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Items: 1 to 20 of 74

1.

AMP-activated protein kinase is essential for survival in chronic hypoxia.

Borger DR, Gavrilescu LC, Bucur MC, Ivan M, Decaprio JA.

Biochem Biophys Res Commun. 2008 May 30;370(2):230-4. doi: 10.1016/j.bbrc.2008.03.056. Epub 2008 Mar 24.

2.
3.

Uveal melanoma cell growth is inhibited by aminoimidazole carboxamide ribonucleotide (AICAR) partially through activation of AMP-dependent kinase.

Al-Moujahed A, Nicolaou F, Brodowska K, Papakostas TD, Marmalidou A, Ksander BR, Miller JW, Gragoudas E, Vavvas DG.

Invest Ophthalmol Vis Sci. 2014 Apr 29;55(7):4175-85. doi: 10.1167/iovs.13-12856.

4.

The activation of the p53 pathway by the AMP mimetic AICAR is reduced by inhibitors of the ATM or mTOR kinases.

Zajkowicz A, Rusin M.

Mech Ageing Dev. 2011 Nov-Dec;132(11-12):543-51. doi: 10.1016/j.mad.2011.09.002. Epub 2011 Sep 21.

PMID:
21945951
5.

The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis.

Guo D, Hildebrandt IJ, Prins RM, Soto H, Mazzotta MM, Dang J, Czernin J, Shyy JY, Watson AD, Phelps M, Radu CG, Cloughesy TF, Mischel PS.

Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12932-7. doi: 10.1073/pnas.0906606106. Epub 2009 Jul 22.

6.

Regulation of the creatine transporter by AMP-activated protein kinase in kidney epithelial cells.

Li H, Thali RF, Smolak C, Gong F, Alzamora R, Wallimann T, Scholz R, Pastor-Soler NM, Neumann D, Hallows KR.

Am J Physiol Renal Physiol. 2010 Jul;299(1):F167-77. doi: 10.1152/ajprenal.00162.2010. Epub 2010 May 12.

7.

Stimulation of cardiomyogenesis of embryonic stem cells by nitric oxide downstream of AMP-activated protein kinase and mTOR signaling pathways.

Padmasekar M, Sharifpanah F, Finkensieper A, Wartenberg M, Sauer H.

Stem Cells Dev. 2011 Dec;20(12):2163-75. doi: 10.1089/scd.2010.0581. Epub 2011 Apr 6.

PMID:
21470048
8.

The effect of 5-aminoimidazole-4-carboxamide-ribonucleoside was mediated by p38 mitogen activated protein kinase signaling pathway in FRO thyroid cancer cells.

Kim WG, Choi HJ, Kim TY, Shong YK, Kim WB.

Korean J Intern Med. 2014 Jul;29(4):474-81. doi: 10.3904/kjim.2014.29.4.474. Epub 2014 Jun 27.

9.

Inhibition of glucocorticoid-induced apoptosis with 5-aminoimidazole-4-carboxamide ribonucleoside, a cell-permeable activator of AMP-activated protein kinase.

Stefanelli C, Stanic I, Bonavita F, Flamigni F, Pignatti C, Guarnieri C, Caldarera CM.

Biochem Biophys Res Commun. 1998 Feb 24;243(3):821-6.

PMID:
9500985
10.

The human glucagon-like peptide-1 analogue liraglutide regulates pancreatic beta-cell proliferation and apoptosis via an AMPK/mTOR/P70S6K signaling pathway.

Miao XY, Gu ZY, Liu P, Hu Y, Li L, Gong YP, Shu H, Liu Y, Li CL.

Peptides. 2013 Jan;39:71-9. doi: 10.1016/j.peptides.2012.10.006. Epub 2012 Oct 30.

PMID:
23116613
11.

Stimulation of glucose transport in response to activation of distinct AMPK signaling pathways.

Jing M, Cheruvu VK, Ismail-Beigi F.

Am J Physiol Cell Physiol. 2008 Nov;295(5):C1071-82. doi: 10.1152/ajpcell.00040.2008. Epub 2008 Aug 13.

12.

5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells?

Corton JM, Gillespie JG, Hawley SA, Hardie DG.

Eur J Biochem. 1995 Apr 15;229(2):558-65.

13.

Activation of AMP-kinase by AICAR induces apoptosis of DU-145 prostate cancer cells through generation of reactive oxygen species and activation of c-Jun N-terminal kinase.

Sauer H, Engel S, Milosevic N, Sharifpanah F, Wartenberg M.

Int J Oncol. 2012 Feb;40(2):501-8. doi: 10.3892/ijo.2011.1230. Epub 2011 Oct 13.

PMID:
22002081
14.

A pharmacological activator of AMP-activated protein kinase protects hypoxic neurons in a concentration-dependent manner.

Zhang X, Gao R, Li J, Qi Y, Song X, Zhao L, Wang H, Pu Y, Xu K, Li J.

Neurochem Res. 2010 Aug;35(8):1281-9. doi: 10.1007/s11064-010-0186-3. Epub 2010 May 20.

PMID:
20490918
15.

Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status.

Cheng SW, Fryer LG, Carling D, Shepherd PR.

J Biol Chem. 2004 Apr 16;279(16):15719-22. Epub 2004 Feb 17.

16.

Overexpression of CYP2E1 induces HepG2 cells death by the AMP kinase activator 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR).

Zhuge J.

Cell Biol Toxicol. 2009 Jun;25(3):253-63. doi: 10.1007/s10565-008-9075-9. Epub 2008 May 13.

PMID:
18473182
17.

AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling.

Bolster DR, Crozier SJ, Kimball SR, Jefferson LS.

J Biol Chem. 2002 Jul 5;277(27):23977-80. Epub 2002 May 7.

19.

Activation of adenosine monophosphate activated protein kinase inhibits growth of multiple myeloma cells.

Baumann P, Mandl-Weber S, Emmerich B, Straka C, Schmidmaier R.

Exp Cell Res. 2007 Oct 1;313(16):3592-603. Epub 2007 Jul 4.

PMID:
17669398
20.

A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway.

Kimura N, Tokunaga C, Dalal S, Richardson C, Yoshino K, Hara K, Kemp BE, Witters LA, Mimura O, Yonezawa K.

Genes Cells. 2003 Jan;8(1):65-79.

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