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Additive effect of AAV-mediated angiopoietin-1 and VEGF expression on the therapy of infarcted heart.

Su H, Takagawa J, Huang Y, Arakawa-Hoyt J, Pons J, Grossman W, Kan YW.

Int J Cardiol. 2009 Apr 3;133(2):191-7. doi: 10.1016/j.ijcard.2007.12.034. Epub 2008 Mar 4.


Coexpression of angiopoietin-1 with VEGF increases the structural integrity of the blood-brain barrier and reduces atrophy volume.

Shen F, Walker EJ, Jiang L, Degos V, Li J, Sun B, Heriyanto F, Young WL, Su H.

J Cereb Blood Flow Metab. 2011 Dec;31(12):2343-51. doi: 10.1038/jcbfm.2011.97. Epub 2011 Jul 20.


Depressed expression of angiogenic growth factors in the subacute phase of myocardial ischemia: a mechanism behind the remodeling plateau?

Siddiqui AJ, Fischer H, Widegren U, Grinnemo KH, Hao X, Månsson-Broberg A, Sylvén C, Gustafsson T.

Coron Artery Dis. 2010 Mar;21(2):65-71. doi: 10.1097/MCA.0b013e3283349cbb.


Adeno-associated viral vector delivers cardiac-specific and hypoxia-inducible VEGF expression in ischemic mouse hearts.

Su H, Joho S, Huang Y, Barcena A, Arakawa-Hoyt J, Grossman W, Kan YW.

Proc Natl Acad Sci U S A. 2004 Nov 16;101(46):16280-5. Epub 2004 Nov 8.


Structural stability of neoangiogenic intramyocardial microvessels supports functional recovery in chronic ischemic myocardium.

Shim WS, Lim SY, Li SQ, Gu Y, Ong HC, Song IC, Chuah SC, Wong P.

J Mol Cell Cardiol. 2008 Jul;45(1):70-80. doi: 10.1016/j.yjmcc.2008.04.007. Epub 2008 Apr 27.


AAV serotype-1 mediates early onset of gene expression in mouse hearts and results in better therapeutic effect.

Su H, Huang Y, Takagawa J, Barcena A, Arakawa-Hoyt J, Ye J, Grossman W, Kan YW.

Gene Ther. 2006 Nov;13(21):1495-502. Epub 2006 Jun 15.


Critical role of angiopoietins/Tie-2 in hyperglycemic exacerbation of myocardial infarction and impaired angiogenesis.

Tuo QH, Zeng H, Stinnett A, Yu H, Aschner JL, Liao DF, Chen JX.

Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2547-57. doi: 10.1152/ajpheart.01250.2007. Epub 2008 Apr 11.


Coexpression of VEGF and angiopoietin-1 promotes angiogenesis and cardiomyocyte proliferation reduces apoptosis in porcine myocardial infarction (MI) heart.

Tao Z, Chen B, Tan X, Zhao Y, Wang L, Zhu T, Cao K, Yang Z, Kan YW, Su H.

Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2064-9. doi: 10.1073/pnas.1018925108. Epub 2011 Jan 18.


Combination of angiopoietin-1 and vascular endothelial growth factor gene therapy enhances arteriogenesis in the ischemic myocardium.

Siddiqui AJ, Blomberg P, Wärdell E, Hellgren I, Eskandarpour M, Islam KB, Sylvén C.

Biochem Biophys Res Commun. 2003 Oct 24;310(3):1002-9.


[Angiogenesis in chronic ischemic porcine myocardium after transfer of VEGF₁₆₅ and angiopoietin-1 mediated by recombinant adeno-associated viral vector].

Zhu CC, Chen SL, Liu YQ, Tang LJ, Lin XF, Bao WG, Ma DH, Zhu GQ, Zhou WJ, Zhou YL, Du CW.

Zhejiang Da Xue Xue Bao Yi Xue Ban. 2010 Nov;39(6):610-7. Chinese.


Combining angiogenic gene and stem cell therapies for myocardial infarction.

Pons J, Huang Y, Takagawa J, Arakawa-Hoyt J, Ye J, Grossman W, Kan YW, Su H.

J Gene Med. 2009 Sep;11(9):743-53. doi: 10.1002/jgm.1362.


Combined cord blood stem cells and gene therapy enhances angiogenesis and improves cardiac performance in mouse after acute myocardial infarction.

Chen HK, Hung HF, Shyu KG, Wang BW, Sheu JR, Liang YJ, Chang CC, Kuan P.

Eur J Clin Invest. 2005 Nov;35(11):677-86.


Sustained expression of vascular endothelial growth factor and angiopoietin-1 improves blood-spinal cord barrier integrity and functional recovery after spinal cord injury.

Herrera JJ, Sundberg LM, Zentilin L, Giacca M, Narayana PA.

J Neurotrauma. 2010 Nov;27(11):2067-76. doi: 10.1089/neu.2010.1403. Epub 2010 Oct 28.


Ultrasound-targeted gene delivery induces angiogenesis after a myocardial infarction in mice.

Fujii H, Sun Z, Li SH, Wu J, Fazel S, Weisel RD, Rakowski H, Lindner J, Li RK.

JACC Cardiovasc Imaging. 2009 Jul;2(7):869-79. doi: 10.1016/j.jcmg.2009.04.008.


Sequential, timely and controlled expression of hVEGF165 and Ang-1 effectively improves functional angiogenesis and cardiac function in vivo.

Zhang H, Yuan YL, Wang Z, Jiang B, Zhang CS, Wang Q, Xu XH, Dong HY, Zhang ZM.

Gene Ther. 2013 Sep;20(9):893-900. doi: 10.1038/gt.2013.12. Epub 2013 Mar 21.


AAV serotype 1 mediates more efficient gene transfer to pig myocardium than AAV serotype 2 and plasmid.

Su H, Yeghiazarians Y, Lee A, Huang Y, Arakawa-Hoyt J, Ye J, Orcino G, Grossman W, Kan YW.

J Gene Med. 2008 Jan;10(1):33-41.


Combination of VEGF(165)/Angiopoietin-1 gene and endothelial progenitor cells for therapeutic neovascularization.

Chen F, Tan Z, Dong CY, Li X, Xie Y, Wu Y, Chen X, Guo S.

Eur J Pharmacol. 2007 Jul 30;568(1-3):222-30. Epub 2007 May 10.


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