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Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways.

Jacobs SR, Herman CE, Maciver NJ, Wofford JA, Wieman HL, Hammen JJ, Rathmell JC.

J Immunol. 2008 Apr 1;180(7):4476-86.


Evidence implicating the Ras pathway in multiple CD28 costimulatory functions in CD4+ T cells.

Janardhan SV, Praveen K, Marks R, Gajewski TF.

PLoS One. 2011;6(9):e24931. doi: 10.1371/journal.pone.0024931. Epub 2011 Sep 19.


IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival.

Wofford JA, Wieman HL, Jacobs SR, Zhao Y, Rathmell JC.

Blood. 2008 Feb 15;111(4):2101-11. Epub 2007 Nov 27.


Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking.

Wieman HL, Wofford JA, Rathmell JC.

Mol Biol Cell. 2007 Apr;18(4):1437-46. Epub 2007 Feb 14.


WASH knockout T cells demonstrate defective receptor trafficking, proliferation, and effector function.

Piotrowski JT, Gomez TS, Schoon RA, Mangalam AK, Billadeau DD.

Mol Cell Biol. 2013 Mar;33(5):958-73. doi: 10.1128/MCB.01288-12. Epub 2012 Dec 28.


Cutting edge: distinct motifs within CD28 regulate T cell proliferation and induction of Bcl-XL.

Burr JS, Savage ND, Messah GE, Kimzey SL, Shaw AS, Arch RH, Green JM.

J Immunol. 2001 May 1;166(9):5331-5.


Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival.

Maciver NJ, Jacobs SR, Wieman HL, Wofford JA, Coloff JL, Rathmell JC.

J Leukoc Biol. 2008 Oct;84(4):949-57. doi: 10.1189/jlb.0108024. Epub 2008 Jun 24. Review.


γδ T cells acquire effector fates in the thymus and differentiate into cytokine-producing effectors in a Listeria model of infection independently of CD28 costimulation.

Laird RM, Wolf BJ, Princiotta MF, Hayes SM.

PLoS One. 2013 May 9;8(5):e63178. doi: 10.1371/journal.pone.0063178. Print 2013.


CD28 costimulation promotes the production of Th2 cytokines.

Rulifson IC, Sperling AI, Fields PE, Fitch FW, Bluestone JA.

J Immunol. 1997 Jan 15;158(2):658-65.


Suppression of Glut1 and Glucose Metabolism by Decreased Akt/mTORC1 Signaling Drives T Cell Impairment in B Cell Leukemia.

Siska PJ, van der Windt GJ, Kishton RJ, Cohen S, Eisner W, MacIver NJ, Kater AP, Weinberg JB, Rathmell JC.

J Immunol. 2016 Sep 15;197(6):2532-40. doi: 10.4049/jimmunol.1502464. Epub 2016 Aug 10.


CD28 signaling in primary CD4(+) T cells: identification of both tyrosine phosphorylation-dependent and phosphorylation-independent pathways.

Ogawa S, Watanabe M, Sakurai Y, Inutake Y, Watanabe S, Tai X, Abe R.

Int Immunol. 2013 Dec;25(12):671-81. doi: 10.1093/intimm/dxt028. Epub 2013 Sep 18.


Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival.

Rathmell JC, Fox CJ, Plas DR, Hammerman PS, Cinalli RM, Thompson CB.

Mol Cell Biol. 2003 Oct;23(20):7315-28.


Conditional deletion of PTEN in peripheral T cells augments TCR-mediated activation but does not abrogate CD28 dependency or prevent anergy induction.

Locke FL, Zha YY, Zheng Y, Driessens G, Gajewski TF.

J Immunol. 2013 Aug 15;191(4):1677-85. doi: 10.4049/jimmunol.1202018. Epub 2013 Jul 12.


Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells.

Caro-Maldonado A, Wang R, Nichols AG, Kuraoka M, Milasta S, Sun LD, Gavin AL, Abel ED, Kelsoe G, Green DR, Rathmell JC.

J Immunol. 2014 Apr 15;192(8):3626-36. doi: 10.4049/jimmunol.1302062. Epub 2014 Mar 10.


The CD28 signaling pathway regulates glucose metabolism.

Frauwirth KA, Riley JL, Harris MH, Parry RV, Rathmell JC, Plas DR, Elstrom RL, June CH, Thompson CB.

Immunity. 2002 Jun;16(6):769-77.


A CD28-associated signaling pathway leading to cytokine gene transcription and T cell proliferation without TCR engagement.

Siefken R, Klein-Hessling S, Serfling E, Kurrle R, Schwinzer R.

J Immunol. 1998 Aug 15;161(4):1645-51.

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