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Items: 1 to 20 of 117

1.

Phosphorylation of beta-amyloid precursor protein (APP) cytoplasmic tail facilitates amyloidogenic processing during apoptosis.

Sodhi CP, Perez RG, Gottardi-Littell NR.

Brain Res. 2008 Mar 10;1198:204-12. doi: 10.1016/j.brainres.2008.01.031. Epub 2008 Jan 26.

PMID:
18275940
2.

The endocytotic pathway is required for increased A beta 42 secretion during apoptosis.

Sodhi CP, Rampalli S, Perez RG, Koo EH, Quinn B, Gottardi-Littell NR.

Brain Res Mol Brain Res. 2004 Sep 28;128(2):201-11.

PMID:
15363895
3.

The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production.

Pastorino L, Sun A, Lu PJ, Zhou XZ, Balastik M, Finn G, Wulf G, Lim J, Li SH, Li X, Xia W, Nicholson LK, Lu KP.

Nature. 2006 Mar 23;440(7083):528-34. Erratum in: Nature. 2007 Mar 15;446(7133):342.

PMID:
16554819
4.

Phosphorylation of amyloid precursor protein (APP) at Thr668 regulates the nuclear translocation of the APP intracellular domain and induces neurodegeneration.

Chang KA, Kim HS, Ha TY, Ha JW, Shin KY, Jeong YH, Lee JP, Park CH, Kim S, Baik TK, Suh YH.

Mol Cell Biol. 2006 Jun;26(11):4327-38.

5.

Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism.

Vingtdeux V, Hamdane M, Gompel M, Bégard S, Drobecq H, Ghestem A, Grosjean ME, Kostanjevecki V, Grognet P, Vanmechelen E, Buée L, Delacourte A, Sergeant N.

Neurobiol Dis. 2005 Nov;20(2):625-37. Epub 2005 Jun 3.

PMID:
15936948
6.

Physiological mouse brain Abeta levels are not related to the phosphorylation state of threonine-668 of Alzheimer's APP.

Sano Y, Nakaya T, Pedrini S, Takeda S, Iijima-Ando K, Iijima K, Mathews PM, Itohara S, Gandy S, Suzuki T.

PLoS One. 2006 Dec 20;1:e51.

7.

The role of cytosolic phospholipase A2 α in amyloid precursor protein induction by amyloid beta1-42 : implication for neurodegeneration.

Sagy-Bross C, Kasianov K, Solomonov Y, Braiman A, Friedman A, Hadad N, Levy R.

J Neurochem. 2015 Mar;132(5):559-71. doi: 10.1111/jnc.13012. Epub 2015 Feb 3.

8.

JNK regulates APP cleavage and degradation in a model of Alzheimer's disease.

Colombo A, Bastone A, Ploia C, Sclip A, Salmona M, Forloni G, Borsello T.

Neurobiol Dis. 2009 Mar;33(3):518-25. doi: 10.1016/j.nbd.2008.12.014. Epub 2009 Jan 8.

PMID:
19166938
9.

APP processing is regulated by cytoplasmic phosphorylation.

Lee MS, Kao SC, Lemere CA, Xia W, Tseng HC, Zhou Y, Neve R, Ahlijanian MK, Tsai LH.

J Cell Biol. 2003 Oct 13;163(1):83-95.

10.

The cytoplasmic domain of Alzheimer's amyloid precursor protein is phosphorylated at Thr654, Ser655, and Thr668 in adult rat brain and cultured cells.

Oishi M, Nairn AC, Czernik AJ, Lim GS, Isohara T, Gandy SE, Greengard P, Suzuki T.

Mol Med. 1997 Feb;3(2):111-23.

11.

Alzheimer's disease.

De-Paula VJ, Radanovic M, Diniz BS, Forlenza OV.

Subcell Biochem. 2012;65:329-52. doi: 10.1007/978-94-007-5416-4_14. Review.

PMID:
23225010
12.

Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.

Xia W, Zhang J, Ostaszewski BL, Kimberly WT, Seubert P, Koo EH, Shen J, Selkoe DJ.

Biochemistry. 1998 Nov 24;37(47):16465-71.

PMID:
9843412
13.
14.

Amyloid-beta precursor protein mediates neuronal toxicity of amyloid beta through Go protein activation.

Sola Vigo F, Kedikian G, Heredia L, Heredia F, Añel AD, Rosa AL, Lorenzo A.

Neurobiol Aging. 2009 Sep;30(9):1379-92. doi: 10.1016/j.neurobiolaging.2007.11.017. Epub 2008 Jan 10.

PMID:
18187234
15.

Variations in the effects on synthesis of amyloid beta protein in modulated autophagic conditions.

Makioka K, Yamazaki T, Kakuda S, Okamoto K.

Neurol Res. 2009 Nov;31(9):959-68. doi: 10.1179/174313209X395463. Epub 2009 Feb 11.

PMID:
19215663
16.
17.

Hypoxic stress, brain vascular system, and β-amyloid: a primary cell culture study.

Muche A, Bürger S, Arendt T, Schliebs R.

Nutr Neurosci. 2015 Jan;18(1):1-11. doi: 10.1179/1476830513Z.000000000112. Epub 2013 Nov 20.

PMID:
24257464
18.

Regulation of amyloid precursor protein catabolism involves the mitogen-activated protein kinase signal transduction pathway.

Mills J, Laurent Charest D, Lam F, Beyreuther K, Ida N, Pelech SL, Reiner PB.

J Neurosci. 1997 Dec 15;17(24):9415-22.

19.
20.

Atorvastatin-induced activation of Alzheimer's alpha secretase is resistant to standard inhibitors of protein phosphorylation-regulated ectodomain shedding.

Parvathy S, Ehrlich M, Pedrini S, Diaz N, Refolo L, Buxbaum JD, Bogush A, Petanceska S, Gandy S.

J Neurochem. 2004 Aug;90(4):1005-10.

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