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Items: 1 to 20 of 108

1.

How force might activate talin's vinculin binding sites: SMD reveals a structural mechanism.

Hytönen VP, Vogel V.

PLoS Comput Biol. 2008 Feb;4(2):e24. doi: 10.1371/journal.pcbi.0040024.

2.

Molecular dynamics study of talin-vinculin binding.

Lee SE, Chunsrivirot S, Kamm RD, Mofrad MR.

Biophys J. 2008 Aug;95(4):2027-36. doi: 10.1529/biophysj.107.124487. Epub 2008 Apr 11.

3.

Stretching single talin rod molecules activates vinculin binding.

del Rio A, Perez-Jimenez R, Liu R, Roca-Cusachs P, Fernandez JM, Sheetz MP.

Science. 2009 Jan 30;323(5914):638-41. doi: 10.1126/science.1162912.

4.

A vinculin binding domain from the talin rod unfolds to form a complex with the vinculin head.

Fillingham I, Gingras AR, Papagrigoriou E, Patel B, Emsley J, Critchley DR, Roberts GC, Barsukov IL.

Structure. 2005 Jan;13(1):65-74.

5.

The vinculin binding sites of talin and alpha-actinin are sufficient to activate vinculin.

Bois PR, O'Hara BP, Nietlispach D, Kirkpatrick J, Izard T.

J Biol Chem. 2006 Mar 17;281(11):7228-36. Epub 2006 Jan 9.

6.

Structural and dynamic characterization of a vinculin binding site in the talin rod.

Gingras AR, Vogel KP, Steinhoff HJ, Ziegler WH, Patel B, Emsley J, Critchley DR, Roberts GC, Barsukov IL.

Biochemistry. 2006 Feb 14;45(6):1805-17.

PMID:
16460027
7.

Crystal structure of vinculin in complex with vinculin binding site 50 (VBS50), the integrin binding site 2 (IBS2) of talin.

Yogesha SD, Rangarajan ES, Vonrhein C, Bricogne G, Izard T.

Protein Sci. 2012 Apr;21(4):583-8. doi: 10.1002/pro.2041. Epub 2012 Feb 28.

8.

Integrin connections to the cytoskeleton through talin and vinculin.

Ziegler WH, Gingras AR, Critchley DR, Emsley J.

Biochem Soc Trans. 2008 Apr;36(Pt 2):235-9. doi: 10.1042/BST0360235. Review.

PMID:
18363566
9.

Vinculin activation is necessary for complete talin binding.

Golji J, Lam J, Mofrad MR.

Biophys J. 2011 Jan 19;100(2):332-40. doi: 10.1016/j.bpj.2010.11.024.

10.

Mapping and consensus sequence identification for multiple vinculin binding sites within the talin rod.

Gingras AR, Ziegler WH, Frank R, Barsukov IL, Roberts GC, Critchley DR, Emsley J.

J Biol Chem. 2005 Nov 4;280(44):37217-24. Epub 2005 Aug 30.

11.

Intermolecular versus intramolecular interactions of the vinculin binding site 33 of talin.

Yogesha SD, Sharff A, Bricogne G, Izard T.

Protein Sci. 2011 Aug;20(8):1471-6. doi: 10.1002/pro.671.

12.

The activity of the vinculin binding sites in talin is influenced by the stability of the helical bundles that make up the talin rod.

Patel B, Gingras AR, Bobkov AA, Fujimoto LM, Zhang M, Liddington RC, Mazzeo D, Emsley J, Roberts GC, Barsukov IL, Critchley DR.

J Biol Chem. 2006 Mar 17;281(11):7458-67. Epub 2006 Jan 9.

13.

Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion.

Critchley DR.

Biochem Soc Trans. 2004 Nov;32(Pt 5):831-6. Review.

PMID:
15494027
14.

Vinculin activation by talin through helical bundle conversion.

Izard T, Evans G, Borgon RA, Rush CL, Bricogne G, Bois PR.

Nature. 2004 Jan 8;427(6970):171-5. Epub 2003 Dec 31.

PMID:
14702644
15.

Rhombohedral crystals of the human vinculin head domain in complex with a vinculin-binding site of talin.

Rush CL, Izard T.

Acta Crystallogr D Biol Crystallogr. 2004 May;60(Pt 5):945-7. Epub 2004 Apr 21.

PMID:
15103147
16.

Talin contains three similar vinculin-binding sites predicted to form an amphipathic helix.

Bass MD, Smith BJ, Prigent SA, Critchley DR.

Biochem J. 1999 Jul 15;341 ( Pt 2):257-63.

17.

Two distinct head-tail interfaces cooperate to suppress activation of vinculin by talin.

Cohen DM, Chen H, Johnson RP, Choudhury B, Craig SW.

J Biol Chem. 2005 Apr 29;280(17):17109-17. Epub 2005 Feb 22.

18.

Force-induced activation of talin and its possible role in focal adhesion mechanotransduction.

Lee SE, Kamm RD, Mofrad MR.

J Biomech. 2007;40(9):2096-106.

PMID:
17544431
19.

Structural basis for amplifying vinculin activation by talin.

Izard T, Vonrhein C.

J Biol Chem. 2004 Jun 25;279(26):27667-78. Epub 2004 Apr 7.

20.

Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle.

Papagrigoriou E, Gingras AR, Barsukov IL, Bate N, Fillingham IJ, Patel B, Frank R, Ziegler WH, Roberts GC, Critchley DR, Emsley J.

EMBO J. 2004 Aug 4;23(15):2942-51. Epub 2004 Jul 22.

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