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Items: 1 to 20 of 91

1.

Pyruvate kinase M2 is a phosphotyrosine-binding protein.

Christofk HR, Vander Heiden MG, Wu N, Asara JM, Cantley LC.

Nature. 2008 Mar 13;452(7184):181-6. doi: 10.1038/nature06667.

PMID:
18337815
2.

Reciprocal regulation of protein kinase and pyruvate kinase activities of pyruvate kinase M2 by growth signals.

Gao X, Wang H, Yang JJ, Chen J, Jie J, Li L, Zhang Y, Liu ZR.

J Biol Chem. 2013 May 31;288(22):15971-9. doi: 10.1074/jbc.M112.448753. Epub 2013 Apr 10.

3.

MUC1-C oncoprotein regulates glycolysis and pyruvate kinase M2 activity in cancer cells.

Kosugi M, Ahmad R, Alam M, Uchida Y, Kufe D.

PLoS One. 2011;6(11):e28234. doi: 10.1371/journal.pone.0028234. Epub 2011 Nov 28.

4.

Pyruvate kinase M2 affects liver cancer cell behavior through up-regulation of HIF-1α and Bcl-xL in culture.

Dong T, Yan Y, Chai H, Chen S, Xiong X, Sun D, Yu Y, Deng L, Cheng F.

Biomed Pharmacother. 2015 Feb;69:277-84. doi: 10.1016/j.biopha.2014.12.010. Epub 2014 Dec 19.

PMID:
25661370
5.

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.

Anastasiou D, Yu Y, Israelsen WJ, Jiang JK, Boxer MB, Hong BS, Tempel W, Dimov S, Shen M, Jha A, Yang H, Mattaini KR, Metallo CM, Fiske BP, Courtney KD, Malstrom S, Khan TM, Kung C, Skoumbourdis AP, Veith H, Southall N, Walsh MJ, Brimacombe KR, Leister W, Lunt SY, Johnson ZR, Yen KE, Kunii K, Davidson SM, Christofk HR, Austin CP, Inglese J, Harris MH, Asara JM, Stephanopoulos G, Salituro FG, Jin S, Dang L, Auld DS, Park HW, Cantley LC, Thomas CJ, Vander Heiden MG.

Nat Chem Biol. 2012 Oct;8(10):839-47. Erratum in: Nat Chem Biol. 2012 Dec;8(12):1008.

6.

Protein tyrosine phosphatase 1B regulates pyruvate kinase M2 tyrosine phosphorylation.

Bettaieb A, Bakke J, Nagata N, Matsuo K, Xi Y, Liu S, AbouBechara D, Melhem R, Stanhope K, Cummings B, Graham J, Bremer A, Zhang S, Lyssiotis CA, Zhang ZY, Cantley LC, Havel PJ, Haj FG.

J Biol Chem. 2013 Jun 14;288(24):17360-71. doi: 10.1074/jbc.M112.441469. Epub 2013 May 2.

7.

Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth.

Hitosugi T, Kang S, Vander Heiden MG, Chung TW, Elf S, Lythgoe K, Dong S, Lonial S, Wang X, Chen GZ, Xie J, Gu TL, Polakiewicz RD, Roesel JL, Boggon TJ, Khuri FR, Gilliland DG, Cantley LC, Kaufman J, Chen J.

Sci Signal. 2009 Nov 17;2(97):ra73. doi: 10.1126/scisignal.2000431.

8.

Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells.

Mazurek S.

Int J Biochem Cell Biol. 2011 Jul;43(7):969-80. doi: 10.1016/j.biocel.2010.02.005. Epub 2010 Feb 13. Review.

PMID:
20156581
9.

Evidence for an alternative glycolytic pathway in rapidly proliferating cells.

Vander Heiden MG, Locasale JW, Swanson KD, Sharfi H, Heffron GJ, Amador-Noguez D, Christofk HR, Wagner G, Rabinowitz JD, Asara JM, Cantley LC.

Science. 2010 Sep 17;329(5998):1492-9. doi: 10.1126/science.1188015.

10.

Death-associated protein kinase increases glycolytic rate through binding and activation of pyruvate kinase.

Mor I, Carlessi R, Ast T, Feinstein E, Kimchi A.

Oncogene. 2012 Feb 9;31(6):683-93. doi: 10.1038/onc.2011.264. Epub 2011 Jul 4.

PMID:
21725354
11.

Pyruvate kinase M2: multiple faces for conferring benefits on cancer cells.

Tamada M, Suematsu M, Saya H.

Clin Cancer Res. 2012 Oct 15;18(20):5554-61. doi: 10.1158/1078-0432.CCR-12-0859. Review.

12.

Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis.

Dombrauckas JD, Santarsiero BD, Mesecar AD.

Biochemistry. 2005 Jul 12;44(27):9417-29.

PMID:
15996096
13.

HSP40 interacts with pyruvate kinase M2 and regulates glycolysis and cell proliferation in tumor cells.

Huang L, Yu Z, Zhang T, Zhao X, Huang G.

PLoS One. 2014 Mar 21;9(3):e92949. doi: 10.1371/journal.pone.0092949. eCollection 2014.

14.

Pyruvate kinase: Function, regulation and role in cancer.

Israelsen WJ, Vander Heiden MG.

Semin Cell Dev Biol. 2015 Jul;43:43-51. doi: 10.1016/j.semcdb.2015.08.004. Epub 2015 Aug 13. Review.

15.

Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase.

Gao X, Wang H, Yang JJ, Liu X, Liu ZR.

Mol Cell. 2012 Mar 9;45(5):598-609. doi: 10.1016/j.molcel.2012.01.001. Epub 2012 Feb 2.

16.

Identification of small molecule inhibitors of pyruvate kinase M2.

Vander Heiden MG, Christofk HR, Schuman E, Subtelny AO, Sharfi H, Harlow EE, Xian J, Cantley LC.

Biochem Pharmacol. 2010 Apr 15;79(8):1118-24. doi: 10.1016/j.bcp.2009.12.003. Epub 2009 Dec 11.

17.

Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation.

Ye J, Mancuso A, Tong X, Ward PS, Fan J, Rabinowitz JD, Thompson CB.

Proc Natl Acad Sci U S A. 2012 May 1;109(18):6904-9. doi: 10.1073/pnas.1204176109. Epub 2012 Apr 16.

18.
19.

Apigenin Restrains Colon Cancer Cell Proliferation via Targeted Blocking of Pyruvate Kinase M2-Dependent Glycolysis.

Shan S, Shi J, Yang P, Jia B, Wu H, Zhang X, Li Z.

J Agric Food Chem. 2017 Sep 20;65(37):8136-8144. doi: 10.1021/acs.jafc.7b02757. Epub 2017 Sep 11.

PMID:
28829588
20.

A novel pyruvate kinase M2 activator compound that suppresses lung cancer cell viability under hypoxia.

Kim DJ, Park YS, Kim ND, Min SH, You YM, Jung Y, Koo H, Noh H, Kim JA, Park KC, Yeom YI.

Mol Cells. 2015 Apr;38(4):373-9. doi: 10.14348/molcells.2015.2314. Epub 2015 Mar 26.

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