Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 123


Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APC(Cdh1) in G1 phase.

Rodier G, Coulombe P, Tanguay PL, Boutonnet C, Meloche S.

EMBO J. 2008 Feb 20;27(4):679-91. doi: 10.1038/emboj.2008.6. Epub 2008 Jan 31.


Phosphorylation of Ser72 is dispensable for Skp2 assembly into an active SCF ubiquitin ligase and its subcellular localization.

Bashir T, Pagan JK, Busino L, Pagano M.

Cell Cycle. 2010 Mar 1;9(5):971-4. Epub 2010 Mar 9.


Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase.

Bashir T, Dorrello NV, Amador V, Guardavaccaro D, Pagano M.

Nature. 2004 Mar 11;428(6979):190-3.


Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex.

Wei W, Ayad NG, Wan Y, Zhang GJ, Kirschner MW, Kaelin WG Jr.

Nature. 2004 Mar 11;428(6979):194-8.


Cell adhesion induces p27Kip1-associated cell-cycle arrest through down-regulation of the SCFSkp2 ubiquitin ligase pathway in mantle-cell and other non-Hodgkin B-cell lymphomas.

Lwin T, Hazlehurst LA, Dessureault S, Lai R, Bai W, Sotomayor E, Moscinski LC, Dalton WS, Tao J.

Blood. 2007 Sep 1;110(5):1631-8. Epub 2007 May 14.


Phosphorylation of Ser72 does not regulate the ubiquitin ligase activity and subcellular localization of Skp2.

Boutonnet C, Tanguay PL, Julien C, Rodier G, Coulombe P, Meloche S.

Cell Cycle. 2010 Mar 1;9(5):975-9. Epub 2010 Mar 9.


Early mitotic inhibitor-1, an anaphase-promoting complex/cyclosome inhibitor, can control tumor cell proliferation in hepatocellular carcinoma: correlation with Skp2 stability and degradation of p27(Kip1).

Zhao Y, Tang Q, Ni R, Huang X, Wang Y, Lu C, Shen A, Wang Y, Li C, Yuan Q, Chen H, Cheng C, He S.

Hum Pathol. 2013 Mar;44(3):365-73. doi: 10.1016/j.humpath.2012.03.030. Epub 2012 Sep 17.


Don't skip the G1 phase: how APC/CCdh1 keeps SCFSKP2 in check.

Bashir T, Pagano M.

Cell Cycle. 2004 Jul;3(7):850-2. Epub 2004 Jul 14. Review.


Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit.

Binné UK, Classon MK, Dick FA, Wei W, Rape M, Kaelin WG Jr, Näär AM, Dyson NJ.

Nat Cell Biol. 2007 Feb;9(2):225-32. Epub 2006 Dec 24. Erratum in: Nat Cell Biol. 2007 Mar;9(3):353.


Regulation of Skp2-p27 axis by the Cdh1/anaphase-promoting complex pathway in colorectal tumorigenesis.

Fujita T, Liu W, Doihara H, Wan Y.

Am J Pathol. 2008 Jul;173(1):217-28. doi: 10.2353/ajpath.2008.070957. Epub 2008 Jun 5.


Cdh1-anaphase-promoting complex targets Skp2 for destruction in transforming growth factor beta-induced growth inhibition.

Liu W, Wu G, Li W, Lobur D, Wan Y.

Mol Cell Biol. 2007 Apr;27(8):2967-79. Epub 2007 Feb 5.


Regulation of Skp2 levels by the Pim-1 protein kinase.

Cen B, Mahajan S, Zemskova M, Beharry Z, Lin YW, Cramer SD, Lilly MB, Kraft AS.

J Biol Chem. 2010 Sep 17;285(38):29128-37. doi: 10.1074/jbc.M110.137240. Epub 2010 Jul 27.


TGF-β activates APC through Cdh1 binding for Cks1 and Skp2 proteasomal destruction stabilizing p27kip1 for normal endometrial growth.

Pavlides SC, Lecanda J, Daubriac J, Pandya UM, Gama P, Blank S, Mittal K, Shukla P, Gold LI.

Cell Cycle. 2016;15(7):931-47. doi: 10.1080/15384101.2016.1150393.


Skp2-mediated p27(Kip1) degradation during S/G2 phase progression of adipocyte hyperplasia.

Auld CA, Fernandes KM, Morrison RF.

J Cell Physiol. 2007 Apr;211(1):101-11.


Estrogen and progesterone regulate p27kip1 levels via the ubiquitin-proteasome system: pathogenic and therapeutic implications for endometrial cancer.

Huang KT, Pavlides SC, Lecanda J, Blank SV, Mittal KR, Gold LI.

PLoS One. 2012;7(9):e46072. doi: 10.1371/journal.pone.0046072. Epub 2012 Sep 27.


Uncovering the role of APC-Cdh1 in generating the dynamics of S-phase onset.

Yuan X, Srividhya J, De Luca T, Lee JH, Pomerening JR.

Mol Biol Cell. 2014 Feb;25(4):441-56. doi: 10.1091/mbc.E13-08-0480. Epub 2013 Dec 19.


The anaphase promoting complex induces substrate degradation during neuronal differentiation.

Harmey D, Smith A, Simanski S, Moussa CZ, Ayad NG.

J Biol Chem. 2009 Feb 13;284(7):4317-23. doi: 10.1074/jbc.M804944200. Epub 2008 Dec 1.


SKP2 and CKS1 promote degradation of cell cycle regulators and are associated with hepatocellular carcinoma prognosis.

Calvisi DF, Ladu S, Pinna F, Frau M, Tomasi ML, Sini M, Simile MM, Bonelli P, Muroni MR, Seddaiu MA, Lim DS, Feo F, Pascale RM.

Gastroenterology. 2009 Nov;137(5):1816-26.e1-10. doi: 10.1053/j.gastro.2009.08.005. Epub 2009 Aug 15.


Nuclear translocation of Skp2 facilitates its destruction in response to TGFβ signaling.

Hu D, Liu W, Wu G, Wan Y.

Cell Cycle. 2011 Jan 15;10(2):285-92. Epub 2011 Jan 15.

Supplemental Content

Support Center