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Liver gene expression analysis reveals endoplasmic reticulum stress and metabolic dysfunction in SCD1-deficient mice fed a very low-fat diet.

Flowers MT, Keller MP, Choi Y, Lan H, Kendziorski C, Ntambi JM, Attie AD.

Physiol Genomics. 2008 May 13;33(3):361-72. doi: 10.1152/physiolgenomics.00139.2007.


Cholestasis and hypercholesterolemia in SCD1-deficient mice fed a low-fat, high-carbohydrate diet.

Flowers MT, Groen AK, Oler AT, Keller MP, Choi Y, Schueler KL, Richards OC, Lan H, Miyazaki M, Kuipers F, Kendziorski CM, Ntambi JM, Attie AD.

J Lipid Res. 2006 Dec;47(12):2668-80.


Reduced adiposity and liver steatosis by stearoyl-CoA desaturase deficiency are independent of peroxisome proliferator-activated receptor-alpha.

Miyazaki M, Dobrzyn A, Sampath H, Lee SH, Man WC, Chu K, Peters JM, Gonzalez FJ, Ntambi JM.

J Biol Chem. 2004 Aug 13;279(33):35017-24.


Individual stearoyl-coa desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivo.

Peter A, Weigert C, Staiger H, Machicao F, Schick F, Machann J, Stefan N, Thamer C, Häring HU, Schleicher E.

Diabetes. 2009 Aug;58(8):1757-65. doi: 10.2337/db09-0188.


Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis.

Miyazaki M, Flowers MT, Sampath H, Chu K, Otzelberger C, Liu X, Ntambi JM.

Cell Metab. 2007 Dec;6(6):484-96.


Metabolic changes in skin caused by Scd1 deficiency: a focus on retinol metabolism.

Flowers MT, Paton CM, O'Byrne SM, Schiesser K, Dawson JA, Blaner WS, Kendziorski C, Ntambi JM.

PLoS One. 2011 May 9;6(5):e19734. doi: 10.1371/journal.pone.0019734.


Hepatic knockdown of stearoyl-CoA desaturase 1 via RNA interference in obese mice decreases lipid content and changes fatty acid composition.

Xu H, Wilcox D, Nguyen P, Voorbach M, Smith H, Brodjian S, Suhar T, Reilly RM, Jacobson PB, Collins CA, Landschulz K, Surowy TK.

Front Biosci. 2007 May 1;12:3781-94.


Loss of stearoyl-CoA desaturase 1 inhibits fatty acid oxidation and increases glucose utilization in the heart.

Dobrzyn P, Sampath H, Dobrzyn A, Miyazaki M, Ntambi JM.

Am J Physiol Endocrinol Metab. 2008 Feb;294(2):E357-64.


Liver X receptor activation increases hepatic fatty acid desaturation by the induction of SCD1 expression through an LXRα-SREBP1c-dependent mechanism.

Zhang X, Liu J, Su W, Wu J, Wang C, Kong X, Gustafsson JÅ, Ding J, Ma X, Guan Y.

J Diabetes. 2014 May;6(3):212-20. doi: 10.1111/1753-0407.12081.


Peroxisome proliferators induce mouse liver stearoyl-CoA desaturase 1 gene expression.

Miller CW, Ntambi JM.

Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9443-8.


Stearoyl-CoA desaturase--a new player in skeletal muscle metabolism regulation.

Dobrzyń A, Dobrzyń P.

J Physiol Pharmacol. 2006 Nov;57 Suppl 10:31-42. Review.


Recent insights into stearoyl-CoA desaturase-1.

Ntambi JM, Miyazaki M.

Curr Opin Lipidol. 2003 Jun;14(3):255-61. Review.


Reduced levels of SCD1 accentuate palmitate-induced stress in insulin-producing β-cells.

Thörn K, Hovsepyan M, Bergsten P.

Lipids Health Dis. 2010 Sep 29;9:108. doi: 10.1186/1476-511X-9-108.


Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing beta-oxidation in skeletal muscle.

Dobrzyn A, Dobrzyn P, Lee SH, Miyazaki M, Cohen P, Asilmaz E, Hardie DG, Friedman JM, Ntambi JM.

Am J Physiol Endocrinol Metab. 2005 Mar;288(3):E599-607.


Modulation of palmitate-induced endoplasmic reticulum stress and apoptosis in pancreatic β-cells by stearoyl-CoA desaturase and Elovl6.

Green CD, Olson LK.

Am J Physiol Endocrinol Metab. 2011 Apr;300(4):E640-9. doi: 10.1152/ajpendo.00544.2010.


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