T, McClelland M, Welsh J, Wang LH.

Mol Cell Biol. 2000 Dec;20(24):9212-24.


Human cataract mutations in EPHA2 SAM domain alter receptor stability and function.

Park JE, Son AI, Hua R, Wang L, Zhang X, Zhou R.

PLoS One. 2012;7(5):e36564. doi: 10.1371/journal.pone.0036564. Epub 2012 May 3.

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