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Items: 1 to 20 of 212

1.

Stimulation of human and rat islet beta-cell proliferation with retention of function by the homeodomain transcription factor Nkx6.1.

Schisler JC, Fueger PT, Babu DA, Hohmeier HE, Tessem JS, Lu D, Becker TC, Naziruddin B, Levy M, Mirmira RG, Newgard CB.

Mol Cell Biol. 2008 May;28(10):3465-76. doi: 10.1128/MCB.01791-07. Epub 2008 Mar 17.

2.

Overexpression of pre-pro-cholecystokinin stimulates beta-cell proliferation in mouse and human islets with retention of islet function.

Lavine JA, Raess PW, Davis DB, Rabaglia ME, Presley BK, Keller MP, Beinfeld MC, Kopin AS, Newgard CB, Attie AD.

Mol Endocrinol. 2008 Dec;22(12):2716-28. doi: 10.1210/me.2008-0255. Epub 2008 Oct 9. Retraction in: Mol Endocrinol. 2010 Feb;24(2):472.

3.

The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells.

Schisler JC, Jensen PB, Taylor DG, Becker TC, Knop FK, Takekawa S, German M, Weir GC, Lu D, Mirmira RG, Newgard CB.

Proc Natl Acad Sci U S A. 2005 May 17;102(20):7297-302. Epub 2005 May 9.

4.

Pdx-1 activates islet α- and β-cell proliferation via a mechanism regulated by transient receptor potential cation channels 3 and 6 and extracellular signal-regulated kinases 1 and 2.

Hayes HL, Moss LG, Schisler JC, Haldeman JM, Zhang Z, Rosenberg PB, Newgard CB, Hohmeier HE.

Mol Cell Biol. 2013 Oct;33(20):4017-29. doi: 10.1128/MCB.00469-13. Epub 2013 Aug 12.

5.

Aurora Kinase A is critical for the Nkx6.1 mediated β-cell proliferation pathway.

Hobson A, Draney C, Stratford A, Becker TC, Lu D, Arlotto M, Tessem JS.

Islets. 2015;7(1):e1027854. doi: 10.1080/19382014.2015.1027854. Epub 2015 Jun 1.

6.

Distinct regulation of hepatic nuclear factor 1alpha by NKX6.1 in pancreatic beta cells.

Donelan W, Koya V, Li SW, Yang LJ.

J Biol Chem. 2010 Apr 16;285(16):12181-9. doi: 10.1074/jbc.M109.064238. Epub 2010 Jan 27.

7.

Exendin-4 stimulation of cyclin A2 in beta-cell proliferation.

Song WJ, Schreiber WE, Zhong E, Liu FF, Kornfeld BD, Wondisford FE, Hussain MA.

Diabetes. 2008 Sep;57(9):2371-81. doi: 10.2337/db07-1541. Epub 2008 Jun 10.

8.

The diabetes-linked transcription factor Pax4 is expressed in human pancreatic islets and is activated by mitogens and GLP-1.

Brun T, Hu He KH, Lupi R, Boehm B, Wojtusciszyn A, Sauter N, Donath M, Marchetti P, Maedler K, Gauthier BR.

Hum Mol Genet. 2008 Feb 15;17(4):478-89. Epub 2007 Nov 7.

PMID:
17989064
9.

Cdk5r1 Overexpression Induces Primary β-Cell Proliferation.

Draney C, Hobson AE, Grover SG, Jack BO, Tessem JS.

J Diabetes Res. 2016;2016:6375804. doi: 10.1155/2016/6375804. Epub 2015 Dec 14.

10.

Nkx6.1 regulates islet β-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors.

Tessem JS, Moss LG, Chao LC, Arlotto M, Lu D, Jensen MV, Stephens SB, Tontonoz P, Hohmeier HE, Newgard CB.

Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5242-7. doi: 10.1073/pnas.1320953111. Epub 2014 Mar 24.

11.

Transgenic overexpression of the transcription factor Nkx6.1 in β-cells of mice does not increase β-cell proliferation, β-cell mass, or improve glucose clearance.

Schaffer AE, Yang AJ, Thorel F, Herrera PL, Sander M.

Mol Endocrinol. 2011 Nov;25(11):1904-14. doi: 10.1210/me.2011-1139. Epub 2011 Sep 29.

13.

Reprogramming of enteroendocrine K cells to pancreatic β-cells through the combined expression of Nkx6.1 and Neurogenin3, and reaggregation in suspension culture.

Lee E, Ryu GR, Moon SD, Ko SH, Ahn YB, Song KH.

Biochem Biophys Res Commun. 2014 Jan 17;443(3):1021-7. doi: 10.1016/j.bbrc.2013.12.093. Epub 2013 Dec 21.

PMID:
24365150
14.

A VGF-derived peptide attenuates development of type 2 diabetes via enhancement of islet β-cell survival and function.

Stephens SB, Schisler JC, Hohmeier HE, An J, Sun AY, Pitt GS, Newgard CB.

Cell Metab. 2012 Jul 3;16(1):33-43. doi: 10.1016/j.cmet.2012.05.011.

15.

Effects of islet neogenesis-associated protein pentadecapeptide on cell mass and insulin secretion of pancreatic β-cells.

Zha M, Zhang M, Shan S, Xu KF, Chen H, Xu XY, Qian L, Han X, Yang T.

J Endocrinol Invest. 2012 Jul;35(7):634-9. doi: 10.3275/7922. Epub 2011 Sep 23.

PMID:
21945952
16.

Atrial natriuretic peptide promotes pancreatic islet beta-cell growth and Akt/Foxo1a/cyclin D2 signaling.

You H, Laychock SG.

Endocrinology. 2009 Dec;150(12):5455-65. doi: 10.1210/en.2009-0468. Epub 2009 Oct 16.

PMID:
19837876
17.
18.

Transduction of exogenous constitutively activated Stat3 into dispersed islets induces proliferation of rat pancreatic beta-cells.

Tsukiyama S, Matsushita M, Matsumoto S, Morita T, Kobayashi S, Tamura H, Kamachi H, Ozaki M, Todo S.

Tissue Eng. 2006 Jan;12(1):131-40.

PMID:
16499450
20.

Trefoil factor 3 stimulates human and rodent pancreatic islet beta-cell replication with retention of function.

Fueger PT, Schisler JC, Lu D, Babu DA, Mirmira RG, Newgard CB, Hohmeier HE.

Mol Endocrinol. 2008 May;22(5):1251-9. doi: 10.1210/me.2007-0500. Epub 2008 Feb 7.

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