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A mechanism for Ikaros regulation of human globin gene switching.

Keys JR, Tallack MR, Zhan Y, Papathanasiou P, Goodnow CC, Gaensler KM, Crossley M, Dekker J, Perkins AC.

Br J Haematol. 2008 May;141(3):398-406. doi: 10.1111/j.1365-2141.2008.07065.x. Epub 2008 Mar 3.


Role of intergenic human gamma-delta-globin sequences in human hemoglobin switching and reactivation of fetal hemoglobin in adult erythroid cells.

Bank A, O'Neill D, Lopez R, Pulte D, Ward M, Mantha S, Richardson C.

Ann N Y Acad Sci. 2005;1054:48-54. Review.


Developmental regulation of human gamma- and beta-globin genes in the absence of the locus control region.

Starck J, Sarkar R, Romana M, Bhargava A, Scarpa AL, Tanaka M, Chamberlain JW, Weissman SM, Forget BG.

Blood. 1994 Sep 1;84(5):1656-65.


Juxtaposition of the HPFH2 enhancer is not sufficient to reactivate the gamma-globin gene in adult erythropoiesis.

Xiang P, Han H, Barkess G, Olave I, Fang X, Yin W, Stamatoyannopoulos G, Li Q.

Hum Mol Genet. 2005 Oct 15;14(20):3047-56. Epub 2005 Sep 9.


Evidence for a bigenic chromatin subdomain in regulation of the fetal-to-adult hemoglobin switch.

Beauchemin H, Trudel M.

Mol Cell Biol. 2009 Mar;29(6):1635-48. doi: 10.1128/MCB.01735-08. Epub 2008 Dec 29.


Multiplex ligation-dependent probe amplification screening of isolated increased HbF levels revealed three cases of novel rearrangements/deletions in the beta-globin gene cluster.

Lee ST, Yoo EH, Kim JY, Kim JW, Ki CS.

Br J Haematol. 2010 Jan;148(1):154-60. doi: 10.1111/j.1365-2141.2009.07927.x. Epub 2009 Oct 5.


An ikaros-containing chromatin-remodeling complex in adult-type erythroid cells.

O'Neill DW, Schoetz SS, Lopez RA, Castle M, Rabinowitz L, Shor E, Krawchuk D, Goll MG, Renz M, Seelig HP, Han S, Seong RH, Park SD, Agalioti T, Munshi N, Thanos D, Erdjument-Bromage H, Tempst P, Bank A.

Mol Cell Biol. 2000 Oct;20(20):7572-82.


[Ikaros and erythropoiesis].

Dijon M, Chabannon C, Tonnelle C.

Med Sci (Paris). 2008 Dec;24(12):1065-70. doi: 10.1051/medsci/200824121065. French.


Use of yeast artificial chromosomes (YACs) in studies of mammalian development: production of beta-globin locus YAC mice carrying human globin developmental mutants.

Peterson KR, Li QL, Clegg CH, Furukawa T, Navas PA, Norton EJ, Kimbrough TG, Stamatoyannopoulos G.

Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5655-9.


Sequences located 3' to the breakpoint of the hereditary persistence of fetal hemoglobin-3 deletion exhibit enhancer activity and can modify the developmental expression of the human fetal A gamma-globin gene in transgenic mice.

Anagnou NP, Perez-Stable C, Gelinas R, Costantini F, Liapaki K, Constantopoulou M, Kosteas T, Moschonas NK, Stamatoyannopoulos G.

J Biol Chem. 1995 Apr 28;270(17):10256-63.


Persistent gamma-globin expression in adult transgenic mice is mediated by HPFH-2, HPFH-3, and HPFH-6 breakpoint sequences.

Katsantoni EZ, Langeveld A, Wai AW, Drabek D, Grosveld F, Anagnou NP, Strouboulis J.

Blood. 2003 Nov 1;102(9):3412-9. Epub 2003 Jul 10.


Ikaros and GATA-1 combinatorial effect is required for silencing of human gamma-globin genes.

Bottardi S, Ross J, Bourgoin V, Fotouhi-Ardakani N, Affar el B, Trudel M, Milot E.

Mol Cell Biol. 2009 Mar;29(6):1526-37. doi: 10.1128/MCB.01523-08. Epub 2008 Dec 29.


Human fetal-to-adult globin gene switching in transgenic mice: persistent expression of the G gamma-globin gene in the Japanese HPFH.

Katsube T, Tojo H, Sakaguchi T, Fukumaki Y.

Biochem Biophys Res Commun. 1993 Jul 15;194(1):246-52.


Identification of novel candidate genes for globin regulation in erythroid cells containing large deletions of the human beta-globin gene cluster.

de Andrade TG, Peterson KR, Cunha AF, Moreira LS, Fattori A, Saad ST, Costa FF.

Blood Cells Mol Dis. 2006 Sep-Oct;37(2):82-90. Epub 2006 Sep 6.


Multiple hematopoietic defects and delayed globin switching in Ikaros null mice.

Lopez RA, Schoetz S, DeAngelis K, O'Neill D, Bank A.

Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):602-7.


Eos negatively regulates human γ-globin gene transcription during erythroid differentiation.

Yu HC, Zhao HL, Wu ZK, Zhang JW.

PLoS One. 2011;6(7):e22907. doi: 10.1371/journal.pone.0022907. Epub 2011 Jul 28.


Tissue-specific and developmental stage-specific DNA binding by a mammalian SWI/SNF complex associated with human fetal-to-adult globin gene switching.

O'Neill D, Yang J, Erdjument-Bromage H, Bornschlegel K, Tempst P, Bank A.

Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):349-54.


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