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Items: 1 to 20 of 188

1.

Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia.

Uda M, Galanello R, Sanna S, Lettre G, Sankaran VG, Chen W, Usala G, Busonero F, Maschio A, Albai G, Piras MG, Sestu N, Lai S, Dei M, Mulas A, Crisponi L, Naitza S, Asunis I, Deiana M, Nagaraja R, Perseu L, Satta S, Cipollina MD, Sollaino C, Moi P, Hirschhorn JN, Orkin SH, Abecasis GR, Schlessinger D, Cao A.

Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1620-5. doi: 10.1073/pnas.0711566105. Epub 2008 Feb 1.

2.

Polymorphic variations influencing fetal hemoglobin levels: association study in beta-thalassemia carriers and in normal individuals of Portuguese origin.

Pereira C, Relvas L, Bento C, Abade A, Ribeiro ML, Manco L.

Blood Cells Mol Dis. 2015 Apr;54(4):315-20. doi: 10.1016/j.bcmd.2015.02.001. Epub 2015 Feb 21.

PMID:
25842369
3.

[Correlation between hemoglobin F levels and single nucleotide polymorphism at BCL11A gene rs11886868 locus in β-thalassemia patients].

Chen QR, Sun SC, Peng YS, Wang Q, Mo BM.

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2012 Jun;20(3):650-3. Chinese.

PMID:
22739175
4.

BCL11A is a major HbF quantitative trait locus in three different populations with beta-hemoglobinopathies.

Sedgewick AE, Timofeev N, Sebastiani P, So JC, Ma ES, Chan LC, Fucharoen G, Fucharoen S, Barbosa CG, Vardarajan BN, Farrer LA, Baldwin CT, Steinberg MH, Chui DH.

Blood Cells Mol Dis. 2008 Nov-Dec;41(3):255-8. doi: 10.1016/j.bcmd.2008.06.007. Epub 2008 Aug 8.

5.

DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease.

Lettre G, Sankaran VG, Bezerra MA, Araújo AS, Uda M, Sanna S, Cao A, Schlessinger D, Costa FF, Hirschhorn JN, Orkin SH.

Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11869-74. doi: 10.1073/pnas.0804799105. Epub 2008 Jul 30.

6.

rs11886868 and rs4671393 of BCL11A associated with HbF level variation and modulate clinical events among sickle cell anemia patients.

Chaouch L, Moumni I, Ouragini H, Darragi I, Kalai M, Chaouachi D, Boudrigua I, Hafsia R, Abbes S.

Hematology. 2016 Aug;21(7):425-9. doi: 10.1080/10245332.2015.1107275. Epub 2016 Jan 22.

PMID:
27077760
7.

Modifying effect of XmnI, BCL11A, and HBS1L-MYB on clinical appearances: A study on β-thalassemia and hemoglobin E/β-thalassemia patients in Indonesia.

Rujito L, Basalamah M, Siswandari W, Setyono J, Wulandari G, Mulatsih S, Sofro AS, Sadewa AH, Sutaryo S.

Hematol Oncol Stem Cell Ther. 2016 Jun;9(2):55-63. doi: 10.1016/j.hemonc.2016.02.003. Epub 2016 Mar 17.

8.

Transcriptional silencing of fetal hemoglobin by BCL11A.

Sankaran VG, Xu J, Orkin SH.

Ann N Y Acad Sci. 2010 Aug;1202:64-8. doi: 10.1111/j.1749-6632.2010.05574.x.

PMID:
20712774
9.

The influence of the BCL11A polymorphism on the phenotype of patients with beta thalassemia could be affected by the beta globin locus control region and/or the Xmn1-HBG2 genotypic background.

Neishabury M, Zamani F, Keyhani E, Azarkeivan A, Abedini SS, Eslami MS, Kakroodi ST, Vesiehsari MJ, Najmabadi H.

Blood Cells Mol Dis. 2013 Aug;51(2):80-4. doi: 10.1016/j.bcmd.2013.02.007. Epub 2013 Mar 28.

PMID:
23541515
10.

Amelioration of Sardinian beta0 thalassemia by genetic modifiers.

