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Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization.

Cassidy-Stone A, Chipuk JE, Ingerman E, Song C, Yoo C, Kuwana T, Kurth MJ, Shaw JT, Hinshaw JE, Green DR, Nunnari J.

Dev Cell. 2008 Feb;14(2):193-204. doi: 10.1016/j.devcel.2007.11.019.


Drp1 is dispensable for apoptotic cytochrome c release in primed MCF10A and fibroblast cells but affects Bcl-2 antagonist-induced respiratory changes.

Clerc P, Ge SX, Hwang H, Waddell J, Roelofs BA, Karbowski M, Sesaki H, Polster BM.

Br J Pharmacol. 2014 Apr;171(8):1988-99. doi: 10.1111/bph.12515.


The combination of thioxodihydroquinazolinones and platinum drugs reverses platinum resistance in tumor cells by inducing mitochondrial apoptosis independent of Bax and Bak.

Qian W, Salamoun J, Wang J, Roginskaya V, Van Houten B, Wipf P.

Bioorg Med Chem Lett. 2015 Feb 15;25(4):856-63. doi: 10.1016/j.bmcl.2014.12.072. Epub 2014 Dec 30.


Amelioration of ischemic mitochondrial injury and Bax-dependent outer membrane permeabilization by Mdivi-1.

Zhao YX, Cui M, Chen SF, Dong Q, Liu XY.

CNS Neurosci Ther. 2014 Jun;20(6):528-38. doi: 10.1111/cns.12266. Epub 2014 Apr 8.


VDAC2 is required for truncated BID-induced mitochondrial apoptosis by recruiting BAK to the mitochondria.

Roy SS, Ehrlich AM, Craigen WJ, Hajnóczky G.

EMBO Rep. 2009 Dec;10(12):1341-7. doi: 10.1038/embor.2009.219. Epub 2009 Oct 9.


The multidomain proapoptotic molecules Bax and Bak are directly activated by heat.

Pagliari LJ, Kuwana T, Bonzon C, Newmeyer DD, Tu S, Beere HM, Green DR.

Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):17975-80. Epub 2005 Dec 5.


The Putative Drp1 Inhibitor mdivi-1 Is a Reversible Mitochondrial Complex I Inhibitor that Modulates Reactive Oxygen Species.

Bordt EA, Clerc P, Roelofs BA, Saladino AJ, Tretter L, Adam-Vizi V, Cherok E, Khalil A, Yadava N, Ge SX, Francis TC, Kennedy NW, Picton LK, Kumar T, Uppuluri S, Miller AM, Itoh K, Karbowski M, Sesaki H, Hill RB, Polster BM.

Dev Cell. 2017 Mar 27;40(6):583-594.e6. doi: 10.1016/j.devcel.2017.02.020.


Bax-mediated mitochondrial outer membrane permeabilization (MOMP), distinct from the mitochondrial permeability transition, is a key mechanism in diclofenac-induced hepatocyte injury: Multiple protective roles of cyclosporin A.

Siu WP, Pun PB, Latchoumycandane C, Boelsterli UA.

Toxicol Appl Pharmacol. 2008 Mar 15;227(3):451-61. doi: 10.1016/j.taap.2007.11.030. Epub 2007 Dec 14.


Apoptosis-associated mitochondrial outer membrane permeabilization assays.

Arnoult D.

Methods. 2008 Mar;44(3):229-34. doi: 10.1016/j.ymeth.2007.11.003. Review.


Inhibiting the mitochondrial fission machinery does not prevent Bax/Bak-dependent apoptosis.

Parone PA, James DI, Da Cruz S, Mattenberger Y, Donzé O, Barja F, Martinou JC.

Mol Cell Biol. 2006 Oct;26(20):7397-408.


Bax/Bak promote sumoylation of DRP1 and its stable association with mitochondria during apoptotic cell death.

Wasiak S, Zunino R, McBride HM.

J Cell Biol. 2007 May 7;177(3):439-50. Epub 2007 Apr 30.


Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis.

Jiang X, Jiang H, Shen Z, Wang X.

Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14782-7. doi: 10.1073/pnas.1417253111. Epub 2014 Oct 1.


BAK/BAX activation and cytochrome c release assays using isolated mitochondria.

Renault TT, Floros KV, Chipuk JE.

Methods. 2013 Jun 1;61(2):146-55. doi: 10.1016/j.ymeth.2013.03.030. Epub 2013 Apr 6.


Inhibition of mitochondrial fission attenuates Aβ-induced microglia apoptosis.

Xie N, Wang C, Lian Y, Wu C, Zhang H, Zhang Q.

Neuroscience. 2014 Jan 3;256:36-42. doi: 10.1016/j.neuroscience.2013.10.011. Epub 2013 Oct 18.


Death upon a kiss: mitochondrial outer membrane composition and organelle communication govern sensitivity to BAK/BAX-dependent apoptosis.

Renault TT, Chipuk JE.

Chem Biol. 2014 Jan 16;21(1):114-23. doi: 10.1016/j.chembiol.2013.10.009. Epub 2013 Nov 21. Review.


A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis.

Tanaka A, Youle RJ.

Mol Cell. 2008 Feb 29;29(4):409-10. doi: 10.1016/j.molcel.2008.02.005.


Mdivi-1 prevents apoptosis induced by ischemia-reperfusion injury in primary hippocampal cells via inhibition of reactive oxygen species-activated mitochondrial pathway.

Wang J, Wang P, Li S, Wang S, Li Y, Liang N, Wang M.

J Stroke Cerebrovasc Dis. 2014 Jul;23(6):1491-9. doi: 10.1016/j.jstrokecerebrovasdis.2013.12.021. Epub 2014 Apr 26.


Mitochondrial ceramide-rich macrodomains functionalize Bax upon irradiation.

Lee H, Rotolo JA, Mesicek J, Penate-Medina T, Rimner A, Liao WC, Yin X, Ragupathi G, Ehleiter D, Gulbins E, Zhai D, Reed JC, Haimovitz-Friedman A, Fuks Z, Kolesnick R.

PLoS One. 2011;6(6):e19783. doi: 10.1371/journal.pone.0019783. Epub 2011 Jun 13. Erratum in: PLoS One. 2015;10(12):e0146210.


Bax is essential for Drp1-mediated mitochondrial fission but not for mitochondrial outer membrane permeabilization caused by photodynamic therapy.

Wu S, Zhou F, Zhang Z, Xing D.

J Cell Physiol. 2011 Feb;226(2):530-41. doi: 10.1002/jcp.22362.


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