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Items: 1 to 20 of 115

1.

Kinetics and thermodynamics of the interchange of the morpheein forms of human porphobilinogen synthase.

Selwood T, Tang L, Lawrence SH, Anokhina Y, Jaffe EK.

Biochemistry. 2008 Mar 11;47(10):3245-57. doi: 10.1021/bi702113z.

PMID:
18271513
2.

Single amino acid mutations alter the distribution of human porphobilinogen synthase quaternary structure isoforms (morpheeins).

Tang L, Breinig S, Stith L, Mischel A, Tannir J, Kokona B, Fairman R, Jaffe EK.

J Biol Chem. 2006 Mar 10;281(10):6682-90.

3.

Control of tetrapyrrole biosynthesis by alternate quaternary forms of porphobilinogen synthase.

Breinig S, Kervinen J, Stith L, Wasson AS, Fairman R, Wlodawer A, Zdanov A, Jaffe EK.

Nat Struct Biol. 2003 Sep;10(9):757-63.

PMID:
12897770
4.

Substrate-induced interconversion of protein quaternary structure isoforms.

Tang L, Stith L, Jaffe EK.

J Biol Chem. 2005 Apr 22;280(16):15786-93.

5.

Mechanistic implications of mutations to the active site lysine of porphobilinogen synthase.

Mitchell LW, Volin M, Martins J, Jaffe EK.

J Biol Chem. 2001 Jan 12;276(2):1538-44.

6.

Probing the oligomeric assemblies of pea porphobilinogen synthase by analytical ultracentrifugation.

Kokona B, Rigotti DJ, Wasson AS, Lawrence SH, Jaffe EK, Fairman R.

Biochemistry. 2008 Oct 7;47(40):10649-56. doi: 10.1021/bi801128d.

7.

The Remarkable Character of Porphobilinogen Synthase.

Jaffe EK.

Acc Chem Res. 2016 Nov 15;49(11):2509-2517.

PMID:
27783504
8.

ALAD porphyria is a conformational disease.

Jaffe EK, Stith L.

Am J Hum Genet. 2007 Feb;80(2):329-37.

9.

Morpheeins--a new structural paradigm for allosteric regulation.

Jaffe EK.

Trends Biochem Sci. 2005 Sep;30(9):490-7. Review.

PMID:
16023348
10.

Pseudomonas aeruginosa contains a novel type V porphobilinogen synthase with no required catalytic metal ions.

Frankenberg N, Jahn D, Jaffe EK.

Biochemistry. 1999 Oct 19;38(42):13976-82.

PMID:
10529244
11.

Porphobilinogen synthase from Escherichia coli is a Zn(II) metalloenzyme stimulated by Mg(II).

Mitchell LW, Jaffe EK.

Arch Biochem Biophys. 1993 Jan;300(1):169-77.

PMID:
8424649
12.

Redox and metal-regulated oligomeric state for human porphobilinogen synthase activation.

Sawada N, Nagahara N, Arisaka F, Mitsuoka K, Minami M.

Amino Acids. 2011 Jun;41(1):173-80. doi: 10.1007/s00726-010-0570-y.

PMID:
20354739
13.

Bradyrhizobium japonicum porphobilinogen synthase uses two Mg(II) and monovalent cations.

Petrovich RM, Litwin S, Jaffe EK.

J Biol Chem. 1996 Apr 12;271(15):8692-9.

14.

Allosteric inhibition of human porphobilinogen synthase.

Lawrence SH, Ramirez UD, Selwood T, Stith L, Jaffe EK.

J Biol Chem. 2009 Dec 18;284(51):35807-17. doi: 10.1074/jbc.M109.026294.

15.

5-Chlorolevulinate modification of porphobilinogen synthase identifies a potential role for the catalytic zinc.

Jaffe EK, Abrams WR, Kaempfen HX, Harris KA Jr.

Biochemistry. 1992 Feb 25;31(7):2113-23.

PMID:
1346974
16.

Crystal structure of Toxoplasma gondii porphobilinogen synthase: insights on octameric structure and porphobilinogen formation.

Jaffe EK, Shanmugam D, Gardberg A, Dieterich S, Sankaran B, Stewart LJ, Myler PJ, Roos DS.

J Biol Chem. 2011 Apr 29;286(17):15298-307. doi: 10.1074/jbc.M111.226225.

17.

Investigations on the metal switch region of human porphobilinogen synthase.

Jaffe EK.

J Biol Inorg Chem. 2003 Jan;8(1-2):176-84.

PMID:
12459913
18.

Tracking the evolution of porphobilinogen synthase metal dependence in vitro.

Frère F, Reents H, Schubert WD, Heinz DW, Jahn D.

J Mol Biol. 2005 Feb 4;345(5):1059-70.

PMID:
15644204
19.

The molecular mechanism of lead inhibition of human porphobilinogen synthase.

Jaffe EK, Martins J, Li J, Kervinen J, Dunbrack RL Jr.

J Biol Chem. 2001 Jan 12;276(2):1531-7.

20.

Porphobilinogen synthase from pea: expression from an artificial gene, kinetic characterization, and novel implications for subunit interactions.

Kervinen J, Dunbrack RL Jr, Litwin S, Martins J, Scarrow RC, Volin M, Yeung AT, Yoon E, Jaffe EK.

Biochemistry. 2000 Aug 1;39(30):9018-29.

PMID:
10913315
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