Galanello R, Sanna S, Perseu L, Sollaino MC, Satta S, Lai ME, Barella S, Uda M, Usala G, Abecasis GR, Cao A.

Blood. 2009 Oct 29;114(18):3935-7. doi: 10.1182/blood-2009-04-217901. Epub 2009 Aug 20.

11.

The XmnI (G)gamma polymorphism influences hemoglobin F synthesis contrary to BCL11A and HBS1L-MYB SNPs in a cohort of 57 beta-thalassemia intermedia patients.

Nguyen TK, Joly P, Bardel C, Moulsma M, Bonello-Palot N, Francina A.

Blood Cells Mol Dis. 2010 Aug 15;45(2):124-7. doi: 10.1016/j.bcmd.2010.04.002. Epub 2010 May 15.

PMID:
20472475
12.

Hemoglobin switching's surprise: the versatile transcription factor BCL11A is a master repressor of fetal hemoglobin.

Bauer DE, Orkin SH.

Curr Opin Genet Dev. 2015 Aug;33:62-70. doi: 10.1016/j.gde.2015.08.001. Epub 2015 Sep 14. Review.

13.

Association of variants at BCL11A and HBS1L-MYB with hemoglobin F and hospitalization rates among sickle cell patients in Cameroon.

Wonkam A, Ngo Bitoungui VJ, Vorster AA, Ramesar R, Cooper RS, Tayo B, Lettre G, Ngogang J.

PLoS One. 2014 Mar 25;9(3):e92506. doi: 10.1371/journal.pone.0092506. eCollection 2014.

14.

Annotated definition of BCL11A and HMIP-2 haplotypes through the analysis of sicilian β-thalassemia patients with high levels of fetal hemoglobin.

Buccheri MA, Spina S, Ruberto C, Lombardo T, Labie D, Ragusa AA.

Hemoglobin. 2013;37(5):423-34. doi: 10.3109/03630269.2013.800823. Epub 2013 Jun 19.

PMID:
23777413
15.

Influences of genetic variation on fetal hemoglobin.

He Y, Lin W, Luo J.

Pediatr Hematol Oncol. 2011 Nov;28(8):708-17. doi: 10.3109/08880018.2011.616573.

PMID:
22023465
16.

2p15-p16.1 microdeletions encompassing and proximal to BCL11A are associated with elevated HbF in addition to neurologic impairment.

Funnell AP, Prontera P, Ottaviani V, Piccione M, Giambona A, Maggio A, Ciaffoni F, Stehling-Sun S, Marra M, Masiello F, Varricchio L, Stamatoyannopoulos JA, Migliaccio AR, Papayannopoulou T.

Blood. 2015 Jul 2;126(1):89-93. doi: 10.1182/blood-2015-04-638528. Epub 2015 May 27.

17.

Association of Xmn1 -158 γG variant with severity and HbF levels in β-thalassemia major and sickle cell anaemia.

Dadheech S, Jain S, Madhulatha D, Sharma V, Joseph J, Jyothy A, Munshi A.

Mol Biol Rep. 2014 May;41(5):3331-7. doi: 10.1007/s11033-014-3195-5. Epub 2014 Feb 2.

PMID:
24488321
18.

Fetal hemoglobin regulation in β-thalassemia: heterogeneity, modifiers and therapeutic approaches.

Sripichai O, Fucharoen S.

Expert Rev Hematol. 2016 Dec;9(12):1129-1137. Epub 2016 Nov 16. Review.

PMID:
27801605
19.

Association of BCL11A genetic variant (rs11886868) with severity in β-thalassaemia major & sickle cell anaemia.

Dadheech S, Madhulatha D, Jainc S, Joseph J, Jyothy A, Munshi A.

Indian J Med Res. 2016 Apr;143(4):449-54. doi: 10.4103/0971-5916.184285.

20.

Genetic variant in the BCL11A (rs1427407), but not HBS1-MYB (rs6934903) loci associate with fetal hemoglobin levels in Indian sickle cell disease patients.

Bhanushali AA, Patra PK, Nair D, Verma H, Das BR.

Blood Cells Mol Dis. 2015 Jan;54(1):4-8. doi: 10.1016/j.bcmd.2014.10.003. Epub 2014 Nov 6.

PMID:
25457385

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